Details of the Drug Combinations

General Information of This Drug (ID: DM6HX9B)

• Drug Name: Nevirapine (DM6HX9B)
• Synonyms: NEV; NVP; Viramune; Cahill May Roberts Brand of Nevirapine; Promeco Brand of Nevirapine; BI RG 587; BIRG 0587; BIRG 587; BIRG587; BIRG-0587; BIRG-587; NON-NUCLEOSIDE RT INHIBITOR NEVIRAPINE; Nevirapine & PRO 140; Nevirapine [USAN:INN]; Viramune (TN); Viramune(TM); BI-RG-587; Nevirapine & CD4-IgG; Nevirapine (JAN/USP/INN); Viramune, BI-RG 587, Nevirapine; BI-RG-587 & CD4-IgG; N11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e]-[1,4]diazepin-6-one & CD4-immunoadhesin; 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one; 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one & PRO 140 (Anti-CCR5 monoclonal antibody); 11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one; 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one

Indication

Human immunodeficiency virus infection; ICD 11: 1C62; Status: Approved [1]

• Therapeutic Class: Anti-HIV Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Nevirapine + Idarubicin	DCOQ1FN	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
Nevirapine + Ruxolitinib	DCWT0SC	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]

11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Levonorgestrel + Nevirapine	DCZO5AK	Levonorgestrel	HIV	[4]
Nevirapine + Efavirenz	DCSMO90	Efavirenz	HCV Infection.	[5]
Rifampicin + Nevirapine	DCU1EM3	Rifampicin	Tuberculosis	[6]
Tenofovir disoproxil + Nevirapine	DCJWKXM	Tenofovir disoproxil	HIV Infections	[7]
Nevirapine + Lamivudine	DCT6FBL	Lamivudine	HIV Infections	[8]
Zidovudine + Nevirapine	DC0IUI3	Zidovudine	HIV	[9]
Zidovudine + Nevirapine	DC88ICA	Zidovudine	HIV Infections	[10]
Nevirapine + Atazanavir	DCSVZKV	Atazanavir	HIV Infections	[11]
Nevirapine + Fluconazole	DCRD6FO	Fluconazole	HIV Infections	[12]
Rifabutin + Nevirapine	DCKX0CV	Rifabutin	HIV Infections	[13]
Zidovudine + Nevirapine	DCWDFWL	Zidovudine	HIV/AIDS and Infections	[14]

References

• [1] Approved antiretroviral drugs. Antiretroviral Drugs. Company report of AVERT. 2009.
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] ClinicalTrials.gov (NCT01789879) A Pharmacokinetic Evaluation of Levonorgestrel Implant and Antiretroviral Therapy
• [5] ClinicalTrials.gov (NCT01277627) Influence of Nevirapine on HCV Viral Load
• [6] ClinicalTrials.gov (NCT00495326) Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146 CARINEMO)
• [7] ClinicalTrials.gov (NCT00260078) Blood Levels of Anti-HIV Drugs Used in Combination Regimens in HIV Infected Children
• [8] ClinicalTrials.gov (NCT02116660) Evaluation of Renal Function, Efficacy, and Safety When Switching From Tenofovir/Emtricitabine Plus a Protease Inhibitor/Ritonavir, to a Combination of Raltegravir (MK-0518) Plus Nevirapine Plus Lamivudine in HIV-1 Participants With Suppressed Viremia and Impaired Renal Function (MK-0518-284)
• [9] ClinicalTrials.gov (NCT02369406) Early Infant HIV Treatment in Botswana
• [10] ClinicalTrials.gov (NCT00307151) Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV
• [11] ClinicalTrials.gov (NCT00355719) Study to Evaluate the Influence of Nevirapine to Atazanavir in Steady State Equilibrium in HIV Patients
• [12] ClinicalTrials.gov (NCT02181946) Effects of Nevirapine on the Steady State Pharmacokinetics of Fluconazole in HIV Positive Patients
• [13] ClinicalTrials.gov (NCT02184078) Study to Determine the Effects of Nevirapine (VIRAMUNE) on the Steady State Pharmacokinetics of Rifabutin (MYCOBUTIN) in HIV+ Patients
• [14] ClinicalTrials.gov (NCT02712801) Antiretroviral Regime for Viral Eradication in Newborns