Details of the Drug Combinations

General Information of This Drug (ID: DM70BU5)

• Drug Name: Thalidomide (DM70BU5)
• Synonyms: Algosediv; Asmadion; Asmaval; Bonbrain; Bonbrrin; Calmore; Calmorex; Contergan; Corronarobetin; Distaval; Distaxal; Distoval; Ectiluran; Enterosediv; Gastrinide; Glupan; Glutanon; Grippex; Hippuzon; Imidene; Isomin; Kedavon; Kevadon; Neaufatin; Neosedyn; Neosydyn; Nerosedyn; Neufatin; Neurodyn; Neurosedin; Neurosedym; Neurosedyn; Nevrodyn; Nibrol; Noctosediv; Noxodyn; Pangul; Pantosediv; Polygripan; Profarmil; Psycholiquid; Psychotablets; Quetimid; Quietoplex; Sandormin; Sedalis; Sedimide; Sedin; Sedisperil; Sedoval; Shinnibrol; Sleepan; Slipro; Softenil; Softenon; Synovir; Talargan; Talidomida; Talidomide; Talimol; Talismol; Talizer; Telagan; Telargan; Telargean; Tensival; Thaled; Thalidomidum; Thalin; Thalinette; Thalomid; Thalomide; Theophilcholine; Valgis; Valgraine; Yodomin; Celgene Brand of Thalidomide; Talidomide [DCIT]; Thalidomide Celgene; Thalidomide Pharmion; Asidon 3; ENMD 0995; IN1061; Thalidomine USP26; Alpha-Phthalimidoglutarimide; E-217; Imida-lab; Imidan (peyta); N-Phthalimidoglutamic acid imide; N-Phthaloylglutamimide; N-Phthalylglutamic acid imide; Poly-Giron; Predni-Sediv; Pro-Bam M; Pro-ban M; Sedalis sedi-lab; Shin-naito S; THALIDOMIDE (AIDS INITIATIVE); Talidomida [INN-Spanish]; Thaled (TN); Thalidomide (soluble form); Thalidomidum [INN-Latin]; Thalomid (TM); Thalomid (TN); Thalomid, Thalidomide; Alpha-N-Phthalylglutaramide; Thalidomide [USAN:INN:BAN]; Alpha-(N-Phthalimido)glutarimide; N-Phthalyl-glutaminsaeure-imid; N-Phthalyl-glutaminsaeure-imid [German]; Thalidomide (+ and-); Thalidomide (JAN/USP/INN); N-(2,6-Dioxo-3-piperidyl)phthalimide; (+)-Thalidomide; (+-)-Thalidomide; (+/-)-THALIDOMIDE; (inverted question mark)-Thalidomide; 2,6-Dioxo-3-phthalimidopiperidine; 3-Phthalimidoglutarimide

Indication

Adult T-cell leukemia/lymphoma; ICD 11: N.A.; Status: Approved [1]; Advanced cancer; ICD 11: 2A00-2F9Z; Status: Approved [1]; Complex regional pain syndrome type 1; ICD 11: N.A.; Status: Approved [1]; Hepatosplenic T-cell lymphoma; ICD 11: N.A.; Status: Approved [1]; Large granular lymphocytic leukemia; ICD 11: 2A90.1; Status: Approved [1]; Leukemia; ICD 11: N.A.; Status: Approved [1]; MALT lymphoma; ICD 11: N.A.; Status: Approved [1]; Multiple myeloma; ICD 11: 2A83; Status: Approved [2]; Nodal marginal zone lymphoma; ICD 11: 2A85.0; Status: Approved [1]; Pain; ICD 11: MG30-MG3Z; Status: Approved [1]; Plasma cell myeloma; ICD 11: 2A83.1; Status: Approved [1]; Primary cutaneous peripheral T-cell lymphoma not otherwise specified; ICD 11: N.A.; Status: Approved [1]; Prolymphocytic leukaemia; ICD 11: 2A82.1; Status: Approved [1]; Recurrent adult burkitt lymphoma; ICD 11: 2A85.6; Status: Approved [1]; Small intestine lymphoma; ICD 11: N.A.; Status: Approved [1]; Splenic marginal zone lymphoma; ICD 11: N.A.; Status: Approved [1]; Testicular lymphoma; ICD 11: N.A.; Status: Approved [1]; Urinary bladder neoplasm; ICD 11: N.A.; Status: Approved [1]; Waldenstrom macroglobulinemia; ICD 11: 2A85.4; Status: Approved [1]; Coronavirus Disease 2019 (COVID-19); ICD 11: 1D6Y; Status: Phase 2 [3]; Colon cancer; ICD 11: 2B90.Z; Status: Investigative [1]

• Therapeutic Class: Immunosuppressive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Thalidomide + Oblimersen	DCZ691Y	Oblimersen	Multiple myeloma (Cell Line: .)	[4]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Thalidomide + NV-07a	DC8AFVH	NV-07a	Coronavirus Disease 2019 (COVID-19)	[5]

References

• [1] Thalidomide FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7327).
• [3] ClinicalTrials.gov (NCT04273529) The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia. U.S. National Institutes of Health.
• [4] Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
• [5] ClinicalTrials.gov (NCT04273581) The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe COVID-19. U.S. National Institutes of Health.