Details of the Drug Combinations

General Information of This Drug (ID: DM7MT6E)

• Drug Name: Prasugrel (DM7MT6E)
• Synonyms: Effient (TN)

Indication

Acute coronary syndrome; ICD 11: BA41; Status: Approved [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Prasugrel + Idarubicin	DCJ1L2W	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]

14 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Prasugrel + Bivalirudin	DC4EIYJ	Bivalirudin	Myocardial Infarction	[3]
Prasugrel + Brilinta	DCH6MMX	Brilinta	ST-Elevation Myocardial Infarction	[4]
Prasugrel + Clopidogrel	DCJ48H7	Clopidogrel	Acute Coronary Syndrome	[5]
Prasugrel + Aspirin	DCSAJI9	Aspirin	Coronary Artery Disease	[6]
Prasugrel + Cangrelor	DC56HU0	Cangrelor	Coronary Artery Disease	[7]
Prasugrel + Brilinta	DC7RF5D	Brilinta	Atrial Fibrillation	[8]
Prasugrel + Aspirin	DCL3O61	Aspirin	Coronary Artery Disease	[9]
Prasugrel + Clopidogrel	DCB552G	Clopidogrel	Coronary Artery Disease	[9]
Prasugrel + Vorapaxar	DCASBPE	Vorapaxar	Myocardial Infarction	[10]
Prasugrel + Brilinta	DC3EC39	Brilinta	Cardiovascular Diseases	[11]
Prasugrel + Vorapaxar	DC97619	Vorapaxar	Myocardial Infarction	[10]
Prasugrel + Brilinta	DCKXNMR	Brilinta	Myocardial Infarction	[10]
Prasugrel + Brilinta	DC963XW	Brilinta	Coronary Artery Disease	[12]
Prasugrel + Aspirin	DCOQV2Q	Aspirin	Coronary Artery Disease	[13]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7562).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] ClinicalTrials.gov (NCT00976092) Efficacy Study of Combined Prasugrel and Bivalirudin Versus Clopidogrel and Heparin in Myocardial Infarction
• [4] ClinicalTrials.gov (NCT01531114) PraSugrel vs TicagrElor in ST-Elevation Myocardial Infarction paTients With Diabetes Mellitus
• [5] ClinicalTrials.gov (NCT01115738) Clopidogrel to Prasugrel in Acute Coronary Syndrome (ACS) Patients
• [6] ClinicalTrials.gov (NCT01589978) PROMUS Element Plus US Post-Approval Study
• [7] ClinicalTrials.gov (NCT01852019) Cangrelor Prasugrel Transition Study
• [8] ClinicalTrials.gov (NCT02866175) Edoxaban Treatment Versus Vitamin K Antagonist in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention
• [9] ClinicalTrials.gov (NCT01598337) The Effect Of Antiplatelets Therapy On Saphenous Vein Coronary Artery Bypass Graft Patency
• [10] ClinicalTrials.gov (NCT02545933) Vorapaxar in Patients With Prior Myocardial Infarction Treated With Prasugrel and Ticagrelor
• [11] ClinicalTrials.gov (NCT02587260) Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function in Humans (HI-TECH)
• [12] ClinicalTrials.gov (NCT01957540) Differential Effect of Ticagrelor Versus Prasugrel Maintenance Dose on Endothelial Function of Peripheral Vessels in Patients With Coronary Artery Disease
• [13] ClinicalTrials.gov (NCT04006288) Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease