Details of the Drug Combinations

General Information of This Drug (ID: DM4QTBN)

Drug Name

Isotretinoin DM4QTBN

Synonyms

Accutane; Amnesteem; Claravis; Isotane; Isotretinoine; Isotretinoino; Isotretinoinum; Isotrex; Roaccutan; Roaccutane; Roacutan; Sotret; Teriosal; Neovitamin A acid; R 3255; Ro 4 3780; Ro 43780; Accutane (TN); Amnesteem (TN); BML2-E07; CIP-Isotretinoin; Claravi (TN); Clarus (TN); Decutan (TN); Isotane (TN); Isotretinoin (USP); Isotretinoin Zinc Salt, 13 cis Isomer; Isotretinoine [INN-French]; Isotretinoino [INN-Spanish]; Isotretinoinum [INN-Latin]; Izotek (TN); Oratane (TN); Ro 4-3780; Ro-43780; Roaccutane (TN); Sotret (TN); Isotretinoin [USAN:INN:BAN]; Ro-4-3780; Isotretinoin Zinc Salt, 13-cis-Isomer; (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid; (2Z,4E6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid; (7E,9E,11E,13Z)-retinoic acid; 13-RA; 13-cis RA; 13-cis-Vitamin A acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[1]
Mycosis fungoides	2B01	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[3]
Neuroblastoma	2D11.2	Investigative	[2]
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Therapeutic Class

Antiacne Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

14 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Celecoxib + Isotretinoin	DCT30B6	Celecoxib	Brain and Central Nervous System Tumors	[4]
Isotretinoin + Procarbazine	DC1HX12	Procarbazine	Brain and Central Nervous System Tumors	[5]
Isotretinoin + Temozolomide	DC914WI	Temozolomide	Brain and Central Nervous System Tumors	[4]
Isotretinoin + Valaciclovir	DC9GYYF	Valaciclovir	Acne Scars - Mixed Atrophic and Hypertrophic	[6]
Isotretinoin + Interferon alfa-2B	DCH9EWH	Interferon alfa-2B	Lymphoma, T-Cell	[7]
Isotretinoin + Erlotinib	DCINDQI	Erlotinib	Adult Anaplastic Astrocytoma	[8]
Isotretinoin + Vorinostat	DCWAGZ7	Vorinostat	Recurrent Renal Cell Cancer	[9]
Isotretinoin + Paclitaxel	DCYIJUX	Paclitaxel	Lung Cancer	[10]
Isotretinoin + Vorinostat	DCZ8O53	Vorinostat	Childhood Acute Promyelocytic Leukemia (M3)	[11]
Isotretinoin + Temozolomide	DCU0JTG	Temozolomide	Glioblastoma Multiforme	[12]
Isotretinoin + Cabozantinib	DCR3V1M	Cabozantinib	Solid Tumor	[13]
Isotretinoin + Itraconazole	DCCXGFS	Itraconazole	Tinea	[14]
Isotretinoin + Terbinafine	DCRH29C	Terbinafine	Tinea	[14]
Isotretinoin + Minocycline	DCET9K3	Minocycline	Acne Vulgaris	[15]
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⏷ Show the Full List of 14 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7600).
2	Isotretinoin FDA Label
3	ClinicalTrials.gov (NCT04361422) Isotretinoin in Treatment of COVID-19. U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT00112502) Temozolomide Alone or in Combination With Thalidomide and/or Isotretinoin and/or Celecoxib in Treating Patients Who Have Undergone Radiation Therapy for Glioblastoma Multiforme
5	ClinicalTrials.gov (NCT00003564) Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas
6	ClinicalTrials.gov (NCT03514771) Early Non-Ablative Fractional Laser Resurfacing for Acne Scars After Treatment With Oral Isotretinoin
7	ClinicalTrials.gov (NCT00038376) Phase II Study Of Roferon and Accutane For Patients With T-Cell Malignancies
8	ClinicalTrials.gov (NCT01103375) Erlotinib Hydrochloride and Isotretinoin in Treating Patients With Recurrent Malignant Glioma
9	ClinicalTrials.gov (NCT00324740) Vorinostat and Isotretinoin in Treating Patients With Advanced Kidney Cancer
10	ClinicalTrials.gov (NCT00062010) Interferon Alfa, Isotretinoin, and Paclitaxel in Treating Patients With Recurrent Small Cell Lung Cancer
11	ClinicalTrials.gov (NCT00217412) Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia
12	ClinicalTrials.gov (NCT00555399) Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM)
13	ClinicalTrials.gov (NCT03611595) Cabozantinib in Combination With 13-cis-Retinoic Acid in Children With Relapsed or Refractory Solid Tumors
14	ClinicalTrials.gov (NCT03471455) Isotretinoin In Preventing Recurrences In Chronic Recurrent Dermatophytosis
15	ClinicalTrials.gov (NCT04940767) A Companion Treatment Study for Patients With Moderate to Severe Acne Vulgaris