Details of the Drug Combination

General Information of Drug Combination (ID: DCOQV2Q)

Drug Combination Name
Prasugrel Aspirin
Indication
Disease Entry Status REF
Coronary Artery Disease Phase 4 [1]
Component Drugs Prasugrel   DM7MT6E Aspirin   DM672AH
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Prasugrel
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [2]
Prasugrel Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
P2Y purinoceptor 12 (P2RY12) TTZ1DT0 P2Y12_HUMAN Inhibitor [7]
------------------------------------------------------------------------------------
Prasugrel Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [8]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [8]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [8]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [8]
------------------------------------------------------------------------------------
Indication(s) of Aspirin
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [3]
Adenomatous colon polyp N.A. Approved [3]
Back pain ME84.Z Approved [3]
Common cold CA00 Approved [3]
Headache 8A80-8A84 Approved [3]
Migraine disorder N.A. Approved [3]
Myocardial infarction BA41-BA43 Approved [4]
Osteoarthritis FA00-FA05 Approved [3]
Pain MG30-MG3Z Approved [5]
Cardiovascular disease BA00-BE2Z Phase 3 [5]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2/3 [6]
Colon cancer 2B90.Z Investigative [3]
Aspirin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Prostaglandin G/H synthase (COX) TTK0943 PGH1_HUMAN; PGH2_HUMAN Inhibitor [21]
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [4]
------------------------------------------------------------------------------------
Aspirin Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [22]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [23]
Sodium-dependent phosphate transport protein 1 (SLC17A1) DT8ARWJ NPT1_HUMAN Substrate [24]
Probable small intestine urate exporter (SLC17A4) DTHE530 S17A4_HUMAN Substrate [25]
------------------------------------------------------------------------------------
Aspirin Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [26]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Metabolism [27]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [28]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [29]
N-acetyltransferase 2 (NAT2) DER7TA0 ARY2_HUMAN Metabolism [28]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DESD26P UD16_HUMAN Metabolism [28]
------------------------------------------------------------------------------------
⏷ Show the Full List of 6 DME(s)
Aspirin Interacts with 513 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Affects Response To Substance [28]
Arylamine N-acetyltransferase 2 (NAT2) OTBPDQOY ARY2_HUMAN Affects Response To Substance [30]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [31]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [32]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Increases ADR [33]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Increases ADR [33]
Leukotriene C4 synthase (LTC4S) OT3XNFJZ LTC4S_HUMAN Affects Response To Substance [34]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases ADR [35]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Decreases Response To Substance [36]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [37]
Integrin alpha-IIb (ITGA2B) OT4Y17PY ITA2B_HUMAN Decreases Expression [38]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Increases ADR [39]
Testis-expressed basic protein 1 (TSBP1) OT5GE8IO TSBP1_HUMAN Increases ADR [40]
Thromboxane A2 receptor (TBXA2R) OT9CIHQ5 TA2R_HUMAN Decreases Response To Substance [41]
HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1) OTC6GISG DQA1_HUMAN Increases ADR [40]
Collagen alpha-1(XXVI) chain (COL26A1) OTMS7RNF COQA1_HUMAN Affects Response To Substance [42]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Increases ADR [43]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases ADR [18]
Laminin subunit alpha-1 (LAMA1) OTQZMP86 LAMA1_HUMAN Increases ADR [44]
HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5) OTUX5TWM DRB5_HUMAN Increases ADR [40]
Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3) OTBQRU82 GAL3B_HUMAN Increases Expression [9]
Anoctamin-9 (ANO9) OTQ2UM3M ANO9_HUMAN Increases Expression [9]
PH and SEC7 domain-containing protein 1 (PSD) OTUZIXUZ PSD1_HUMAN Increases Expression [9]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) OTFBU4GD P3C2A_HUMAN Decreases Expression [9]
Protocadherin-17 (PCDH17) OTRK0M05 PCD17_HUMAN Increases Expression [9]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Increases Expression [9]
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) OT4AVU95 MYPT1_HUMAN Decreases Expression [9]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Increases Expression [9]
Origin recognition complex subunit 4 (ORC4) OT3ACTST ORC4_HUMAN Increases Expression [9]
85/88 kDa calcium-independent phospholipase A2 (PLA2G6) OT5FL0WU PLPL9_HUMAN Increases Expression [9]
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) OTSQGLSB TI17B_HUMAN Increases Expression [9]
Bromodomain-containing protein 4 (BRD4) OT2Y2TCW BRD4_HUMAN Increases Expression [9]
Astrotactin-2 (ASTN2) OTF0W2FJ ASTN2_HUMAN Increases Expression [9]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Increases Expression [9]
Sperm-associated antigen 6 (SPAG6) OTVVG3Q0 SPAG6_HUMAN Increases Expression [9]
Trafficking protein particle complex subunit 6A (TRAPPC6A) OT0ZRV5C TPC6A_HUMAN Increases Expression [9]
DNA topoisomerase 3-beta-1 (TOP3B) OTNFEUOO TOP3B_HUMAN Increases Expression [9]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [9]
Salivary acidic proline-rich phosphoprotein 1/2 (PRH1) OTQZ6HX0 PRPC_HUMAN Decreases Expression [9]
Ribonuclease pancreatic (RNASE1) OTKZ7CO9 RNAS1_HUMAN Increases Expression [9]
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Increases Expression [9]
Ras-related protein Ral-B (RALB) OTFH203X RALB_HUMAN Decreases Expression [9]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [9]
Atrial natriuretic peptide receptor 1 (NPR1) OTRWART5 ANPRA_HUMAN Decreases Expression [9]
Troponin I, cardiac muscle (TNNI3) OT65E12V TNNI3_HUMAN Increases Expression [9]
L-serine dehydratase/L-threonine deaminase (SDS) OT5WTJ2M SDHL_HUMAN Increases Expression [9]
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) OTHJQ1DZ RPB1_HUMAN Increases Expression [9]
DNA excision repair protein ERCC-5 (ERCC5) OTQAKFJM ERCC5_HUMAN Increases Expression [9]
Neuroendocrine convertase 1 (PCSK1) OTPBRJ54 NEC1_HUMAN Decreases Expression [9]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Increases Expression [9]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) OTBDF9HJ ODO2_HUMAN Decreases Expression [9]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Expression [9]
Protein phosphatase inhibitor 2 (PPP1R2) OTNLOUQR IPP2_HUMAN Decreases Expression [9]
Isoleucine--tRNA ligase, cytoplasmic (IARS1) OT9WXH5N SYIC_HUMAN Decreases Expression [9]
Transcription initiation factor TFIID subunit 6 (TAF6) OTY1Z9C4 TAF6_HUMAN Decreases Expression [9]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Decreases Expression [9]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Increases Expression [9]
Rho-related GTP-binding protein RhoN (RND2) OT98M6UI RND2_HUMAN Increases Expression [9]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (NDST2) OT21PY3J NDST2_HUMAN Increases Expression [9]
Monocarboxylate transporter 1 (SLC16A1) OTW1UTZ7 MOT1_HUMAN Decreases Expression [9]
Puromycin-sensitive aminopeptidase (NPEPPS) OTMENFXR PSA_HUMAN Decreases Expression [9]
Small ubiquitin-related modifier 3 (SUMO3) OTTUJQJ1 SUMO3_HUMAN Increases Expression [9]
Actin-related protein 3 (ACTR3) OT05LJSH ARP3_HUMAN Decreases Expression [9]
26S proteasome regulatory subunit 10B (PSMC6) OTG8997V PRS10_HUMAN Decreases Expression [9]
AP-2 complex subunit beta (AP2B1) OTL6LZJ4 AP2B1_HUMAN Decreases Expression [9]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Decreases Expression [9]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Decreases Expression [9]
Pituitary homeobox 1 (PITX1) OTA0UN4C PITX1_HUMAN Increases Expression [9]
