Details of the Drug Combinations

General Information of This Drug (ID: DM6RZ9Q)

• Drug Name: Clonidine (DM6RZ9Q)
• Synonyms: clonidine; Clonidin; Duraclon; Chlornidinum; 4205-90-7; Catapres-TTS; Catarpresan; Catarpres; Adesipress; Catapres; Catapressan; Catapresan; ST 155BS; ST-155-BS; Clonidinum; Clonidina; Clonidinum [INN-Latin]; Clonidinhydrochlorid; CATAPRES-TTS-3; CATAPRES-TTS-1; CATAPRES-TTS-2; N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine; Isoglaucon; 2-(2,6-Dichloroanilino)-2-imidazoline; Dixarit; SKF 34427; Catapres- TTS; Clonidina [INN-Spanish]; M-5041T; Hemiton; CLORPRES; clonidine (amino form); Adesipress; Clofenil; Clopheline; Duraclont; Gemiton; Klofelin; Klofenil; M 5041T; Catapres (TN); Catarpres-TTS; ST-155BS; Tenso-Timelets; Catarpres-TTS (TN); Clonidine [USAN:BAN:INN]; Clonidine (JAN/USAN/INN); 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro-(9CI); 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine; 2,6-dichloro-N-(2-imidazolidinylidene)aniline; 2,6-dichloro-N-2-imidazolidinylidenebenzenamide; 2,6-dichloro-N-imidazolidin-2-ylideneaniline; 2-((2,6-Dichlorophenyl)imino)imidazolidine; 2-(2,6-Dichloroanilino)-1,3-diazacyclopentene-(2);2-(2,6-Dichloroanilino)-2-imidazoline; 2-(2,6-Dichlorophenylamino)-2-imidazoline; 2-(2,6-Dichlorophenylimino)imidazolidine; 2-Imidazoline, 2-(2,6-dichloroanilino)-(7CI,8CI); 2-[(2,6-Dichlorophenyl)imino]imidazoline; 2-[(2,6-dichlorophenyl)imino]-2-imidazoline; 734571A; 2,6-DICHLORO-N-IMIDAZOLIDIN-2-YLIDENEANILINE

Indication

Attention deficit hyperactivity disorder; ICD 11: 6A05.Z; Status: Approved [1]; Hypertension; ICD 11: BA00-BA04; Status: Approved [2]; Neonatal abstinence syndrome; ICD 11: N.A.; Status: Approved [1]; Diabetic neuropathy; ICD 11: 8C0Z; Status: Phase 3 [3]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clonidine + Idarubicin	DCL7I1P	Idarubicin	Glioblastoma? (Cell Line: T98G)	[4]

16 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clonidine + Lorazepam	DC648ND	Lorazepam	Opiate Addiction	[5]
Clonidine + Gabapentin	DC6OIUO	Gabapentin	Shoulder Arthroscopy	[6]
Clonidine + Ropivacaine	DCCZT10	Ropivacaine	Postoperative Pain	[7]
Clonidine + Sevoflurane	DCMP1JA	Sevoflurane	Surgery	[8]
Clonidine + Levobupivacaine	DCSSXSU	Levobupivacaine	Knee Osteoarthritis	[9]
Clonidine + Lidocaine	DCUCYTI	Lidocaine	Pilonidal Sinus	[10]
Ketamine + Clonidine	DC24WFO	Ketamine	Depressive Disorder, Treatment-Resistant	[11]
Naloxone + Clonidine	DCUH0KL	Naloxone	Experimental Pain Perception	[12]
Clonidine + Levobupivacaine	DCARI40	Levobupivacaine	Anesthesia, Epidural	[13]
Clonidine + Colesevelam	DCIVMRY	Colesevelam	Fecal Incontinence	[14]
Clonidine + Enalapril	DC88923	Enalapril	Hypertension	[15]
Clonidine + Ropivacaine	DCREFBA	Ropivacaine	Anterior Cruciate Ligament Injury	[16]
Clonidine + Telmisartan	DCY8FT8	Telmisartan	Hypertension	[15]
Epinephrine + Clonidine	DCD09A2	Epinephrine	Total Hip and Knee Arthroplasty	[17]
Epinephrine + Clonidine	DC0MOL2	Epinephrine	Hip Dysplasia	[18]
Ketamine + Clonidine	DCIZ4US	Ketamine	Postoperative Pain	[19]

References

• [1] Clonidine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 516).
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [5] ClinicalTrials.gov (NCT02362256) The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism
• [6] ClinicalTrials.gov (NCT01112878) Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery
• [7] ClinicalTrials.gov (NCT02439281) Ropivacaine With Clonidine For Pediatric Rectus Sheath Blocks- The Magic Combination
• [8] ClinicalTrials.gov (NCT06287151) Regional Anesthesia EMG Study
• [9] ClinicalTrials.gov (NCT02695654) Effectiveness of Ultrasound Guided Adductor Canal Block on Chronic Pain in Knee Osteoarthritis
• [10] ClinicalTrials.gov (NCT02539693) Sacrococcygeal Local Anesthesia With Different Doses of Clonidine for Pilonidal Sinus Surgery
• [11] ClinicalTrials.gov (NCT01179009) Treatment Resistant Depression (Pilot)
• [12] ClinicalTrials.gov (NCT01851486) The Relationships Between the Noradrenergic, Opioid and Pain System
• [13] ClinicalTrials.gov (NCT02563821) Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)
• [14] ClinicalTrials.gov (NCT02628626) A Study of Colesevelam in Fecal Incontinence
• [15] ClinicalTrials.gov (NCT02177461) Telmisartan Compared With Enalapril in Elderly Patients With Blood Hypertension
• [16] ClinicalTrials.gov (NCT03704376) Clinical Comparison of Femoral Nerve Versus Adductor Canal Block Following Anterior Ligament Reconstruction
• [17] ClinicalTrials.gov (NCT02543801) A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty
• [18] ClinicalTrials.gov (NCT02365961) Hip Scope Fascia-iliaca (FI) Block Study
• [19] ClinicalTrials.gov (NCT03124082) OFA - Opioid Free Anesthesia