Details of the Drug Combinations

General Information of This Drug (ID: DM79NTF)

• Drug Name: Propranolol (DM79NTF)
• Synonyms: Anaprilin; Anapriline; Avlocardyl; Bedranol; Berkolol; Betachron; Betadren; Betalong; Caridolol; Corpendol; Dociton; Efektolol; Etalong; Euprovasin; Herzbase; Ikopal; Inderal; Inderalici; Inderex; Inderol; Intermigran; Kemi; Migrastat; Naprilin; Obsidan; Obzidan; Pranolol; Pronovan; Propanalol; Propanix; Propanolol; Propranalol; Propranololo; Propranololum; Proprasylyt; Reducor; Sawatal; Servanolol; Sumial; Beta Neg; Inderal hydrochloride; Kemi S; Propranolol Hcl Intensol; Propranololo [DCIT]; Racemic propranolol; Reducorline; AY 64043; AY-20694; Anaprilinum (TN); Avlocardyl (TN); Beta-Propranolol; Beta-Tablinen; Beta-Timelets; DL-Propranolol hydrochloride; Deralin (TN); Dociton (TN); Inderal (TN); Inderal LA (TN); Inderalici (TN); InnoPran XL (TN); Propanolol [INN-Spanish]; Propranolol (INN); Propranolol (TN); Propranolol [INN:BAN]; Propranololum [INN-Latin]; Sumial (TN); D,L-Propranolol; INDERIDE-40/25; R,S-Propranolol Hydrochloride; (+-)-Propranolol; (1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol; (R)-(+)-propranolol; (S)-(-)-PROPRANOLOL; 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol; 1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane; 1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol; 1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol; 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol; 1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol; 1-Isopropylamino-3-(1-naphthyloxy)-2-propanol; 1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol; 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol; 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-(9CI); 2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)-(9CI); 3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol

Indication

Angina pectoris; ICD 11: BA40; Status: Approved [1]; Atrial fibrillation; ICD 11: BC81.3; Status: Approved [1]; Cocaine addiction; ICD 11: 6C45.2; Status: Approved [1]; Hemangioma; ICD 11: 2E81-2F2Y; Status: Approved [1]; Migraine; ICD 11: 8A80; Status: Approved [2]; Respiratory papillomatosis; ICD 11: 2F00.1; Status: Investigative [1]

• Therapeutic Class: Antianxiety Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

21 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Propranolol + Salbutamol	DC448PB	Salbutamol	Pulmonary Disease, Chronic Obstructive	[3]
Propranolol + Midodrine	DCCL3B5	Midodrine	Decompensated Cirrhosis	[4]
Propranolol + Prednisolone	DCEWV0P	Prednisolone	Hemangioma	[5]
Propranolol + Oxytocin	DCH6BK8	Oxytocin	Postpartum Hemorrhage	[6]
Propranolol + Amantadine	DCRITW0	Amantadine	Cocaine-Related Disorders	[7]
Propranolol + Midazolam	DCTA0ZI	Midazolam	Extrusion of Tooth	[8]
Propranolol + Warfarin	DCUW2BL	Warfarin	Portal Vein Thrombosis	[9]
Propranolol + Isoproterenol	DCQK95J	Isoproterenol	Obesity	[10]
Propranolol + Naltrexone	DCC2RVR	Naltrexone	Advanced Melanoma	[11]
Propranolol + Modafinil	DCNSVIM	Modafinil	Postural Tachycardia Syndrome	[12]
Propranolol + Prazosin	DCPAPQW	Prazosin	Post-traumatic Stress Disorder (PTSD)	[13]
Propranolol + Fenofibrate	DC5CGEG	Fenofibrate	Burn	[14]
Propranolol + Misoprostol	DC6L6QJ	Misoprostol	Induction of Labor Affected Fetus / Newborn	[15]
Propranolol + Duloxetine	DC8NCAP	Duloxetine	Low Back Pain	[16]
Propranolol + Sunitinib	DCGQX9W	Sunitinib	Renal Cell Carcinoma	[17]
Propranolol + Rosuvastatin	DCVSF6Y	Rosuvastatin	Cirrhosis	[18]
Propranolol + Ceftriaxone	DCXUVAW	Ceftriaxone	Stroke	[19]
Propranolol + Alendronate	DC4BOBC	Alendronate	Beta Blocker Toxicity	[20]
Propranolol + Warfarin	DCKKWD5	Warfarin	Portal Vein, Cavernous Transformation of	[21]
Propranolol + Oxytocin	DCRWUJM	Oxytocin	Poor; Labor	[22]
Methimazole + Propranolol	DC2BNAX	Methimazole	Graves Disease	[23]

References

• [1] Propranolol FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7596).
• [3] ClinicalTrials.gov (NCT00549120) Optimising the Propranolol Block Model
• [4] ClinicalTrials.gov (NCT04208776) Efficacy of Combination of Midodrine With Propranolol in Preventing First Bleed in Decompensated Cirrhotics With Severe Ascites.
• [5] ClinicalTrials.gov (NCT01074437) Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH)
• [6] ClinicalTrials.gov (NCT03434444) In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol
• [7] ClinicalTrials.gov (NCT00158132) Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2
• [8] ClinicalTrials.gov (NCT03388957) Oral Propranolol for Reducing Pediatric Dental Patients Anxiety
• [9] ClinicalTrials.gov (NCT02485184) TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis
• [10] ClinicalTrials.gov (NCT05219799) Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
• [11] ClinicalTrials.gov (NCT05968690) Naltrexone and Propranolol Combined With Immunotherapy
• [12] ClinicalTrials.gov (NCT01988883) Modafinil and Cognitive Function in POTS
• [13] ClinicalTrials.gov (NCT05189977) A Trial to Assess the Effects of Prazosin or Propranolol on Blood Pressure in the Presence of Brexpiprazole/Sertraline
• [14] ClinicalTrials.gov (NCT02452255) Fenofibrate and Propranolol in Burn Patients
• [15] ClinicalTrials.gov (NCT04533841) Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor in Primigravidas
• [16] ClinicalTrials.gov (NCT03364075) Genetic Variants Associated With Low Back Pain and Their Response to Treatment With Duloxetine or Propranolol
• [17] ClinicalTrials.gov (NCT03323710) Study of Propranolol Plus Sunitinib in First-line Treatment of Metastatic Renal Cell Carcinoma
• [18] ClinicalTrials.gov (NCT03720067) Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension
• [19] ClinicalTrials.gov (NCT05375240) Propranolol on Post Stroke Immune Status and Infection
• [20] ClinicalTrials.gov (NCT04704947) Clinical Study Evaluating Beta Blockers Use and Fracture Risk in Patients With Primary Osteoporosis
• [21] ClinicalTrials.gov (NCT02853526) TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
• [22] ClinicalTrials.gov (NCT02702674) The Effect of Coadministration of Oral Propranolol to Oxytocin on Induction of Labor
• [23] ClinicalTrials.gov (NCT01458600) Adjuvant Treatment of Graves Ophthalmopathy With NSAID (aGO Study)