General transcription factor II-I (GTF2I) OTUYL1TQ GTF2I_HUMAN Decreases Expression [9]
Cyclin-dependent kinase 3 (CDK3) OT2GP6RL CDK3_HUMAN Increases Expression [9]
Early growth response protein 4 (EGR4) OT4R3ECK EGR4_HUMAN Decreases Expression [9]
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) OT6OCR3H CCG1_HUMAN Decreases Expression [9]
Sodium channel subunit beta-1 (SCN1B) OTGD78J3 SCN1B_HUMAN Increases Expression [9]
V-type proton ATPase 116 kDa subunit a 3 (TCIRG1) OTU1AIEW VPP3_HUMAN Increases Expression [9]
Phosphatidylinositol-binding clathrin assembly protein (PICALM) OTQVRPMQ PICAL_HUMAN Decreases Expression [9]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) OT25JBA3 F263_HUMAN Decreases Expression [9]
TBC1 domain family member 10B (TBC1D10B) OT5MVCI5 TB10B_HUMAN Increases Expression [9]
Cyclin-J (CCNJ) OTCR4WVV CCNJ_HUMAN Increases Expression [9]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Increases Expression [9]
DENN domain-containing protein 5A (DENND5A) OT0QNNY1 DEN5A_HUMAN Increases Expression [9]
Kinesin-like protein KIF21A (KIF21A) OT511XD9 KI21A_HUMAN Increases Expression [9]
Calcium-activated potassium channel subunit beta-4 (KCNMB4) OTYQG46B KCMB4_HUMAN Decreases Expression [9]
EF-hand calcium-binding domain-containing protein 4A (CRACR2B) OT8L843R EFC4A_HUMAN Increases Expression [9]
Tumor protein p53-inducible protein 13 (TP53I13) OTSUH9V8 P5I13_HUMAN Increases Expression [9]
Basal body-orientation factor 1 (BBOF1) OT88DXU7 BBOF1_HUMAN Increases Expression [9]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Increases Expression [9]
Transient receptor potential cation channel subfamily M member 4 (TRPM4) OT354X8E TRPM4_HUMAN Increases Expression [9]
Protocadherin Fat 3 (FAT3) OT3C6H8W FAT3_HUMAN Increases Expression [9]
Sec1 family domain-containing protein 2 (SCFD2) OTYM55ET SCFD2_HUMAN Increases Expression [9]
Calcyphosin-like protein (CAPSL) OT5RRQ8E CAPSL_HUMAN Increases Expression [9]
Selenoprotein M (SELENOM) OTJ7PORS SELM_HUMAN Increases Expression [9]
Geranylgeranyl transferase type-2 subunit alpha (RABGGTA) OTYMG99C PGTA_HUMAN Increases Expression [9]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Increases Expression [9]
Ribonuclease K6 (RNASE6) OTJIK1RY RNAS6_HUMAN Increases Expression [9]
CAP-Gly domain-containing linker protein 3 (CLIP3) OTGJEGIB CLIP3_HUMAN Increases Expression [9]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Increases Expression [9]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Increases Expression [9]
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 (ACAP3) OTOE9OYV ACAP3_HUMAN Increases Expression [9]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [9]
Translin-associated protein X (TSNAX) OTZ9SGWB TSNAX_HUMAN Increases Expression [9]
C-C motif chemokine 19 (CCL19) OTQ2UJMH CCL19_HUMAN Increases Expression [9]
Copine-1 (CPNE1) OTH5YKSL CPNE1_HUMAN Increases Expression [9]
Allograft inflammatory factor 1-like (AIF1L) OTDEOB80 AIF1L_HUMAN Increases Expression [9]
Glucose-6-phosphatase 3 (G6PC3) OTH7BWNL G6PC3_HUMAN Increases Expression [9]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Increases Expression [9]
Transmembrane emp24 domain-containing protein 9 (TMED9) OTYGAQS0 TMED9_HUMAN Increases Expression [9]
Intraflagellar transport protein 27 homolog (IFT27) OT3NY6O6 IFT27_HUMAN Increases Expression [9]
Cyclin-dependent kinase 19 (CDK19) OTVMM0CP CDK19_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase RNF26 (RNF26) OTPXA60S RNF26_HUMAN Increases Expression [9]
tRNA dimethylallyltransferase (TRIT1) OTCU9FS5 MOD5_HUMAN Increases Expression [9]
T-lymphocyte surface antigen Ly-9 (LY9) OT1PKGDI LY9_HUMAN Increases Expression [9]
Striatin-4 (STRN4) OTHK2ZN6 STRN4_HUMAN Increases Expression [9]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [9]
ATP-dependent RNA helicase DDX18 (DDX18) OTKB9C3S DDX18_HUMAN Decreases Expression [9]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Decreases Expression [9]
Programmed cell death 1 ligand 1 (CD274) OTJ0VFDL PD1L1_HUMAN Increases Expression [9]
Tropomodulin-4 (TMOD4) OTXLGJ4R TMOD4_HUMAN Increases Expression [9]
SUN domain-containing protein 2 (SUN2) OT2IQJUC SUN2_HUMAN Increases Expression [9]
TNF receptor-associated factor 6 (TRAF6) OTA5GO5K TRAF6_HUMAN Increases Expression [9]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [31]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [31]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [31]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Degradation [45]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases Phosphorylation [45]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Increases Expression [37]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [37]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [37]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Decreases Expression [37]
Ornithine decarboxylase (ODC1) OTNDAGRR DCOR_HUMAN Increases Expression [37]
Ezrin (EZR) OTHBPF1Z EZRI_HUMAN Decreases Expression [37]
Integrin beta-4 (ITGB4) OT28UK84 ITB4_HUMAN Decreases Expression [37]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [37]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Decreases Expression [37]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [37]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Decreases Expression [37]
Prohibitin 1 (PHB1) OTZNXYS2 PHB1_HUMAN Decreases Expression [37]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [37]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [37]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Increases Expression [37]
Small ribosomal subunit protein uS9 (RPS16) OTVGZOB5 RS16_HUMAN Increases Expression [37]
Ras-related C3 botulinum toxin substrate 1 (RAC1) OTKRO61U RAC1_HUMAN Increases Expression [37]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Increases Expression [37]
Glutathione S-transferase omega-1 (GSTO1) OTUJ93MN GSTO1_HUMAN Decreases Expression [37]
Bleomycin hydrolase (BLMH) OT2QPWQJ BLMH_HUMAN Decreases Expression [37]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Increases Expression [37]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [37]
Charged multivesicular body protein 1a (CHMP1A) OTVQ5UWX CHM1A_HUMAN Decreases Expression [37]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) OTB3BFCV HNRDL_HUMAN Decreases Expression [10]
Nucleoside diphosphate kinase 6 (NME6) OTJNKOFA NDK6_HUMAN Increases Expression [10]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Expression [10]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Decreases Expression [10]
Cystatin-A (CSTA) OT1K68KE CYTA_HUMAN Increases Expression [10]
Collagen alpha-1(III) chain (COL3A1) OTT1EMLM CO3A1_HUMAN Decreases Expression [10]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [10]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [10]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Increases Expression [10]
Platelet endothelial cell adhesion molecule (PECAM1) OTXOM4D9 PECA1_HUMAN Decreases Expression [10]
Tyrosine-protein kinase Fer (FER) OT9JR7AE FER_HUMAN Decreases Expression [10]
Pulmonary surfactant-associated protein D (SFTPD) OTNKPDJC SFTPD_HUMAN Increases Expression [10]
Small ribosomal subunit protein eS19 (RPS19) OTBKGP48 RS19_HUMAN Increases Expression [10]
Cell surface glycoprotein MUC18 (MCAM) OTT8XKGE MUC18_HUMAN Increases Expression [10]
RNA-binding protein FXR2 (FXR2) OTQX7ATF FXR2_HUMAN Decreases Expression [10]
Ras-related protein Rab-2A (RAB2A) OT6SK83U RAB2A_HUMAN Increases Expression [10]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Increases Expression [10]
Hemoglobin subunit gamma-2 (HBG2) OT4J48JJ HBG2_HUMAN Increases Expression [10]
Butyrophilin subfamily 3 member A2 (BTN3A2) OT3DIBU3 BT3A2_HUMAN Decreases Expression [10]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Decreases Expression [10]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Increases Expression [10]
Histone deacetylase 1 (HDAC1) OTQDNOXZ HDAC1_HUMAN Increases Expression [10]
Ras GTPase-activating-like protein IQGAP2 (IQGAP2) OTX2UA7P IQGA2_HUMAN Increases Expression [10]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Decreases Expression [10]
