Details of the Drug Combinations

General Information of This Drug (ID: DM5X7VY)

• Drug Name: Pyrimethamine (DM5X7VY)
• Synonyms: Chloridin; Chloridine; Chloridyn; Darachlor; Daraclor; Darapram; Daraprim; Daraprime; Daraprin; Diaminopyritamin; Erbaprelina; Ethylpyrimidine; Khloridin; Malacid; Malocid; Malocide; Maloprim; Pirimecidan; Pirimetamin; Pirimetamina; Primethamine; Pyremethamine; Pyrimethamin; Pyrimethaminum; Tindurin; Tindurine; Tinduring; Aventis Brand of Pyrimethamine; Glaxo Wellcome Brand of Pyrimethamine; GlaxoSmithKline Brand of Pyrimethamine; M alocid; Pirimetamina [Spanish]; Pyrimethamine Hcl; Wellcome Brand of Pyrimethamine; BW 5063; RP 4753; WR 2978; AZT + Pyrimethamine combination; BW 50-63; Daraprim (TN); EXR-101; Lactoferrin B & Pyrimethamine; Lactoferrin H & Pyrimethamine; Pirimetamina [INN-Spanish]; Pyrimethamine (Pyr); Pyrimethaminum [INN-Latin]; TCMDC-123831; TCMDC-125860; CRL-8131 & Pyrimethamine; CRL-8142 & Pyrimethamine; Fansidar (Pyrimethamine/Sulfadoxine); Pyrimethamine (JAN/USP/INN); Pyrimethamine [USAN:INN:BAN:JAN]; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine; 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine; 5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE; 5-(4-CHLOROPHENYL)-6-ETHYL-2,4-PYRIMIDINEDIAMINE; 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidi nediamine; 5-(4-chlorophenyl)-2,4-diamino-6-ethylpyrimidine; 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; 5-(p-chlorophenyl)-6-ethyl-2,4-diaminopyrimidine; 5-[4-Chlorophenyl]-6-ethyl-2,4-pyrimidinediamine

Indication

Malaria; ICD 11: 1F40-1F45; Status: Approved [1]

• Therapeutic Class: Antimalarials
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

14 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Doxepin + Pyrimethamine	DC8C7WP	Doxepin	Hepatoblastoma (Cell Line: HB3)	[2]
Pyrimethamine + Lumefantrine	DCFU6NO	Lumefantrine	DD2 (Cell Line: DD2)	[3]
Pyrimethamine + Lumefantrine	DC66YG2	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Pyrimethamine + T-3.5	DC13WUT	T-3.5	DD2 (Cell Line: DD2)	[3]
Pyrimethamine + Diltiazem	DCWIXUG	Diltiazem	Hepatoblastoma (Cell Line: HB3)	[3]
Pyrimethamine + Miconazole	DCY86ZW	Miconazole	Hepatoblastoma (Cell Line: HB3)	[3]
Pyrimethamine + NITD609	DCUFO9Z	NITD609	DD2 (Cell Line: DD2)	[3]
Pyrimethamine + MK-4815	DCNJSQH	MK-4815	DD2 (Cell Line: DD2)	[3]
Pyrimethamine + MK-4815	DCPBDWG	MK-4815	Hepatoblastoma (Cell Line: HB3)	[3]
Pyrimethamine + Nitisinone	DC8UEX6	Nitisinone	Hepatoblastoma (Cell Line: HB3)	[3]
Pyrimethamine + Atovaquone	DCRO09I	Atovaquone	DD2 (Cell Line: DD2)	[3]
Pyrimethamine + Atovaquone	DCBSQQ2	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[3]
Pyrimethamine + Ibrutinib	DCVQFAN	Ibrutinib	Diffuse large B cell lymphoma (Cell Line: TMD8)	[3]
Sorafenib + Pyrimethamine	DC6X059	Sorafenib	DD2 (Cell Line: DD2)	[3]

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Pyrimethamine + Leucovorin	DC9DZ77	Leucovorin	Gangliosidoses, GM2	[4]
Pyrimethamine + Leucovorin	DC8AF7L	Leucovorin	Toxoplasmosis	[5]
Pyrimethamine + Valproic Acid	DCBBK0X	Valproic Acid	HIV-1-infection	[6]
Pyrimethamine + Chloroquine	DCQ5UUQ	Chloroquine	Malaria	[7]
Spiramycin + Pyrimethamine	DCH1F79	Spiramycin	Toxoplasmosis	[8]

1 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Pyrimethamine + Sulphadoxine	DC03JFJ	Sulphadoxine	Pneumocystis pneumonia	[9]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4800).
• [2] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT01102686) Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease)
• [5] ClinicalTrials.gov (NCT03258762) Phase I Study of Pyrimethamine in Healthy Japanese and Caucasian Subjects
• [6] ClinicalTrials.gov (NCT03525730) LRAs United as a Novel Anti-HIV Strategy.
• [7] ClinicalTrials.gov (NCT02511054) Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B...
• [8] ClinicalTrials.gov (NCT00004317) Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis
• [9] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015