Details of the Drug Combinations

General Information of This Drug (ID: DM51TYR)

Drug Name

Esmolol DM51TYR

Synonyms

ASL 8052-001; Brevibloc (TN); Esmolol (INN); Esmolol [INN:BAN]; Methyl p-[2-hydroxy-3-(isopropylamino)propoxy]hydrocinnamate; Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate; Methyl 3-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate; Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate; Methyl 3-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]propanoate; Methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate; Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester; (+-)-Esmolol; (+-)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate

Indication

Disease Entry	ICD 11	Status	REF
Acute supraventricular tachycardia	BC81	Approved	[1]
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Therapeutic Class

Antihypertensive Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Esmolol + Tecadenoson	DCF7Z76	Tecadenoson	Atrial Fibrillation	[2]
Esmolol + Labetalol	DCK8EQ6	Labetalol	Laparoscopic Surgery	[3]
Esmolol + Propofol	DCO9XF6	Propofol	Pain	[4]
Esmolol + Fentanyl	DCOE8M2	Fentanyl	Laparoscopic Surgery	[3]
Esmolol + Milrinone	DCZNSYY	Milrinone	Myocardial Reperfusion Injury	[5]
Esmolol + Lidocaine	DCEGK3Y	Lidocaine	Hemodynamic Instability	[6]
Esmolol + Rocuronium	DCQUXWV	Rocuronium	Injection Site Irritation	[7]
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⏷ Show the Full List of 7 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7178).
2	ClinicalTrials.gov (NCT00713401) Safety Study of Tecadenoson to Treat Atrial Fibrillation
3	ClinicalTrials.gov (NCT01114971) Labetalol and Esmolol: Vital Signs and Post Operative Pain Management
4	ClinicalTrials.gov (NCT01885364) Esmolol Pretreatment on Pain During Injection of Propofol
5	ClinicalTrials.gov (NCT02098629) Concomitant Milrinone and Esmolol Treatment in Patients With Acute Myocardial Infarction
6	ClinicalTrials.gov (NCT03612492) The Effects of Lidocaine and Esmolol on Attenuation of Hemodynamic Response to Orotracheal Intubation
7	ClinicalTrials.gov (NCT01824758) Effect of Esmolol on Pain Due to Rocuronium