Details of the Drug Combinations

General Information of This Drug (ID: DM6AUHV)

Drug Name
Fostamatinib   DM6AUHV
Synonyms 901119-35-5; R788; Tavalisse; UNII-SQ8A3S5101; R-788 Free acid; R 788; R-788; R-935788 Free acid; SQ8A3S5101; R7935788; Fostamatinib [USAN:INN]
Indication
Disease Entry ICD 11 Status REF
Immune thrombocytopenic purpura 3B64.13 Approved [1]
Rheumatoid arthritis FA20 Phase 3 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

15 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
CA4P + Fostamatinib DCIANR9 CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + JQ1 DC83XBH JQ1 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + Panobinostat DCJZZ7M Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Fostamatinib + Cantharidin DCVPUTE Cantharidin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + THAPSIGARGIN DCNRAB0 THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + Marizomib DCCBSZN Marizomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + Mifepristone DCRVQT1 Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + SNDX-275 DC2HI8C SNDX-275 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + Tamoxifen DCDVTWK Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + Ciclopirox DCC24WX Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + MLN8237 DC0XK8K MLN8237 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + IMD-0354 DCTDUIQ IMD-0354 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + BMS-754807 DC2ZSP5 BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Fostamatinib + Prazosin DC9XT4O Prazosin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Raloxifene + Fostamatinib DCAQREV Raloxifene Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
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⏷ Show the Full List of 15 DrugCom(s)
8 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Fostamatinib + Rosuvastatin DC3PON3 Rosuvastatin Rheumatoid Arthritis [4]
Fostamatinib + Verapamil DCVQ9JN Verapamil Drug Drug Interactions [5]
Fostamatinib + Warfarin DCWG8B5 Warfarin Rheumatoid Arthritis [6]
Ranitidine + Fostamatinib DC5B6G0 Ranitidine Pharmacokinetics [7]
Rifampicin + Fostamatinib DC5G79Z Rifampicin Rheumatoid Arthritis [8]
Ruxolitinib + Fostamatinib DCLT6AX Ruxolitinib Chronic Graft Versus Host Disease [9]
Simvastatin + Fostamatinib DCH0Q7G Simvastatin Rheumatoid Arthritis [4]
Ruxolitinib + Fostamatinib DCRSIRU Ruxolitinib Myelofibrosis [10]
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⏷ Show the Full List of 8 DrugCom(s)

References

1 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7796).
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT01725230) Assess the Pharmacokinetics of Rosuvastatin and Simvastatin When Administered Alone or in Combination With Fostamatinib
5 ClinicalTrials.gov (NCT01197781) Evaluation of the Drug-drug Interaction Between FosD and Verapamil When Taken Together in Healthy Volunteers
6 ClinicalTrials.gov (NCT01311622) Effects of Administration of Fostamatinib on Blood Concentrations of Warfarin in Healthy Subjects
7 ClinicalTrials.gov (NCT01682408) Assess Pharmacokinetics of Fostamatinib in Fed and Fasted State in Combination With Ranitidine to Assess Bioavailability
8 ClinicalTrials.gov (NCT01336218) Effects of Administration of Fostamatinib on Blood Concentrations of Rifampicin in Healthy Subjects.
9 ClinicalTrials.gov (NCT06233110) Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD
10 ClinicalTrials.gov (NCT04543279) Fostamatinib as a Single Agent or in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis With Severe Thrombocytopenia