Details of the Drug Combinations

General Information of This Drug (ID: DM5ZVLB)

Drug Name
Ixazomib   DM5ZVLB
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Approved [1]
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

23 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + Ixazomib DC48DXX ABT-263 Glioblastoma (Cell Line: JHH-136) [2]
Alvespimycin hydrochloride + Ixazomib DCRPASH Alvespimycin hydrochloride Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Bardoxolone methyl + Ixazomib DCIS62O Bardoxolone methyl Glioblastoma (Cell Line: JHH-136) [3]
BMS-754807 + Ixazomib DCNNSIO BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Buparlisib + Ixazomib DCNUSCU Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Cladribine + Ixazomib DC1JUOP Cladribine Glioblastoma (Cell Line: JHH-136) [3]
Doxorubicin + Ixazomib DCRAUAX Doxorubicin Glioblastoma (Cell Line: JHH-136) [3]
Evacetrapib + Ixazomib DCJW95V Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Everolimus + Ixazomib DC10QA6 Everolimus Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Fenretinide + Ixazomib DC4C0XI Fenretinide Glioblastoma (Cell Line: JHH-136) [3]
GSK2126458 + Ixazomib DCKI5E0 GSK2126458 Glioblastoma (Cell Line: JHH-136) [3]
Ixazomib + Carfilzomib DCDP1F3 Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Ixazomib + Carfilzomib DC8YF94 Carfilzomib Glioblastoma (Cell Line: JHH-136) [3]
Ixazomib + Panobinostat DCAOSIC Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Ixazomib + Ruxolitinib DC274MQ Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
JQ1 + Ixazomib DCOBPZE JQ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
MK-1775 + Ixazomib DCUK2QA MK-1775 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
PAC1 + Ixazomib DCVS3M3 PAC1 Glioblastoma (Cell Line: JHH-136) [3]
Pyrazinamide + Ixazomib DCFFK7I Pyrazinamide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Selumetinib + Ixazomib DCYJRX0 Selumetinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
TAK-733 + Ixazomib DC4HPMP TAK-733 Glioblastoma (Cell Line: JHH-136) [3]
THAPSIGARGIN + Ixazomib DCA9N31 THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Vincristine + Ixazomib DC3ZWFB Vincristine Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
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⏷ Show the Full List of 23 DrugCom(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2015
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.