Details of the Drug Combinations

General Information of This Drug (ID: DM3UZ95)

Drug Name

Bisoprolol DM3UZ95

Synonyms

Bisocor; Bisoprololum; Cardicor; Concor; Detensiel; Emconcor; Emcor; Euradal; Isoten; Monocor; Soloc; Soprol; Zebeta; Bisoprolol fumerate; Bisoprolol hemifumarate; Bisoprololum [Latin]; CL-297939; Concor (TN); Concore (TN); EMD-33512; Monocor (TN); Zebeta (TN); Bisoprolol (USAN/INN); Bisoprolol [USAN:BAN:INN]; EMD-33-512; (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol; (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol; 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol; 1-[(1-methylethyl)amino]-3-({4-[({2-[(1-methylethyl)oxy]ethyl}oxy)methyl]phenyl}oxy)propan-2-ol; 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]
Malignant essential hypertension	BA00	Approved	[2]
------------------------------------------------------------------------------------

Therapeutic Class

Antihypertensive Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bisoprolol + Salbutamol	DCPE2SO	Salbutamol	Primary Hypertension	[3]
Ivabradine + Bisoprolol	DCFNVX5	Ivabradine	Heart Failure With Reduced Ejection Fraction	[4]
Bisoprolol + Ramipril	DCSN6WE	Ramipril	Breast Cancer	[5]
Bisoprolol + Atenolol	DCROI8S	Atenolol	Hypertension	[6]
------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7129).
2	Bisoprolol FDA Label
3	ClinicalTrials.gov (NCT01742702) HaemoDYNAMICs in Primary and Secondary Hypertension
4	ClinicalTrials.gov (NCT03701880) Early Use of Ivabradine in Heart Failure
5	ClinicalTrials.gov (NCT02236806) Cardiotoxicity Prevention in Breast Cancer Patients Treated With Anthracyclines and/or Trastuzumab
6	ClinicalTrials.gov (NCT01939509) Hemodynamic Changes of Patients Receiving Atenolol/Bisoprolol