Details of the Drug Combinations

General Information of This Drug (ID: DM3OWT4)

• Drug Name: Tindamax (DM3OWT4)
• Synonyms: Tinidazole (oral), Mission Pharmacal

Indication

Bacterial infection; ICD 11: 1A00-1C4Z; Status: Approved [1]; Bacterial vaginosis; ICD 11: MF3A; Status: Approved [2]; Trichomoniasis; ICD 11: N.A.; Status: Approved [3]; Giardiasis; ICD 11: N.A.; Status: Investigative [4]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

48 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aprepitant + Tindamax	DCQYWU1	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Arfolitixorin + Tindamax	DC1L1HF	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Brincidofovir + Tindamax	DCM6E18	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Chlormezanone + Tindamax	DCG90GK	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ciprofibrate + Tindamax	DCSF9YA	Ciprofibrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Clopidogrel + Tindamax	DCSPQSD	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Dantrolene + Tindamax	DC1GCE5	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Dextromethorphan + Tindamax	DCZMEHT	Dextromethorphan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Doxorubicin + Tindamax	DCM941G	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ezetimibe + Tindamax	DCLBOSF	Ezetimibe	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Imatinib + Tindamax	DCTJ1R2	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Lumefantrine + Tindamax	DCUK46J	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Maprotiline + Tindamax	DC9YEC6	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mebutamate + Tindamax	DCM7ULO	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mefloquine + Tindamax	DCV795G	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Metyrosine + Tindamax	DCR6FVM	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Miglustat + Tindamax	DC4MYYC	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Nabilone + Tindamax	DC1AFXY	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Niclosamide + Tindamax	DC6WWCU	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pyrazinamide + Tindamax	DCF6VJD	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ramelteon + Tindamax	DCSZD31	Ramelteon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Spironolactone + Tindamax	DCZD4IL	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Diethylcarbamazine	DCWPABF	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Epinephrine	DCITH2T	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Methotrexate	DCMJLCO	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Triapine	DCEKE15	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Pepstatin	DCY66O2	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Efavirenz	DC9IFMG	Efavirenz	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Chlorzoxazone	DC7KJYQ	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Memantine	DC069T7	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Daidzin	DCJ6MI9	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Pentamidine	DCZUYDJ	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + BIO-300	DCWY45C	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Tiagabine	DC9EQ9I	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Entacapone	DCKJT06	Entacapone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Idarubicin	DCA052Q	Idarubicin	Glioblastoma? (Cell Line: T98G)	[5]
Tindamax + Methylene blue	DCXOZ0F	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Clascoterone	DC0S3YZ	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Maprotiline	DCNT8O8	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Oxyphenbutazone	DCPIHM4	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Leflunomide	DC32QBP	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Acarbose	DCLGDPS	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Brincidofovir	DCTUOET	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Mycophenolic acid	DC5E0RL	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Hydroxychloroquine	DCW1FW9	Hydroxychloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Acetohydroxamic Acid	DC4P2UQ	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Trihexyphenidyl + Tindamax	DCM5YY5	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Vinblastine + Tindamax	DC4J6UV	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Tindamax + Doxycycline	DCKI84K	Doxycycline	Urethritis	[6]
Tindamax + Azithromycin	DCZLQOK	Azithromycin	Urethritis	[6]
Tindamax + Clarithromycin	DCY6M25	Clarithromycin	Helicobacter Infections	[7]
Tindamax + Esomeprazole	DCOADDT	Esomeprazole	Helicobacter Infection	[8]
Tindamax + Amoxicillin	DC88B5V	Amoxicillin	Antimicrobial Susceptibility Testing	[9]

References

• [1] 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
• [2] Tinidazole. 2021 Mar 17. Drugs and Lactation Database (LactMed?) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006C.
• [3] Tinidazole (Tindamax)--a new option for treatment of bacterial vaginosis. Med Lett Drugs Ther. 2007 Sep 10;49(1269):73-4.
• [4] Tinidazole (Tindamax) - a new anti-protozoal drug. Med Lett Drugs Ther. 2004 Aug 30;46(1190):70-2.
• [5] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [6] ClinicalTrials.gov (NCT00322465) NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole)
• [7] ClinicalTrials.gov (NCT04652284) Effectiveness of Rifabutin for Treatment of Helicobacter Pylori
• [8] ClinicalTrials.gov (NCT02711176) Comparison of Daily Single Dose Triple and Conventional Triple Therapies for Helicobacter Pylori Infection
• [9] ClinicalTrials.gov (NCT03139253) Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment