Details of the Drug Combinations

General Information of This Drug (ID: DM2NUH3)

Drug Name
Imipramine   DM2NUH3
Synonyms
Antideprin; Berkomine; Censtim; Censtin; Declomipramine; Dimipressin; Dpid; Dynaprin; Eupramin; Imavate; Imidobenzyle; Imipramin; Imipramina; Imipraminum; Imiprin; Imizin; Imizinum; Impramine; Intalpram; Iramil; Irmin; Janimine; Melipramin; Melipramine; Nelipramin; Norchlorimipramine; Norfranil; Pramine; Prazepine; Promiben;Psychoforin; Surplix; Timolet; Tofranil; Imipramina [Italian]; Tofraniln A; Antideprin (TN); Deprimin (TN); Deprinol (TN); Depsonil (TN); Dyna-zina; Dynaprin (TN); Eupramin (TN); G-22355; Imipramil (TN); Imipramina [INN-Spanish]; Imipramine (INN); Imipramine [INN:BAN]; Imipraminum [INN-Latin]; Irmin (TN); Janimine (TN); Janimine (hydrochloride); Melipramin (TN); SK-Pramine; Surplix (TN); Tofranil(TN); Tofranil (free base); Tofranil (hydrochloride); Tofranil, base; N-(gamma-Dimethylaminopropyl)iminodibenzyl; N-(gamma.-Dimethylaminopropyl)iminodibenzyl; N-(3-Dimethylaminopropyl)-o-iminodibenzyl; 1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine; 10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine; 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine; 2,2'-(3-Dimethylaminopropylimino)bibenzyl; 2,2'-(3-Dimethylaminopropylimino)dibenzyl; 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine; 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine; 5,6-Dihydro-N-(3-(dimethylamino)propyl)-11H-dibenz(b,e)azepine; 5,6-Dihydro-N-[3-(dimethylamino)propyl]-11H-dibenz[b,e]azepine; 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine; 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine; 5H-Dibenz(b,f)azepine,5-[3-(dimethylamino)propyl]-10,11-dihydro-mixed with ethyl alcohol; 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-(9CI)
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Nocturia MF55 Approved [2]
Therapeutic Class
Antidepressants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

64 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Allopurinol + Imipramine DCCE18N Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
AS-1949490 + Imipramine DCFR27V AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bortezomib + Imipramine DCH3HYX Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Imipramine DC2XGBA Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BRL-15572 + Imipramine DCPO895 BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cevimeline + Imipramine DCS92ZS Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorambucil + Imipramine DCNWFYV Chlorambucil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cisatracurium + Imipramine DCD9W1J Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Citalopram + Imipramine DCCZMVQ Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Clopidogrel + Imipramine DCUKINA Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cytarabine + Imipramine DCK3SU7 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diazoxide + Imipramine DC6HVZG Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diethylcarbamazine + Imipramine DCOVRHL Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Emetine + Imipramine DCP7YYV Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Endoxifen + Imipramine DCRZQQI Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Epinephrine + Imipramine DCF04R4 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Eptifibatide + Imipramine DCKJ3FU Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fomepizole + Imipramine DCJZZO7 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imatinib + Imipramine DCHPALV Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Ribavirin-TP DC5ROQM Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Rifampin DC0Q2KE Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Memantine DC1NCVS Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Docetaxel DCQQ1VG Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + LY03004 DCYHDD6 LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Methoxsalen DC5F6AG Methoxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Fluspirilene DCQLMRE Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Arfolitixorin DC2H6WG Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + BIO-300 DCZ7C5U BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Niclosamide DC45JGT Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Pramipexole DCG962O Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Maprotiline DCXPL1Z Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole DCTXQDA 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Leflunomide DCZ269G Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Bumetanide DC912SV Bumetanide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Hyodeoxycholic acid DCSSFEX Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Spironolactone DCXIXBF Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Mefloquine DCCPUCJ Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Sumatriptan DC6O1GN Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Auranofin DCVA9HM Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Imipramine + Nitrosoglutathione DCYWUTT Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isoproterenol + Imipramine DCA8JCV Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
IT-141 + Imipramine DCII0IJ IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Lubiprostone + Imipramine DCF1C4T Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Imipramine DCOLW01 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mebutamate + Imipramine DCXECK5 Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methylene blue + Imipramine DCWVVWC Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metyrosine + Imipramine DCW4PXA Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Imipramine DCV1YQ4 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Naringenin + Imipramine DCY60FH Naringenin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Oxyphenbutazone + Imipramine DC6V8Z2 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pazopanib HCl + Imipramine DCUI5UB Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PFK-158 + Imipramine DCZD8LK PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pyrazinamide + Imipramine DCZ9JBP Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
SCH 727965 + Imipramine DCUQR3J SCH 727965 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sivelestat + Imipramine DC2OL4M Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Terazosin + Imipramine DCO6I3Y Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Teriflunomide + Imipramine DC2J7ZX Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Testosterone cypionate + Imipramine DC9II5O Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tiagabine + Imipramine DCHZ3GW Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triapine + Imipramine DCKNSI1 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trimethobenzamide + Imipramine DCRQAU7 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Vinblastine + Imipramine DC4B1XB Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Vorinostat + Imipramine DCDHQWA Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
WAY-100635 + Imipramine DCXQQSZ WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 64 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Imipramine + Fluoxetine DCEJ70F Fluoxetine Major Depression [5]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 357).
2 Imipramine FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5 ClinicalTrials.gov (NCT00296725) Dichotic Listening as a Predictor of Medication Response in Depression