MOB kinase activator 2 (MOB2) OTMBE0NS MOB2_HUMAN Increases Expression [10]
Centromere protein S (CENPS) OTZ4J391 CENPS_HUMAN Increases Expression [10]
LIM domain only protein 7 (LMO7) OTDLY6TC LMO7_HUMAN Increases Expression [10]
Neuronal cell adhesion molecule (NRCAM) OT80HHQ2 NRCAM_HUMAN Decreases Expression [10]
N-alpha-acetyltransferase 38, NatC auxiliary subunit (NAA38) OTI8VWK3 LSMD1_HUMAN Increases Expression [10]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Decreases Expression [10]
Translocon-associated protein subunit gamma (SSR3) OTJQP0IZ SSRG_HUMAN Increases Expression [10]
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) OTYOTM2B NUBP2_HUMAN Decreases Expression [10]
Pseudouridylate synthase 1 homolog (PUS1) OTS2DQ0N PUS1_HUMAN Increases Expression [10]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [11]
Importin subunit alpha-4 (KPNA3) OTLI3TM2 IMA4_HUMAN Increases Expression [11]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [11]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [11]
E3 ubiquitin-protein ligase SIAH2 (SIAH2) OTKED2XN SIAH2_HUMAN Decreases Expression [11]
Tumor protein D54 (TPD52L2) OTTOG0NK TPD54_HUMAN Decreases Expression [11]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [11]
GDNF family receptor alpha-3 (GFRA3) OT07XAZF GFRA3_HUMAN Increases Expression [11]
Tetraspanin-3 (TSPAN3) OT7WS6ZI TSN3_HUMAN Decreases Expression [11]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Decreases Expression [11]
Breast cancer anti-estrogen resistance protein 3 (BCAR3) OTPJ17M8 BCAR3_HUMAN Increases Expression [11]
PRA1 family protein 3 (ARL6IP5) OTYZ6BEQ PRAF3_HUMAN Increases Expression [11]
Gamma-aminobutyric acid receptor-associated protein (GABARAP) OTAQUX6E GBRAP_HUMAN Decreases Expression [11]
Histone acetyltransferase KAT7 (KAT7) OTUN98IC KAT7_HUMAN Decreases Expression [11]
STAM-binding protein (STAMBP) OTOT2OXM STABP_HUMAN Increases Expression [11]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Decreases Expression [11]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Expression [11]
T-cell surface glycoprotein CD8 alpha chain (CD8A) OTDWQJXK CD8A_HUMAN Decreases Expression [11]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Decreases Expression [11]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [11]
HLA class II histocompatibility antigen gamma chain (CD74) OTO16X4Q HG2A_HUMAN Decreases Expression [11]
Argininosuccinate lyase (ASL) OTI2NGQR ARLY_HUMAN Decreases Expression [11]
Calpain small subunit 1 (CAPNS1) OT95EBBD CPNS1_HUMAN Decreases Expression [11]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) OTEG4KU9 RPN1_HUMAN Decreases Expression [11]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Decreases Expression [11]
Profilin-1 (PFN1) OTHTGA1H PROF1_HUMAN Decreases Expression [11]
Adenine phosphoribosyltransferase (APRT) OT5ZUKVF APT_HUMAN Decreases Expression [11]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Expression [11]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [11]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Expression [11]
Integrin alpha-5 (ITGA5) OT3RCI67 ITA5_HUMAN Decreases Expression [11]
Tyrosine-protein kinase Fgr (FGR) OTCUYU9F FGR_HUMAN Decreases Expression [11]
Furin (FURIN) OTM2665Z FURIN_HUMAN Decreases Expression [11]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [11]
Interferon regulatory factor 1 (IRF1) OT43DI6J IRF1_HUMAN Increases Expression [11]
Cation-independent mannose-6-phosphate receptor (IGF2R) OTDXPQVX MPRI_HUMAN Increases Expression [11]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Decreases Expression [11]
Hematopoietic lineage cell-specific protein (HCLS1) OTX7WGYN HCLS1_HUMAN Decreases Expression [11]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [11]
Interleukin-2 receptor subunit beta (IL2RB) OT6M0F70 IL2RB_HUMAN Increases Expression [11]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Decreases Expression [11]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Decreases Expression [11]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [11]
Calpain-2 catalytic subunit (CAPN2) OTIAPE5J CAN2_HUMAN Increases Expression [11]
Probable ATP-dependent RNA helicase DDX5 (DDX5) OTLS124U DDX5_HUMAN Increases Expression [11]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Decreases Expression [11]
E3 ubiquitin-protein ligase TRIM21 (TRIM21) OTA4UJCF RO52_HUMAN Decreases Expression [11]
Transcription factor E3 (TFE3) OTM99ZWH TFE3_HUMAN Decreases Expression [11]
Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) OTXF0B09 IF2B_HUMAN Increases Expression [11]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [11]
fMet-Leu-Phe receptor (FPR1) OTFF9I6W FPR1_HUMAN Decreases Expression [11]
Granulysin (GNLY) OTZJKA8C GNLY_HUMAN Decreases Expression [11]
Peptidyl-prolyl cis-trans isomerase B (PPIB) OTLPH6KN PPIB_HUMAN Decreases Expression [11]
Calnexin (CANX) OTYP1F6J CALX_HUMAN Decreases Expression [11]
T-cell differentiation antigen CD6 (CD6) OTOS044E CD6_HUMAN Decreases Expression [11]
High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) OTBZBL9Y FCERG_HUMAN Decreases Expression [11]
Syndecan-4 (SDC4) OTKUVUGZ SDC4_HUMAN Decreases Expression [11]
Cytokine receptor common subunit gamma (IL2RG) OTRZ3OMY IL2RG_HUMAN Decreases Expression [11]
Protein S100-A11 (S100A11) OTI57KDN S10AB_HUMAN Decreases Expression [11]
Intercellular adhesion molecule 3 (ICAM3) OTTZ5A5D ICAM3_HUMAN Decreases Expression [11]
Protein EVI2B (EVI2B) OT98X1OE EVI2B_HUMAN Increases Expression [11]
Protein DEK (DEK) OTYCJ5H6 DEK_HUMAN Increases Expression [11]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Expression [11]
F-actin-capping protein subunit alpha-2 (CAPZA2) OTHAO4V2 CAZA2_HUMAN Increases Expression [11]
Prolyl endopeptidase (PREP) OTSJZBB5 PPCE_HUMAN Decreases Expression [11]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Decreases Expression [11]
Large ribosomal subunit protein eL34 (RPL34) OT0U9VMQ RL34_HUMAN Increases Expression [11]
Dual specificity protein kinase CLK2 (CLK2) OT1CRSY2 CLK2_HUMAN Decreases Expression [11]
Dual specificity protein kinase CLK3 (CLK3) OT74DJ3J CLK3_HUMAN Decreases Expression [11]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Decreases Expression [11]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Decreases Expression [11]
Hepatoma-derived growth factor (HDGF) OT16PTBC HDGF_HUMAN Decreases Expression [11]
F-actin-capping protein subunit alpha-1 (CAPZA1) OTAXA66U CAZA1_HUMAN Increases Expression [11]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Decreases Expression [11]
Protein SEC13 homolog (SEC13) OTSR4WWM SEC13_HUMAN Decreases Expression [11]
cAMP-regulated phosphoprotein 19 (ARPP19) OTZS3IT6 ARP19_HUMAN Increases Expression [11]
ATP synthase subunit epsilon, mitochondrial (ATP5F1E) OTMPLAIS ATP5E_HUMAN Increases Expression [11]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Increases Expression [11]
Serine/threonine-protein phosphatase 4 catalytic subunit (PPP4C) OT4B0TNV PP4C_HUMAN Decreases Expression [11]
V-type proton ATPase subunit d 1 (ATP6V0D1) OT9GU2NW VA0D1_HUMAN Decreases Expression [11]
Protein BTG1 (BTG1) OTVJ2CDM BTG1_HUMAN Increases Expression [11]
Thymosin beta-4 (TMSB4X) OT9HPLP3 TYB4_HUMAN Increases Expression [11]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [11]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) OTIIGGZ2 RS27A_HUMAN Increases Expression [11]
Transformer-2 protein homolog beta (TRA2B) OTZYQW52 TRA2B_HUMAN Increases Expression [11]
Rho-related GTP-binding protein RhoG (RHOG) OTJ7J1WA RHOG_HUMAN Decreases Expression [11]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) OTLQN1E2 HNRPU_HUMAN Increases Expression [11]
Interferon regulatory factor 9 (IRF9) OTK4MYQJ IRF9_HUMAN Decreases Expression [11]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Expression [11]
Killer cell lectin-like receptor subfamily B member 1 (KLRB1) OTQ2959Y KLRB1_HUMAN Increases Expression [11]
Protein flightless-1 homolog (FLII) OT7G9JG6 FLII_HUMAN Decreases Expression [11]
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) OT6T408U MP2K5_HUMAN Decreases Expression [11]
Integrin-linked protein kinase (ILK) OTYG2FD1 ILK_HUMAN Decreases Expression [11]
Peptidyl-prolyl cis-trans isomerase G (PPIG) OTZ8BTTM PPIG_HUMAN Increases Expression [11]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [11]
Flotillin-2 (FLOT2) OTZ0QR5L FLOT2_HUMAN Decreases Expression [11]
Protein tyrosine phosphatase receptor type C-associated protein (PTPRCAP) OT2YERNV PTCA_HUMAN Decreases Expression [11]
Poly(rC)-binding protein 1 (PCBP1) OTHN0TD7 PCBP1_HUMAN Decreases Expression [11]
Homeobox protein TGIF1 (TGIF1) OTN9VHAG TGIF1_HUMAN Decreases Expression [11]
Myeloid leukemia factor 2 (MLF2) OTU3B4WU MLF2_HUMAN Decreases Expression [11]
Hsp90 co-chaperone Cdc37 (CDC37) OTYDT4A7 CDC37_HUMAN Decreases Expression [11]
Proprotein convertase subtilisin/kexin type 7 (PCSK7) OTVR1K2Y PCSK7_HUMAN Decreases Expression [11]
Protein NKG7 (NKG7) OTXDD006 NKG7_HUMAN Decreases Expression [11]
MAP kinase-activated protein kinase 3 (MAPKAPK3) OT7IWJNI MAPK3_HUMAN Decreases Expression [11]
Guanylate kinase (GUK1) OTLI0HRU KGUA_HUMAN Decreases Expression [11]
All-trans retinoic acid-induced differentiation factor (ATRAID) OTOHZG1O ARAID_HUMAN Decreases Expression [11]
eIF5-mimic protein 2 (BZW1) OT4GUFIG 5MP2_HUMAN Increases Expression [11]
F-box only protein 11 (FBXO11) OTGWF3Q2 FBX11_HUMAN Increases Expression [11]
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2) OT1O2K47 LIRA2_HUMAN Decreases Expression [11]
Protein odd-skipped-related 1 (OSR1) OTB19LEQ OSR1_HUMAN Increases Expression [11]
Pumilio homolog 2 (PUM2) OT2H7NXV PUM2_HUMAN Increases Expression [11]
PEST proteolytic signal-containing nuclear protein (PCNP) OTJUQ122 PCNP_HUMAN Increases Expression [11]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Decreases Expression [11]
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1) OTS8G0EN BAP1_HUMAN Decreases Expression [11]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [11]
Protein TFG (TFG) OT2KJENI TFG_HUMAN Increases Expression [11]
Ninjurin-1 (NINJ1) OTLRZ1EU NINJ1_HUMAN Decreases Expression [11]
Erbin (ERBIN) OTNWTUA8 ERBIN_HUMAN Increases Expression [11]
Granulocyte colony-stimulating factor receptor (CSF3R) OTXRAY6X CSF3R_HUMAN Decreases Expression [11]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) OT8GTI1V VATO_HUMAN Decreases Expression [11]
ETS-related transcription factor Elf-4 (ELF4) OT167PR5 ELF4_HUMAN Decreases Expression [11]
Prohibitin-2 (PHB2) OTCAX3AW PHB2_HUMAN Decreases Expression [11]
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) OTJP4U7K HNRL1_HUMAN Decreases Expression [11]
Programmed cell death protein 10 (PDCD10) OTCHJTSF PDC10_HUMAN Increases Expression [11]
GTP-binding protein 2 (GTPBP2) OTOJ1KUA GTPB2_HUMAN Decreases Expression [11]
NF-kappa-B inhibitor zeta (NFKBIZ) OTU728KS IKBZ_HUMAN Increases Expression [11]
Large ribosomal subunit protein mL46 (MRPL46) OTMQ2A0Q RM46_HUMAN Increases Expression [11]
Growth hormone-inducible transmembrane protein (GHITM) OTBPNIC0 GHITM_HUMAN Increases Expression [11]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [11]
Mediator of RNA polymerase II transcription subunit 4 (MED4) OTALFN4S MED4_HUMAN Increases Expression [11]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Decreases Expression [11]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1) OTFOJUIQ PHAG1_HUMAN Increases Expression [11]
Phosphatidylinositol 4-kinase beta (PI4KB) OTI9UQSU PI4KB_HUMAN Decreases Expression [11]
Peflin (PEF1) OTY24CUW PEF1_HUMAN Decreases Expression [11]
Lysine-specific demethylase 5B (KDM5B) OT5DL94T KDM5B_HUMAN Decreases Expression [11]
Tyrosine-protein kinase BAZ1B (BAZ1B) OTD5KR2J BAZ1B_HUMAN Decreases Expression [11]
F-box/LRR-repeat protein 3 (FBXL3) OTDQ1QKV FBXL3_HUMAN Increases Expression [11]
Apoptotic chromatin condensation inducer in the nucleus (ACIN1) OTK81F92 ACINU_HUMAN Decreases Expression [11]
Transforming acidic coiled-coil-containing protein 3 (TACC3) OTRNEZTA TACC3_HUMAN Decreases Expression [11]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Increases Expression [46]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [47]
Nitric oxide synthase, inducible (NOS2) OTKKIOJ1 NOS2_HUMAN Increases Expression [48]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Increases Expression [49]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Increases Expression [49]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Expression [49]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Activity [50]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Decreases Activity [50]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Decreases Activity [50]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Activity [51]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [52]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [53]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Increases Expression [53]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [53]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Activity [54]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [55]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [56]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Increases Expression [32]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Increases Expression [32]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [53]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [57]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [58]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Expression [53]
Ornithine transcarbamylase, mitochondrial (OTC) OTJ57GGA OTC_HUMAN Decreases Expression [59]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Cleavage [60]
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Activity [61]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Affects Activity [62]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Increases Expression [63]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [53]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Decreases Expression [64]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [55]
Fibrinogen alpha chain (FGA) OTMIHY80 FIBA_HUMAN Decreases Secretion [65]
Fibrinogen beta chain (FGB) OT6RKLI9 FIBB_HUMAN Decreases Secretion [65]
Albumin (ALB) OTVMM513 ALBU_HUMAN Decreases Secretion [65]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [53]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [66]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Acetylation [67]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [68]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [15]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [69]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Affects Expression [70]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [71]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [72]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [73]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Secretion [63]
Apolipoprotein(a) (LPA) OTRZLU9F APOA_HUMAN Decreases Expression [74]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Increases Expression [55]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [75]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [76]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [54]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) OTA4P0FC ACADM_HUMAN Increases Expression [77]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Activity [78]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [53]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [53]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Affects Methylation [79]
Xaa-Pro dipeptidase (PEPD) OT3LFY7S PEPD_HUMAN Increases Activity [80]
Glial fibrillary acidic protein (GFAP) OTQ01ZAS GFAP_HUMAN Decreases Expression [81]
L-selectin (SELL) OT6RAJZR LYAM1_HUMAN Decreases Expression [82]
Sucrase-isomaltase, intestinal (SI) OTUP724T SUIS_HUMAN Increases Activity [64]
Protein C-ets-2 (ETS2) OTPVHOZ7 ETS2_HUMAN Decreases Expression [53]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Decreases Expression [83]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Decreases Activity [84]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Decreases Expression [85]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [86]
P-selectin (SELP) OTWR90PK LYAM3_HUMAN Decreases Expression [87]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Decreases Expression [87]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [53]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Increases Expression [55]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [88]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [12]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [53]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [53]
N-formyl peptide receptor 2 (FPR2) OTEZ2THZ FPR2_HUMAN Increases Expression [89]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Decreases Expression [87]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [53]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [53]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Decreases Expression [53]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Expression [90]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) OT5BZ1J9 P85A_HUMAN Decreases Expression [53]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Expression [90]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [87]
M-phase inducer phosphatase 1 (CDC25A) OTSLKKCO MPIP1_HUMAN Decreases Expression [53]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Expression [53]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Increases Expression [32]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Localization [85]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [91]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [52]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [53]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [53]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Decreases Expression [15]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [92]
CD151 antigen (CD151) OTF3UZS7 CD151_HUMAN Decreases Expression [38]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Activity [93]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Increases Expression [77]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [94]
C-C chemokine receptor type 3 (CCR3) OT6GBUFA CCR3_HUMAN Increases Expression [95]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Decreases Expression [12]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [96]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [92]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [97]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [86]
Dermcidin (DCD) OTV5PBGJ DCD_HUMAN Decreases Secretion [65]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [55]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [98]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Decreases Expression [53]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [53]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Increases Expression [53]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Affects Activity [99]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [100]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Increases Expression [101]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Localization [102]
Protein kinase C delta type (PRKCD) OTSEH90E KPCD_HUMAN Increases Cleavage [76]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [53]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [103]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [57]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Increases Expression [52]
Peroxisomal bifunctional enzyme (EHHADH) OTBAAHL5 ECHP_HUMAN Decreases Expression [96]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [55]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Expression [77]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Expression [77]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Expression [53]
Serine/threonine-protein kinase ATR (ATR) OTH0OP1J ATR_HUMAN Decreases Expression [12]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Expression [53]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [104]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Decreases Expression [58]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [53]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Increases Expression [53]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Increases Expression [57]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [57]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Decreases Expression [97]
Gastrokine-1 (GKN1) OT7ZYFQ9 GKN1_HUMAN Affects Expression [105]
Mammalian ependymin-related protein 1 (EPDR1) OT5JW5RB EPDR1_HUMAN Decreases Expression [53]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [55]
Cysteinyl leukotriene receptor 1 (CYSLTR1) OT904HBN CLTR1_HUMAN Increases Expression [106]
Kinesin-like protein KIF3A (KIF3A) OTMUBSSK KIF3A_HUMAN Increases Expression [107]
Angiopoietin-related protein 3 (ANGPTL3) OTCD5Z9W ANGL3_HUMAN Decreases Expression [96]
Interleukin-1 receptor type 2 (IL1R2) OT0G7E35 IL1R2_HUMAN Affects Response To Substance [108]
Prostaglandin E2 receptor EP2 subtype (PTGER2) OT1AUZAA PE2R2_HUMAN Affects Response To Substance [109]
Voltage-dependent calcium channel gamma-6 subunit (CACNG6) OT2PC1E1 CCG6_HUMAN Affects Response To Substance [110]
Glutamate receptor 3 (GRIA3) OT34CNBR GRIA3_HUMAN Increases ADR [111]
T-box transcription factor TBX21 (TBX21) OT3UK5KE TBX21_HUMAN Affects Response To Substance [112]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Affects Response To Substance [34]
Platelet glycoprotein VI (GP6) OT4IE8DV GPVI_HUMAN Decreases Response To Substance [113]
Platelet glycoprotein Ib alpha chain (GP1BA) OT62PSOB GP1BA_HUMAN Increases Response To Substance [114]
Toll-like receptor 3 (TLR3) OT8QPYXZ TLR3_HUMAN Affects Response To Substance [115]
Indoleamine 2,3-dioxygenase 1 (IDO1) OT91DBN7 I23O1_HUMAN Affects Response To Substance [108]
Histamine N-methyltransferase (HNMT) OT9F303M HNMT_HUMAN Affects Response To Substance [34]
Pikachurin (EGFLAM) OTACZZJ0 EGFLA_HUMAN Increases ADR [44]
Regulator of G-protein signaling 7-binding protein (RGS7BP) OTAGSWMH R7BP_HUMAN Affects Response To Substance [116]
Thromboxane-A synthase (TBXAS1) OTAXZJJ4 THAS_HUMAN Affects Response To Substance [117]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Affects Response To Substance [118]
Serine/threonine-protein kinase 10 (STK10) OTC33Y2F STK10_HUMAN Affects Response To Substance [119]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Hydrolysis [120]
Prostaglandin D2 receptor 2 (PTGDR2) OTCSMVF1 PD2R2_HUMAN Affects Response To Substance [34]
Angiotensin-converting enzyme (ACE) OTDF1964 ACE_HUMAN Affects Response To Substance [121]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Affects Response To Substance [122]
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Affects Response To Substance [123]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Decreases Metabolism [124]
Bis(5'-adenosyl)-triphosphatase (FHIT) OTGWBSLA FHIT_HUMAN Increases ADR [44]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Response To Substance [113]
Adenosine receptor A3 (ADORA3) OTHO1BLK AA3R_HUMAN Affects Response To Substance [125]
Interleukin-13 (IL13) OTI4YS3Y IL13_HUMAN Affects Response To Substance [126]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Affects Response To Substance [127]
Leucine-rich melanocyte differentiation-associated protein (LRMDA) OTIPNKTU LRMDA_HUMAN Increases ADR [35]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Response To Substance [128]
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) OTIRUOHF FCERA_HUMAN Affects Response To Substance [34]
Sodium- and chloride-dependent betaine transporter (SLC6A12) OTKOR4F2 S6A12_HUMAN Affects Response To Substance [129]
High affinity immunoglobulin epsilon receptor subunit beta (MS4A2) OTMCAS2D FCERB_HUMAN Affects Response To Substance [130]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Affects Response To Substance [17]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases ADR [18]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Decreases Response To Substance [131]
