Details of the Drug Combinations

General Information of This Drug (ID: DM2TO9R)

• Drug Name: Desflurane (DM2TO9R)
• Synonyms: Desflurano; Desfluranum; Suprane; I 653; I653; PC6781E; Desflurane [USAN:INN]; Desflurano [INN-Spanish]; Desfluranum [INN-Latin]; I-653; R-e 236ea1; Suprane (TN); Desflurane (JAN/USP/INN); Difluoromethyl 1,2,2,2-tetrafluoroethyl ether; (+-)-2-Difluoromethyl 1,2,2,2-tetrafluoroethyl ether; 1,1,1,2-tetrafluoro-2-(difluoromethoxy)ethane; 2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane

Indication

Anaesthesia; ICD 11: 9A78.6; Status: Approved [1]

• Therapeutic Class: Anesthetics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

8 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Desflurane + Propofol	DC5WQ65	Propofol	Obesity	[2]
Desflurane + Alfentanil	DCIH3MU	Alfentanil	Cerebral Ischemia	[3]
Desflurane + Sevoflurane	DCTDREJ	Sevoflurane	Postoperative Delirium	[4]
Desflurane + Remifentanil	DCVDVMF	Remifentanil	Cholecystitis	[5]
Desflurane + Propofol	DC5F967	Propofol	Pediatric Acute Respiratory Distress Syndrome	[6]
Desflurane + Remifentanil	DC84HKW	Remifentanil	Anesthesia	[7]
Desflurane + Propofol	DCL1AGO	Propofol	Anesthesia; Bariatric Surgery	[8]
Glycopyrrolate + Desflurane	DCIGES8	Glycopyrrolate	Airway Reflexes, Protective	[9]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7156).
• [2] ClinicalTrials.gov (NCT03756961) Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery
• [3] ClinicalTrials.gov (NCT01436799) Desflurane Versus Propofol in the Sitting Position
• [4] ClinicalTrials.gov (NCT04707794) Incidence of Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery
• [5] ClinicalTrials.gov (NCT01937104) ONSD According to the Position During Laparoscopy
• [6] ClinicalTrials.gov (NCT05783518) Effect of Desflurane on Pediatric Acute Respiratory Distress Syndrome After Living Donor Liver Transplant Recipients
• [7] ClinicalTrials.gov (NCT02379715) Effect-site Concentration of Remifentanil for Smooth Induction With Desflurane
• [8] ClinicalTrials.gov (NCT03099616) Automated Closed Loop Propofol Anaesthesia Versus Desflurane Inhalation Anaesthesia In Bariatric Surgery
• [9] ClinicalTrials.gov (NCT01199237) Impact of Anesthetic Choice (Sevoflurane Versus Desflurane) on Airway Reflex Recovery in the Context of Antagonized Neuromuscular Block