Details of the Drug Combinations

General Information of This Drug (ID: DM4S3O8)

• Drug Name: Ertapenem (DM4S3O8)
• Synonyms: Ertapenem [INN]; Ertapenem (INN); Invanz (TN); (1R,5S,6S,8R,2'S,4'S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid; (4R,5S,6S)-3-((3S,5S)-5-((3-carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (4R,5S,6S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; (4R,5S,6S)-3-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Indication

Bacterial infection; ICD 11: 1A00-1C4Z; Status: Approved [1]; Endometritis; ICD 11: N.A.; Status: Approved [2]; Peptostreptococcus infectious disease; ICD 11: N.A.; Status: Approved [2]; Streptococcal pneumonia; ICD 11: N.A.; Status: Approved [2]

• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ertapenem + Ceftriaxone	DC8ZPFF	Ceftriaxone	Liver Abscess, Pyogenic	[3]
Ertapenem + Amoxicillin	DCSHRQ0	Amoxicillin	Pulmonary Tuberculosis	[4]
Ertapenem + Meropenem	DCCPIYG	Meropenem	Urinary Tract Infections	[5]

References

• [1] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [2] Ertapenem FDA Label
• [3] ClinicalTrials.gov (NCT01723150) Antibiotics for Klebsiella Liver Abscess Study
• [4] ClinicalTrials.gov (NCT05896930) Study to Evaluate EBA, Safety and Tolerability of Carbapenems in Adults With Pulmonary Tuberculosis
• [5] ClinicalTrials.gov (NCT03891433) Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic UTI Due to -ESBL-producing Enterobacteriaceae