Stromal membrane-associated protein 2 (SMAP2) OTPGVRKO SMAP2_HUMAN Affects Response To Substance [132]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Affects Response To Substance [133]
Prostaglandin E synthase 3 (PTGES3) OTPPQWI0 TEBP_HUMAN Increases ADR [18]
Glutamate receptor ionotropic, kainate 2 (GRIK2) OTQ41U3D GRIK2_HUMAN Increases ADR [111]
Inosine triphosphate pyrophosphatase (ITPA) OTQ47WVR ITPA_HUMAN Increases ADR [134]
Prostaglandin E2 receptor EP3 subtype (PTGER3) OTQODQUN PE2R3_HUMAN Affects Response To Substance [135]
P2Y purinoceptor 1 (P2RY1) OTR2KQ6Q P2RY1_HUMAN Decreases Response To Substance [136]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Affects Response To Substance [34]
Cysteinyl leukotriene receptor 2 (CYSLTR2) OTRNEOZ0 CLTR2_HUMAN Affects Response To Substance [34]
Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33) OTRZVI77 ADA33_HUMAN Affects Response To Substance [137]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [138]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Affects Response To Substance [139]
Lymphotoxin-alpha (LTA) OTUC3S76 TNFB_HUMAN Affects Response To Substance [140]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Affects Response To Substance [127]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases ADR [141]
Antigen peptide transporter 2 (TAP2) OTWSYFI7 TAP2_HUMAN Affects Response To Substance [142]
Prostacyclin receptor (PTGIR) OTWTABYM PI2R_HUMAN Affects Response To Substance [34]
Interleukin-17A (IL17A) OTY72FT2 IL17_HUMAN Affects Response To Substance [126]
Fibrous sheath-interacting protein 1 (FSIP1) OTYLL6GM FSIP1_HUMAN Affects Response To Substance [143]
Galectin-10 (CLC) OTYMYR85 LEG10_HUMAN Affects Response To Substance [144]
Centrosomal protein of 68 kDa (CEP68) OTZDM4J1 CEP68_HUMAN Affects Response To Substance [145]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Increases ADR [146]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Affects Response To Substance [147]
------------------------------------------------------------------------------------
⏷ Show the Full List of 513 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Coronary Artery Disease DCL3O61 N. A. Phase 3 [148]
Coronary Artery Disease DCSAJI9 N. A. Phase 1 [149]
------------------------------------------------------------------------------------

References

1 ClinicalTrials.gov (NCT04006288) Switching From DAPT to Dual Pathway Inhibition With Low-dose Rivaroxaban in Adjunct to Aspirin in Patients With Coronary Artery Disease
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7562).
3 Aspirin FDA Label
4 Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4139).
6 Protective Effect of Aspirin on COVID-19 Patients (PEAC)
7 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
8 The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012 Nov 12;72(16):2087-116.
9 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
10 Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
11 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
12 Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
13 Aspirin-sensitive rhinitis-associated changes in upper airway innervation. Eur Respir J. 2003 Dec;22(6):986-91. doi: 10.1183/09031936.03.00086002.
14 Nonsteroidal anti-inflammatory drugs induced endothelial apoptosis by perturbing peroxisome proliferator-activated receptor-delta transcriptional pathway. Mol Pharmacol. 2008 Nov;74(5):1399-406. doi: 10.1124/mol.108.049569. Epub 2008 Aug 4.
15 Aspirin induces apoptosis through the blockade of IL-6-STAT3 signaling pathway in human glioblastoma A172 cells. Biochem Biophys Res Commun. 2009 Sep 18;387(2):342-7. doi: 10.1016/j.bbrc.2009.07.022. Epub 2009 Jul 10.
16 Association analysis of UBE3C polymorphisms in Korean aspirin-intolerant asthmatic patients. Ann Allergy Asthma Immunol. 2010 Oct;105(4):307-312. doi: 10.1016/j.anai.2010.07.006.
17 Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. Cancer Epidemiol Biomarkers Prev. 2004 Apr;13(4):538-45.
18 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
19 VKORC1-1639 G>A Polymorphism and the Risk of Non-Variceal Upper Gastrointestinal Bleeding. J Gastrointestin Liver Dis. 2017 Mar;26(1):13-18. doi: 10.15403/jgld.2014.1121.261.vko.
20 Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. J Biol Chem. 2004 Jul 2;279(27):28320-9. doi: 10.1074/jbc.M401396200. Epub 2004 Apr 26.
21 Cyclooxygenase inhibitors: instrumental drugs to understand cardiovascular homeostasis and arterial thrombosis. Cardiovasc Hematol Disord Drug Targets. 2008 Dec;8(4):268-77.
22 Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22.
23 Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82.
24 Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter. J Biol Chem. 2010 Aug 20;285(34):26107-13.
25 A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an intestinal organic anion exporter. Am J Physiol Cell Physiol. 2012 Jun 1;302(11):C1652-60.
26 Pharmacogenomics in aspirin intolerance. Curr Drug Metab. 2009 Nov;10(9):998-1008.
27 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
28 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
29 Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clin Pharmacol Ther. 2003 Mar;73(3):264-71.
30 Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics. Pharmacogenomics. 2010 Jul;11(7):951-8. doi: 10.2217/pgs.10.65.
31 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
32 Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel. Clin Pharmacol Ther. 2011 Oct;90(4):612-9. doi: 10.1038/clpt.2011.163. Epub 2011 Sep 7.
33 The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. Clin Exp Allergy. 2005 Mar;35(3):339-44. doi: 10.1111/j.1365-2222.2004.02197.x.
34 Genetic and ethnic risk factors associated with drug hypersensitivity. Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):280-90. doi: 10.1097/ACI.0b013e32833b1eb3.
35 Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol. 2009 Dec 10;27(35):5972-8.
36 Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms. J Am Coll Cardiol. 2003 Sep 17;42(6):1115-9. doi: 10.1016/s0735-1097(03)00921-5.
37 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
38 Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
39 Association between treatment-emergent suicidal ideation with citalopram and polymorphisms near cyclic adenosine monophosphate response element binding protein in the STAR*D study. Arch Gen Psychiatry. 2007 Jun;64(6):689-97. doi: 10.1001/archpsyc.64.6.689.
40 A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet. 2010 Aug;42(8):711-4. doi: 10.1038/ng.632. Epub 2010 Jul 18.
41 Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity. Pharmacogenomics J. 2007 Dec;7(6):395-403. doi: 10.1038/sj.tpj.6500435. Epub 2007 Jan 23.
42 A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthma. Immunogenetics. 2011 Jan;63(1):13-21. doi: 10.1007/s00251-010-0490-8. Epub 2010 Nov 18.
43 HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity. PLoS One. 2013 Jul 9;8(7):e68111. doi: 10.1371/journal.pone.0068111. Print 2013.
44 Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. Transl Psychiatry. 2012 Jul 3;2(7):e129. doi: 10.1038/tp.2012.57.
45 Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol. 2004 Feb;65(2):470-8.
46 Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression. Atherosclerosis. 2005 Nov;183(1):49-55.
47 Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells. Biochem J. 2006 Feb 15;394(Pt 1):317-24.
48 Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase. J Physiol Pharmacol. 2006 Nov;57 Suppl 5:125-36.
49 Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
50 Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
51 Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. Chem Res Toxicol. 2012 Dec 17;25(12):2725-36.
52 Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomed Pharmacother. 2010 Feb;64(2):118-23. doi: 10.1016/j.biopha.2009.04.033. Epub 2009 Oct 17.
53 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
54 Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem. 2005 Dec 9;280(49):41047-56. doi: 10.1074/jbc.M503713200. Epub 2005 Sep 30.
