Details of the Drug Combinations

General Information of This Drug (ID: DM2M3ZA)

Drug Name

Glycopyrrolate DM2M3ZA

Synonyms

GLYCOPYRROLATE; 596-51-0; Glycopyrrolate bromide; Robinul; Gastrodyn; Tarodyl; Nodapton; Tarodyn; Asecryl; Copyrrolate; Cuvposa; Glycopyrronii bromidum; AHR-504; ROBINUL FORTE; Robinal; Robanul; Bromuro de glicopirronio; Bromure de glycopyrronium; NVA-237; AHR 504; Glycopyrronii bromidum [INN-Latin]; EINECS 209-887-0; Bromure de glycopyrronium [INN-French]; Bromuro de glicopirronio [INN-Spanish]; 3-Hydroxy-1,1-dimethylpyrrolidinium bromide

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]
Chronic obstructive pulmonary disease	CA22	Approved	[2]
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Therapeutic Class

Anticholinergic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Glycopyrrolate + MCD-386	DCAZGHB	MCD-386	Alzheimer disease (Cell Line: .)	[3]
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11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Glycopyrrolate + Indacaterol	DCI04QU	Indacaterol	Chronic Obstructive Pulmonary Disease: COPD	[4]
Glycopyrrolate + Indacaterol	DCJJHCR	Indacaterol	Chronic Obstructive Pulmonary Disease	[5]
Glycopyrrolate + Neostigmine	DCJMR2I	Neostigmine	Surgical Procedures, Elective	[6]
Glycopyrrolate + Salbutamol	DCWDUM9	Salbutamol	Chronic Obstructive Pulmonary Disease	[7]
Glycopyrrolate + Neostigmine	DCO1DM0	Neostigmine	Gastrointestinal Dysfunction	[8]
Glycopyrrolate + Neostigmine	DC0I7J9	Neostigmine	Anesthesia, General	[9]
Glycopyrrolate + Neostigmine	DCX75WN	Neostigmine	Anesthesia, General	[9]
Glycopyrrolate + Salbutamol	DCJWETV	Salbutamol	Asthma	[10]
Glycopyrrolate + Desflurane	DCIGES8	Desflurane	Airway Reflexes, Protective	[11]
Glycopyrrolate + Neostigmine	DCOIW4S	Neostigmine	Airway Reflexes, Protective	[11]
Glycopyrrolate + Neostigmine	DCNJP9A	Neostigmine	Surgery	[12]
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⏷ Show the Full List of 11 DrugCom(s)

1 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Glycopyrrolate + Formoterol	DCXWGE9	Formoterol	Cough	[13]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7459).
2	Clinical pipeline report, company report or official report of Novartis.
3	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4	ClinicalTrials.gov (NCT01699685) Swiss studY for the Treatment of COPD Patients With the Free combiNation of indacatERol and GlYcopyrroniumbromide.
5	ClinicalTrials.gov (NCT01529632) Comparison of Safety and Efficacy of the Combination Product QVA149A Against the Concurrent Administration of the Individual Components, QAB149 and NVA237, in Patients With Chronic Obstructive Pulmonary Disease (COPD)
6	ClinicalTrials.gov (NCT01479764) Study of Sugammadex Versus Usual Care on Incidence of Residual Blockade at Post Anesthesia Care Unit Admission (P07981)
7	ClinicalTrials.gov (NCT01120691) Effect of QVA149 Versus NVA237 and Tiotropium on Chronic Obstructive Pulmonary Disorder (COPD) Exacerbations
8	ClinicalTrials.gov (NCT02574611) Use of High Resolution Colonic Manometry in Studying Motility
9	ClinicalTrials.gov (NCT00473694) Comparison of Sugammadex (MK-8616/Org 25969) With Neostigmine Administered at 1-2 Post-tetanic Counts (PTCs) After Administration of Rocuronium or Vecuronium (19.4.302/P05945/MK-8616-025)
10	ClinicalTrials.gov (NCT02127697) Study of Efficacy and Safety of NVA237 in Patients With Poorly Controlled Asthma
11	ClinicalTrials.gov (NCT01199237) Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block
12	ClinicalTrials.gov (NCT03939923) Role of Sugammadex as Reversal Agent in Patients Extubated Immediately After Isolated Coronary Artery Bypass Grafting Surgery
13	UniProt: the universal protein knowledgebase. Nucleic Acids Res. 2017 Jan 4;45(D1):D158-D169. (ID: O95477)