Details of the Drug Combinations

General Information of This Drug (ID: DM89JLN)

• Drug Name: Apixaban (DM89JLN)
• Synonyms: GG2; BMS 562247-01; BMS-562247; Eliquis (TN); BMS-562247-01; Apixaban (JAN/USAN/INN); BMS-562247-01, Apixaban; Ro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide; 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahyd

Indication

Thrombosis; ICD 11: DB61-GB90; Status: Approved [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

8 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Apixaban + DU-176B	DCCZT3O	DU-176B	Atrial Fibrillation	[2]
Apixaban + Cyclosporin A	DCQY312	Cyclosporin A	Venous Thromboembolism	[3]
Apixaban + Tacrolimus	DCVQ929	Tacrolimus	Venous Thromboembolism	[3]
Clarithromycin + Apixaban	DCVWGS6	Clarithromycin	Venous Thromboembolism	[4]
Apixaban + Rivaroxaban	DCMI6XF	Rivaroxaban	Cancer-associated Thrombosis	[5]
Apixaban + DU-176B	DCQGYWA	DU-176B	Aortic Stenosis	[6]
Apixaban + Rivaroxaban	DCFC0H9	Rivaroxaban	Renal Insufficiency	[7]
Apixaban + Warfarin	DCQQ11V	Warfarin	Acute Myocardial Infarction	[8]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6390).
• [2] ClinicalTrials.gov (NCT05262322) Study to Evaluate the Use of Direct Oral Anticoagulants in UK Clinical Practice For Patients With a First Stroke Attributable to Nonvalvular Atrial Fibrillation
• [3] ClinicalTrials.gov (NCT03083782) Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus
• [4] ClinicalTrials.gov (NCT02912234) Effect of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Participants
• [5] ClinicalTrials.gov (NCT03139487) A Randomized Phase II Open Label Study to Compare the Safety and Efficacy of Subcutaneous Dalteparin Versus Direct Oral Anticoagulants for Cancer-associated Venous Thromboembolism
• [6] ClinicalTrials.gov (NCT05035277) AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation
• [7] ClinicalTrials.gov (NCT02664155) Venous Thromboembolism in Renally Impaired Patients and Direct Oral Anticoagulants
• [8] ClinicalTrials.gov (NCT03232398) Apixaban Versus Warfarin in Patients With Left Ventricular (LV) Thrombus