Details of the Drug Combinations

General Information of This Drug (ID: DM84ZXF)

• Drug Name: Lorazepam (DM84ZXF)
• Synonyms: Almazine; Alzapam; Anxiedin; Anxira; Anzepam; Aplacasse; Aplacassee; ApoLorazepam; Aripax; Ativan; Azurogen; Bonatranquan; Bonton; Delormetazepam; Demethyllormetazepam; Donix; Duralozam; Durazolam; Efasedan; Emotion; Emotival; Equitam; Idalprem; Kalmalin; Larpose; Laubeel; Lomesta; Lopam; Lorabenz; Lorafen; Loram; Lorans; Lorapam; Lorat; Lorax; Loraz; Lorazene; Lorazep; Lorazepamum; Lorazin; Lorazon; Lorenin; Loridem; Lorivan; Lorsedal; Lorsilan; Lorzem; Lozepam; Merlit; Nervistopl; Norlormetazepam; Novhepar; Novolorazem; NuLoraz; Orfidal; Punktyl; Quait; Renaquil; Rocosgen; Securit; Sedatival; Sedazin; Sedicepan; Sedizepan; Sidenar; Silence; Sinestron; Somagerol; Stapam; Tavor; Temesta; Tolid; Tranqipam; Trapax; Upan; Vigiten; Wypax; AHP Brand of Lorazepam; Apo Lorazepam; Apotex Brand of Lorazepam; Baxter Brand of Lorazepam; Ct Arzneimittel Brand of Lorazepam; Desitin Brand of Lorazepam; Dolorgiet Brand of Lorazepam; Llorens Brand of Lorazepam; Lorazep von ct; Lorazepam AHP Brand; Lorazepam Apotex Brand; Lorazepam Baxter Brand; Lorazepam Desitin Brand; Lorazepam Dolorgiet Brand; Lorazepam Fabra; Lorazepam Genericon; Lorazepam Intensol; Lorazepam Lannacher; Lorazepam Llorens Brand; Lorazepam Medical; Lorazepam Medical Brand; Lorazepam Medix Brand; Lorazepam Novartis Brand; Lorazepam Novopharm Brand; Lorazepam Riemser Brand; Lorazepam Wyeth Brand; Lorazepam neuraxpharm; Lorazepam neuraxpharm Brand; Lorazepam preservative free; Lorazepam ratiopharm; Lorazepam ratiopharm Brand; Lorazepan Chobet; Lorazepan Richet; Max Pax; Medical Brand of Lorazepam; Medix Brand of Lorazepam; Merck dura Brand of Lorazepam; Nervistop L; Neuraxpharm Brand of Lorazepam; Novartis Brand of Lorazepam; Novo Lorazem; Novopharm Brand of Lorazepam; Nu Loraz; Nu Pharm Brand of Lorazepam; Orfidal Wyeth; Pro dorm; Ratiopharm Brand of Lorazepam; Riemser Brand of Lorazepam; Serra Pamies Brand of Lorazepam; Wyeth Brand of Lorazepam; L1764_SIGMA; WY4036; Wy 4036; Apo-Lorazepam; Ativan (TN); Ct-Arzneimittel Brand of Lorazepam; Lorazepam (Ativan); Lorazepam Nu-Pharm Brand; Lorazepam ct-Arzneimittel Brand; Lorazepam-Efeka; Lorazepam-neuraxpharm; Lorazepam-ratiopharm; Lorazepamum [INN-Latin]; Medical, Lorazepam; Novo-Lorazem; Nu-Loraz; Nu-Pharm Brand of Lorazepam; O-Chlorooxazepam; O-Chloroxazepam; Temesta (TN); Wy-4036; Wyeth, Orfidal; Lorazepam (JP15/USP/INN); Lorazepam [USAN:INN:BAN:JAN]; (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; (+/-)-Lorazepam; 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one; 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

Indication

Absence epilepsy; ICD 11: N.A.; Status: Approved [1]; Anxiety; ICD 11: N.A.; Status: Approved [1]; Anxiety disorder; ICD 11: 6B00-6B0Z; Status: Approved [2]; Nausea; ICD 11: MD90; Status: Approved [1]; Panic disorder; ICD 11: 6B01; Status: Approved [1]; Vomiting; ICD 11: MD90; Status: Approved [1]

• Therapeutic Class: Antianxiety Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Baclofen + Lorazepam	DC6PA2K	Baclofen	Alcohol Withdrawal Delirium	[3]
Clonidine + Lorazepam	DC648ND	Clonidine	Opiate Addiction	[4]
Lorazepam + Ibuprofen	DCTEYR2	Ibuprofen	Subfertility	[5]
Pentazocine + Lorazepam	DC937MZ	Pentazocine	Bipolar Disorder	[6]
Lorazepam + Haloperidol	DC173WM	Haloperidol	Methamphetamine Intoxication (Disorder)	[7]
Lorazepam + Haloperidol	DCHQKZL	Haloperidol	Delirium	[8]
Lorazepam + Haloperidol	DCNZ4I9	Haloperidol	Advanced Cancers	[9]
Lorazepam + Clonazepam	DCK4JJ7	Clonazepam	Epilepsia Partialis Continua	[10]
Lorazepam + Promethazine	DCISUD6	Promethazine	Peripheral Vertigo.	[11]
Lorazepam + Ibuprofen	DC25V5X	Ibuprofen	Pain	[12]
Topiramate + Lorazepam	DC2NI8D	Topiramate	Cognitive Deficits	[13]

References

• [1] Lorazepam FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5884).
• [3] ClinicalTrials.gov (NCT00597701) Treating Alcohol Withdrawal With Oral Baclofen
• [4] ClinicalTrials.gov (NCT02362256) The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism
• [5] ClinicalTrials.gov (NCT02863614) Analgesia for Endometrial Scratching
• [6] ClinicalTrials.gov (NCT00431184) Effects of Pentazocine Versus Lorazepam on Manic Symptoms
• [7] ClinicalTrials.gov (NCT04715230) Meth-OD: A Study of IXT-m200 in Patients With Toxicity From Methamphetamine Overdose (Meth-OD). U.S. National Institutes of Health.
• [8] ClinicalTrials.gov (NCT03743649) Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care
• [9] ClinicalTrials.gov (NCT01949662) Haloperidol and Lorazepam for Delirium in Patients With Advanced Cancer
• [10] ClinicalTrials.gov (NCT02134366) Clobazam Use in Epilepsia Partialis Continua - Pilot Study
• [11] ClinicalTrials.gov (NCT01827293) Promethazine vs. Lorazepam for Treatment of Vertigo
• [12] ClinicalTrials.gov (NCT01330459) Hydrocodone For Pain Control in First Trimester Surgical Abortion
• [13] ClinicalTrials.gov (NCT01889602) Characterizing and Predicting Drug Effects on Cognition