Details of the Drug Combinations

General Information of This Drug (ID: DM7CLEZ)

Drug Name
Eltanexor oral   DM7CLEZ
Synonyms
KPT-8602; Eltanexor; UNII-Q59IQJ9NTK; Q59IQJ9NTK; 1642300-52-4; Eltanexor [INN]; Eltanexor [WHO-DD]; SCHEMBL16324809; MolPort-044-830-659; s8397; AKOS032945053; CS-5947; HY-100423; (E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)acrylamide; 5-Pyrimidineacetamide, alpha-((3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)methylene)-, (alphaE)-; (2E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)prop-2-enamide
Indication
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 1/2 [1]
Myelodysplastic syndrome 2A37 Phase 1/2 [1]
Prostate cancer 2C82.0 Phase 1/2 [1]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

37 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Eltanexor oral DCO1CGT (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + Eltanexor oral DC2564G ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
AT7519 + Eltanexor oral DC16VO6 AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
CHS-828 + Eltanexor oral DCMBERR CHS-828 Ewing sarcoma (Cell Line: TC-71) [2]
Cytarabine + Eltanexor oral DCU5HC9 Cytarabine Ewing sarcoma (Cell Line: TC-71) [2]
Eltanexor oral + Carfilzomib DCX74SZ Carfilzomib Ewing sarcoma (Cell Line: TC-71) [2]
Eltanexor oral + Artemether DCYHXLX Artemether Ewing sarcoma (Cell Line: TC-71) [2]
Eltanexor oral + Panobinostat DCUG54T Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Eltanexor oral + Doxycycline DCWVW5C Doxycycline DD2 (Cell Line: DD2) [2]
Eltanexor oral + GDC-0084 DCJ0YIF GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
Eltanexor oral + Marizomib DCCDAP6 Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Eltanexor oral + Mitotane DC8N5Z3 Mitotane Ewing sarcoma (Cell Line: TC-71) [2]
Eltanexor oral + Atovaquone DCNZGH8 Atovaquone DD2 (Cell Line: DD2) [2]
Eltanexor oral + Sitosterol DCD4WJJ Sitosterol Hepatoblastoma (Cell Line: HB3) [3]
Eltanexor oral + Clindamycin DCB5PUV Clindamycin Hepatoblastoma (Cell Line: HB3) [3]
Eltanexor oral + Ruxolitinib DCBH1FM Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Eltanexor oral + Lumefantrine DCBX9W2 Lumefantrine Hepatoblastoma (Cell Line: HB3) [3]
Eltanexor oral + NITD609 DC1YDZ8 NITD609 Hepatoblastoma (Cell Line: HB3) [3]
Eltanexor oral + Chloroquine DCBH4UN Chloroquine Hepatoblastoma (Cell Line: HB3) [3]
Eltanexor oral + Naltrexone DCS3051 Naltrexone Hepatoblastoma (Cell Line: HB3) [3]
Eltanexor oral + Atovaquone DCWYE90 Atovaquone Hepatoblastoma (Cell Line: HB3) [3]
Epothilone D + Eltanexor oral DCGY2GD Epothilone D Ewing sarcoma (Cell Line: TC-71) [2]
Everolimus + Eltanexor oral DCWQAKD Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Eltanexor oral DCBX6KH Exherin Ewing sarcoma (Cell Line: TC-71) [2]
GDC-0084 + Eltanexor oral DCGCS6W GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + Eltanexor oral DCKOQVR JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
LY2874455 + Eltanexor oral DC4QZ5J LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
Methotrexate + Eltanexor oral DCQG38B Methotrexate Ewing sarcoma (Cell Line: TC-71) [2]
Methotrexate + Eltanexor oral DCE9PQP Methotrexate Hodgkin lymphoma (Cell Line: U-HO1) [2]
Mitomycin + Eltanexor oral DCASEI1 Mitomycin Ewing sarcoma (Cell Line: TC-71) [2]
Mitomycin + Eltanexor oral DCD8U8A Mitomycin Hodgkin lymphoma (Cell Line: U-HO1) [3]
NVP-AUY922 + Eltanexor oral DCY074L NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [2]
OSI-906 + Eltanexor oral DC018M0 OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
PF-562271 + Eltanexor oral DC1JE83 PF-562271 Hodgkin lymphoma (Cell Line: U-HO1) [2]
PHA-739358 + Eltanexor oral DCO5UR3 PHA-739358 Ewing sarcoma (Cell Line: TC-71) [2]
Tetrahydrouridine + Eltanexor oral DCL1ZPE Tetrahydrouridine Hodgkin lymphoma (Cell Line: U-HO1) [3]
THAPSIGARGIN + Eltanexor oral DCTV9J6 THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 37 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.