55 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
56 Aspirin enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in hormone-refractory prostate cancer cells through survivin down-regulation. Mol Pharmacol. 2007 Dec;72(6):1586-92. doi: 10.1124/mol.107.039610. Epub 2007 Sep 11.
57 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
58 Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem Pharmacol. 2004 Feb 1;67(3):411-9. doi: 10.1016/j.bcp.2003.09.014.
59 Sudden onset of ornithine carbamoyltransferase deficiency after aspirin ingestion. J Inherit Metab Dis. 1993;16(5):917. doi: 10.1007/BF00714301.
60 Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease. Thromb Res. 2007;119(3):301-3. doi: 10.1016/j.thromres.2006.03.005. Epub 2006 May 3.
61 Time-dependent effects of low-dose aspirin on plasma renin activity, aldosterone, cortisol, and catecholamines. Hypertension. 2009 Nov;54(5):1136-42. doi: 10.1161/HYPERTENSIONAHA.109.134825. Epub 2009 Oct 5.
62 Low-dose aspirin. I. Effect on angiotensin II pressor responses and blood prostaglandin concentrations in pregnant women sensitive to angiotensin II. Am J Obstet Gynecol. 1988 Nov;159(5):1035-43. doi: 10.1016/0002-9378(88)90406-1.
63 Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
64 Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells. Int J Cancer. 1997 Dec 10;73(6):880-4. doi: 10.1002/(sici)1097-0215(19971210)73:6<880::aid-ijc20>3.0.co;2-7.
65 Moderation of the platelet releasate response by aspirin. Blood. 2007 Jun 1;109(11):4786-92. doi: 10.1182/blood-2006-07-038539. Epub 2007 Feb 15.
66 Aspirin inhibits ErbB2 to induce apoptosis in cervical cancer cells. Med Oncol. 2010 Jun;27(2):379-87. doi: 10.1007/s12032-009-9221-0. Epub 2009 May 8.
67 Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells. Int J Oncol. 2009 Mar;34(3):597-608. doi: 10.3892/ijo_00000185.
68 Selective inhibition of interleukin-4 gene expression in human T cells by aspirin. Blood. 2001 Mar 15;97(6):1742-9. doi: 10.1182/blood.v97.6.1742.
69 The proapoptotic effects of sulindac, sulindac sulfone and indomethacin are mediated by nucleolar translocation of the RelA(p65) subunit of NF-kappaB. Oncogene. 2008 Apr 17;27(18):2648-55. doi: 10.1038/sj.onc.1210891. Epub 2007 Dec 3.
70 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
71 The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. Mol Carcinog. 2010 Mar;49(3):235-46. doi: 10.1002/mc.20593.
72 Aspirin Has Antitumor Effects via Expression of Calpain Gene in Cervical Cancer Cells. J Oncol. 2008;2008:285374. doi: 10.1155/2008/285374. Epub 2008 Sep 29.
73 A comparison of the effectiveness of selected non-steroidal anti-inflammatory drugs and their derivatives against cancer cells in vitro. Cancer Chemother Pharmacol. 2008 Feb;61(2):203-14. doi: 10.1007/s00280-007-0462-3. Epub 2007 Apr 20.
74 Effect of aspirin treatment on serum concentrations of lipoprotein(a) in patients with atherosclerotic diseases. Clin Chem. 2002 Sep;48(9):1454-9.
75 Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells. Am J Physiol Cell Physiol. 2005 Sep;289(3):C557-63. doi: 10.1152/ajpcell.00045.2005. Epub 2005 May 18.
76 Aspirin induces apoptosis through release of cytochrome c from mitochondria. Neoplasia. 2000 Nov-Dec;2(6):505-13. doi: 10.1038/sj.neo.7900120.
77 Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
78 Acetylsalicylic acid--induced hemolysis and its mechanism. J Clin Invest. 1970 Jul;49(7):1334-40. doi: 10.1172/JCI106349.
79 Chronic aspirin use suppresses CDH1 methylation in human gastric mucosa. Dig Dis Sci. 2010 Jan;55(1):54-9. doi: 10.1007/s10620-008-0701-4. Epub 2009 Jan 29.
80 Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3) (2+) electrochemiluminescence detection. Electrophoresis. 2006 Oct;27(20):4047-51. doi: 10.1002/elps.200600197.
81 Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells. Biochim Biophys Acta. 2006 Mar;1763(3):282-9. doi: 10.1016/j.bbamcr.2006.01.005. Epub 2006 Feb 21.
82 Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs. J Biol Chem. 2002 Oct 11;277(41):38212-21. doi: 10.1074/jbc.M205142200. Epub 2002 Jul 29.
83 Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
84 Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
85 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
86 Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY). 2012 Dec;4(12):952-65. doi: 10.18632/aging.100521.
87 Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
88 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
89 Effects of low-dose aspirin on acute inflammatory responses in humans. J Immunol. 2009 Aug 1;183(3):2089-96. doi: 10.4049/jimmunol.0900477. Epub 2009 Jul 13.
90 [Aspirin inhibits proliferation and expression of p44/42 MAPK phosphorylation in vascular endothelial cells]. Di Yi Jun Yi Da Xue Xue Bao. 2004 Sep;24(9):1013-5.
91 Restoration by aspirin of impaired plasma maspin level in human breast cancer. Acta Oncol. 2006;45(2):184-7. doi: 10.1080/02841860500516584.
92 Aspirin induces apoptosis through mitochondrial cytochrome c release. FEBS Lett. 2000 Sep 1;480(2-3):193-6. doi: 10.1016/s0014-5793(00)01922-0.
93 Aspirin inhibits proliferation of gemcitabine-resistant human pancreatic cancer cells and augments gemcitabine-induced cytotoxicity. Acta Pharmacol Sin. 2010 Jan;31(1):73-80. doi: 10.1038/aps.2009.172. Epub 2009 Dec 7.
94 Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels. Clin Cancer Res. 2008 May 15;14(10):3168-76. doi: 10.1158/1078-0432.CCR-07-4362.
95 Association of the CCR3 gene polymorphism with aspirin exacerbated respiratory disease. Respir Med. 2010 May;104(5):626-32. doi: 10.1016/j.rmed.2009.11.024. Epub 2009 Dec 21.
96 Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
97 Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
98 Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
99 Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide. Chem Biol Interact. 2023 Sep 1;382:110644. doi: 10.1016/j.cbi.2023.110644. Epub 2023 Jul 25.
100 Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta. Mol Cell Biochem. 2004 Nov;266(1-2):57-63. doi: 10.1023/b:mcbi.0000049138.67699.7b.
101 Aspirin upregulates expression of urokinase type plasminogen activator receptor (uPAR) gene in human colon cancer cells through AP1. Biochem Biophys Res Commun. 2006 Sep 22;348(2):618-27. doi: 10.1016/j.bbrc.2006.07.098. Epub 2006 Jul 28.
102 Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. Br J Cancer. 2004 Jul 19;91(2):381-8. doi: 10.1038/sj.bjc.6601913.
103 Failure of apoptosis and activation on NFkappaB by celecoxib and aspirin in lung cancer cell lines. Oncol Rep. 2007 Apr;17(4):823-8.
104 Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis. 2001 Sep;22(9):1393-7. doi: 10.1093/carcin/22.9.1393.
105 Low-dose aspirin reduces the gene expression of gastrokine-1 in the antral mucosa of healthy subjects. Aliment Pharmacol Ther. 2008 Sep 15;28(6):782-8. doi: 10.1111/j.1365-2036.2008.03793.x.
106 Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity. J Clin Immunol. 2007 Nov;27(6):613-9. doi: 10.1007/s10875-007-9115-x. Epub 2007 Jul 20.
107 KIF3A, a cilia structural gene on chromosome 5q31, and its polymorphisms show an association with aspirin hypersensitivity in asthma. J Clin Immunol. 2011 Feb;31(1):112-21. doi: 10.1007/s10875-010-9462-x. Epub 2010 Oct 5.
