Details of the Drug Combinations

General Information of This Drug (ID: DM2TUCU)

Drug Name
Crotamiton   DM2TUCU
Synonyms
crotamiton; 483-63-6; N-Ethyl-o-crotonotoluidide; Crotamitone; Crotalgin; Eurax; Veteusan; Euraxil; Eurasil; trans-Crotamiton; Crotamitonum; Crotamitex; Crotan; Crotonyl-N-ethyl-o-toluidine; 124236-29-9; Caswell No. 431B; Crotamitonum [INN-Latin]; UNII-2EEH27851Y; o-CROTONOTOLUIDIDE, N-ETHYL-; EINECS 207-596-3; EPA Pesticide Chemical Code 055701; BRN 3275497; (E)-N-Ethyl-N-(o-tolyl)but-2-enamide; N-Ethyl-N-(2-methylphenyl)-2-butenamide; AI3-17732; DNTGGZPQPQTDQF-XBXARRHUSA-N; 2-Butenamide, N-ethyl-N-(2-methylphenyl)-; 2EEH27851Y
Indication
Disease Entry ICD 11 Status REF
Pruritus EC90 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

58 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Auranofin + Crotamiton DC7PQPU Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Crotamiton DCVPQ5G Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Crotamiton DC5LNC1 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Crotamiton DC47MUB Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Sertraline DCPQXM4 Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Triiodothyronine DCTKGFQ Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Dantrolene DCKCI9J Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Diethylcarbamazine DCYJZMT Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Epinephrine DCZ3U1T Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Sivelestat DC6UGOJ Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Triapine DCJ21AH Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + IT-141 DCDEGYC IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Emetine DCL6H0I Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Chlorzoxazone DCCD06B Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Daidzin DCQZKXX Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Armodafinil DCFWYJD Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Clopidogrel DCMTWMR Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Pentamidine DCARPU7 Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Trazodone DC5U3WE Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Trifluoperazine DCSEEEH Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Tiagabine DCHX6M9 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Bortezomib DC4DR7G Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Dopamine DCIQYMH Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Maprotiline DC09Q7E Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Oxyphenbutazone DCG4T57 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Teriflunomide DCZ3FMF Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Acetohexamide DC1WMD1 Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Amantadine DCBOUAE Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Hyodeoxycholic acid DCIY7IA Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Pizotyline DCM8DND Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Cerivastatin DC8ATNT Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Metaxalone DCVAF7S Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Raltegravir DCMSMVV Raltegravir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Etomidate DCHY7VW Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Crotamiton DCV1WDI Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + Crotamiton DCTA8NU Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + Crotamiton DCCMS8H Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxorubicin + Crotamiton DC3ANR3 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fibrates + Crotamiton DC42BXD Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + Crotamiton DC7N639 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Isoproterenol + Crotamiton DC850O5 Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Kanamycin + Crotamiton DCYYKID Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
LY03004 + Crotamiton DCY8PP4 LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + Crotamiton DC8ZZC4 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + Crotamiton DCA487R Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Crotamiton DCA45YB Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Crotamiton DC6ISCF Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pazopanib HCl + Crotamiton DCSZZVZ Pazopanib HCl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + Crotamiton DCAPLCY Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Rifampin + Crotamiton DC7F3SO Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sumatriptan + Crotamiton DCYT9YI Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + Crotamiton DCHQ82J Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Crotamiton DCTMXIG Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolazoline + Crotamiton DCO2Z1P Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Crotamiton DCF6SEY Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tranexamic acid + Crotamiton DCXAKBJ Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + Crotamiton DCB9EA1 Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Crotamiton DCTSVN0 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.