Details of the Drug Combinations

General Information of This Drug (ID: DM6IR3P)

Drug Name

Liothyronine DM6IR3P

Synonyms

liothyronine; 3,3',5-Triiodo-L-thyronine; 6893/2/3; Liothyronin; Tresitope; 3,5,3'-triiodothyronine; L-Liothyronine; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; triothyrone; Liothyroninum; Liotironina; 3,5,3'-Triiodo-L-thyronine; L-T3; T3; 3,3',5-Triiodothyronine; Triiodo-L-thyronine; Lyothyronine; 3,5,3'TRIIODOTHYRONINE; L-3,5,3'-Triiodothyronine; (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid; T3 (amino acid); T3 (Hormone); L-3,3',5-TriioDOThyronine; Liothyronine [INN:BAN]; Rathyronine; Triothyrone; THYROID HORMONE; Liothyronine I 131; Liothyronine I 131 [USAN]; T3 liothyronine; Cytomel (TN); Euthroid-1; Euthroid-2; Euthroid-3; Liothyronine (INN); Liothyroninum[INN-Latin]; Liotironina [INN-Spanish]; T3 (Triiodothyronine); T3 (VAN); Tertroxin (TN); Thyrolar-1; Thyrolar-2; Thyrolar-3; Tri-Thyrotope; Triiodothyronine (T3); Triomet-131; Euthroid-05; Thyrolar-025; Thyrolar-05; TRIIODOTHYRONINE (T3 OR LIOTHYRONINE, ACTIVE) (6-11%); Thyronine, 3,3',5-triiodo-, L-(6CI); L-3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine; L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-(9CI); 3,3'5-Triiodo-L-thyronine; 3,5,3'-Tri-iodo-L-thyronine; 4-(3-Iodo-4-hydroxyphenoxy)-3,5-diiodophenylalanine; 4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylalanine; 4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine

Indication

Disease Entry	ICD 11	Status	REF
Congenital hypothyroidism	N.A.	Approved	[1]
Edema	MG29	Approved	[1]
Goiter	N.A.	Approved	[1]
Hypothyroidism	5A00	Approved	[2]
Thyroid cancer	2D10	Approved	[1]
Congestive heart failure	BD10	Phase 3	[3]
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Therapeutic Class

Hormone Replacement Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Liothyronine + Protirelin	DCFHZH4	Protirelin	Subclinical Hypothyroidism	[4]
Liothyronine + Valproic Acid	DC2HOCZ	Valproic Acid	Thyroid Neoplasm	[5]
Liothyronine + Levothyroxine	DC3GBOE	Levothyroxine	Hypothyroidism	[6]
Methimazole + Liothyronine	DC1N1VM	Methimazole	Recurrent Glioblastoma	[7]
Sertraline + Liothyronine	DCIB9X3	Sertraline	Major Depression	[8]
Liothyronine + Levothyroxine	DCS5BIQ	Levothyroxine	Thyroid Goiter	[9]
Liothyronine + Tranylcypromine	DC51VK7	Tranylcypromine	Major Depression	[10]
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References

1	Liothyronine FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	ClinicalTrials.gov (NCT00790738) Liothyronine (T3) for Bipolar Depression. U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT02399475) Mechanistic Study of Subclinical Hypothyroidism In the Elderly
5	ClinicalTrials.gov (NCT01182285) A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin
6	ClinicalTrials.gov (NCT00488644) Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors
7	ClinicalTrials.gov (NCT05017610) Inducing a Hypothyroxinemic State in Patients With Recurrent Glioblastoma or Gliosarcoma
8	ClinicalTrials.gov (NCT00208702) Thyroid Medication and Antidepressants for Treating Major Depression
9	ClinicalTrials.gov (NCT04782856) Energy Metabolism in Thyroidectomized Patients
10	ClinicalTrials.gov (NCT00296686) Sequential Tranylcypromine (TC), TC + Dextroamphetamine and TC + Triiodothyronine for Refractory Depression