108 Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma. Clin Exp Allergy. 2009 Jul;39(7):972-81. doi: 10.1111/j.1365-2222.2009.03229.x. Epub 2009 Mar 27.
109 Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Hum Mol Genet. 2004 Dec 15;13(24):3203-17. doi: 10.1093/hmg/ddh332. Epub 2004 Oct 20.
110 Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population. BMC Med Genet. 2010 Sep 23;11:138. doi: 10.1186/1471-2350-11-138.
111 Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. Am J Psychiatry. 2007 Oct;164(10):1530-8. doi: 10.1176/appi.ajp.2007.06122018.
112 Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Hum Genet. 2005 Jun;117(1):16-26. doi: 10.1007/s00439-005-1285-0. Epub 2005 Apr 2.
113 Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. Thromb Haemost. 2006 Feb;95(2):253-9. doi: 10.1160/TH05-07-0516.
114 Variable number of tandem repeats polymorphism of platelet glycoprotein Ib alpha in Chinese people and CC genotype with aspirin sensitivity in patients with cerebral infarction. J Clin Pharm Ther. 2009 Apr;34(2):239-43. doi: 10.1111/j.1365-2710.2008.00992.x.
115 Role of Toll-like Receptor 3 Variants in Aspirin-Exacerbated Respiratory Disease. Allergy Asthma Immunol Res. 2011 Apr;3(2):123-7. doi: 10.4168/aair.2011.3.2.123. Epub 2010 Oct 14.
116 Association analysis of RGS7BP gene polymorphisms with aspirin intolerance in asthmatic patients. Ann Allergy Asthma Immunol. 2011 Apr;106(4):292-300.e6. doi: 10.1016/j.anai.2010.10.021. Epub 2011 Jan 8.
117 Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients. Pharmacogenomics. 2011 Mar;12(3):351-63. doi: 10.2217/pgs.10.181.
118 A functional promoter polymorphism of the human IL18 gene is associated with aspirin-induced urticaria. Br J Dermatol. 2011 Nov;165(5):976-84. doi: 10.1111/j.1365-2133.2011.10467.x. Epub 2011 Sep 15.
119 Variations in the STK10 gene and possible associations with aspirin-intolerant asthma in a Korean population. J Investig Allergol Clin Immunol. 2011;21(5):378-88.
120 Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver. Biol Pharm Bull. 1997 Aug;20(8):869-73. doi: 10.1248/bpb.20.869.
121 Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics. Clin Exp Allergy. 2008 Nov;38(11):1727-37. doi: 10.1111/j.1365-2222.2008.03082.x. Epub 2008 Aug 24.
122 Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population. Neuroepidemiology. 2004 May-Jun;23(3):135-43. doi: 10.1159/000075957.
123 Possible association of SLC22A2 polymorphisms with aspirin-intolerant asthma. Int Arch Allergy Immunol. 2011;155(4):395-402. doi: 10.1159/000321267. Epub 2011 Feb 22.
124 Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites. Pharmacogenetics. 2003 Aug;13(8):473-80. doi: 10.1097/00008571-200308000-00005.
125 Functional variability of the adenosine A3 receptor (ADORA3) gene polymorphism in aspirin-induced urticaria. Br J Dermatol. 2010 Nov;163(5):977-85. doi: 10.1111/j.1365-2133.2010.09983.x.
126 IL-13 and IL-17A gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2011 Dec;107(6):510-6. doi: 10.1016/j.anai.2011.09.003. Epub 2011 Sep 22.
127 Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. Respir Med. 2009 Mar;103(3):356-63. doi: 10.1016/j.rmed.2008.10.008. Epub 2008 Nov 18.
128 The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland. Cancer Epidemiol Biomarkers Prev. 2005 Jul;14(7):1613-8. doi: 10.1158/1055-9965.EPI-04-0878.
129 Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population. Ann Hum Genet. 2010 Jul;74(4):326-34.
130 A polymorphism of MS4A2 (- 109T > C) encoding the beta-chain of the high-affinity immunoglobulin E receptor (FcepsilonR1beta) is associated with a susceptibility to aspirin-intolerant asthma. Clin Exp Allergy. 2006 Jul;36(7):877-83. doi: 10.1111/j.1365-2222.2006.02443.x.
131 Association of the platelet membrane glycoprotein I a C807T gene polymorphism with aspirin resistance. J Huazhong Univ Sci Technolog Med Sci. 2007 Dec;27(6):664-7. doi: 10.1007/s11596-007-0611-2.
132 Putative association of SMAPIL polymorphisms with risk of aspirin intolerance in asthmatics. J Asthma. 2010 Nov;47(9):959-65. doi: 10.1080/02770903.2010.514637.
133 Plasma levels of the growth arrest-specific gene 6 product (Gas6) and antiplatelet drug responsiveness in healthy subjects. J Thromb Haemost. 2006 Oct;4(10):2283-4. doi: 10.1111/j.1538-7836.2006.02155.x.
134 ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients. Gastroenterology. 2010 Oct;139(4):1190-7. doi: 10.1053/j.gastro.2010.06.071. Epub 2010 Jul 14.
135 Association of PTGER gene family polymorphisms with aspirin intolerant asthma in Korean asthmatics. BMB Rep. 2010 Jun;43(6):445-9. doi: 10.5483/bmbrep.2010.43.6.445.
136 Genetic determinants of response to aspirin: appraisal of 4 candidate genes. Thromb Res. 2011 Jul;128(1):47-53. doi: 10.1016/j.thromres.2011.02.019. Epub 2011 Mar 22.
137 ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet. 2007;52(1):66-72. doi: 10.1007/s10038-006-0081-6. Epub 2006 Oct 24.
138 Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. Br J Dermatol. 2006 Feb;154(2):256-60. doi: 10.1111/j.1365-2133.2005.06851.x.
139 Association of beta 2-adrenergic receptor polymorphism with the phenotype of aspirin-intolerant acute urticaria. Yonsei Med J. 2007 Dec 31;48(6):1079-81. doi: 10.3349/ymj.2007.48.6.1079.
140 Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha. Am J Epidemiol. 2006 Nov 15;164(10):984-9. doi: 10.1093/aje/kwj294. Epub 2006 Aug 24.
141 Pharmacogenetics of ABCG2 and adverse reactions to gefitinib. J Natl Cancer Inst. 2006 Dec 6;98(23):1739-42.
142 Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline. J Hum Genet. 2011 Sep;56(9):652-9. doi: 10.1038/jhg.2011.75. Epub 2011 Jul 28.
143 Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. BMC Pulm Med. 2010 Jun 1;10:34. doi: 10.1186/1471-2466-10-34.
144 Galectin-10 mRNA is overexpressed in peripheral blood of aspirin-induced asthma. Allergy. 2008 Jan;63(1):125-31. doi: 10.1111/j.1398-9995.2007.01558.x. Epub 2007 Oct 15.
145 Genome-wide and follow-up studies identify CEP68 gene variants associated with risk of aspirin-intolerant asthma. PLoS One. 2010 Nov 3;5(11):e13818. doi: 10.1371/journal.pone.0013818.
146 CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles. Pharmacogenetics. 1998 Dec;8(6):529-41. doi: 10.1097/00008571-199812000-00010.
147 Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma. J Allergy Clin Immunol. 2009 Oct;124(4):779-85.e6. doi: 10.1016/j.jaci.2009.07.044. Epub 2009 Sep 19.
148 ClinicalTrials.gov (NCT01598337) The Effect Of Antiplatelets Therapy On Saphenous Vein Coronary Artery Bypass Graft Patency
149 ClinicalTrials.gov (NCT01589978) PROMUS Element Plus US Post-Approval Study