Details of the Drug Combinations

General Information of This Drug (ID: DM8BKU9)

Drug Name
Acitretin   DM8BKU9
Synonyms
Acitretina; Acitretine; Acitretinum; Etretin; Isoacitretin; Isoetretin; Neotigason; Soriatane; TMMP; Acitretina [Spanish]; Acitretine [French]; Acitretinum [Latin]; Retinoid etretin; U0279; Ro 10-1670; Ro 13-7652; Soriatane (TN); Soriatane, Acitretin; Acitretin (USAN/INN); Acitretin [USAN:INN:BAN]; All-trans-Acitretin; Ro 10-1670/000; Ro-10-1670; Ro-13-7652; Ro-10-1670/000; All-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid; (2E,4E,6E,8E)-3,7-dimethyl-9-[2,3,6-trimethyl-4-(methyloxy)phenyl]nona-2,4,6,8-tetraenoic acid; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 13-cis-Acitretin; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid
Indication
Disease Entry ICD 11 Status REF
Psoriasis vulgaris EA90 Approved [1]
Therapeutic Class
Keratolytic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

91 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acitretin + Citalopram DCLM1XD Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Repaglinide DCWM2FI Repaglinide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Sivelestat DC1N64N Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Fomepizole DC8YYBS Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Triapine DCS33OL Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Dexmedetomidine DCTRKWK Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Dronedarone DCZNXD6 Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Pamidronate DCQ5PJ9 Pamidronate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Isosorbide dinitrate DCK8JRV Isosorbide dinitrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Testosterone cypionate DCSW3FJ Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Guanfacine DCCXCZ2 Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Emetine DCMB8EX Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Metformin DC00B2W Metformin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + ETHISTERONE DCK21CK ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Phensuximide DCGZD54 Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Diphenidol DCD95ZT Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Sulfapyridine DCNEZXN Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + PF-02545920 DC68296 PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Lubiprostone DCTF8ZB Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Oseltamivir DC1GBUZ Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Diazoxide DC8OIB7 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Fenoprofen DC5FPWN Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Tamoxifen DCIIEW4 Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Allopurinol DC4CU37 Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Idarubicin DCHV5KZ Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Idarubicin DCDVCHS Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Acitretin + Methocarbamol DCFPMSE Methocarbamol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Darunavir DC0KD6C Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Tropisetron DCAP5RQ Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Artemisinin DC3ZZTL Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Clascoterone DCO9PFF Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Cefmenoxime DCRI67B Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Maprotiline DCTZJXK Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole DC20B88 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Leflunomide DCQSNT8 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Amiloride DCNEG2E Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Brincidofovir DCOQM53 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Chloroquine DCIUAC9 Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Pizotyline DCU2XGQ Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Fosfomycin DC8P1GH Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Zileuton DCK8IVU Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Silver sulfadiazine DCR704T Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Testolactone DC6MZ8Z Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Cerivastatin DCVBO9K Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Metaxalone DC6KYDV Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Acetohydroxamic Acid DCICLM2 Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Etomidate DCYSHXN Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aliskiren + Acitretin DC4EZ3B Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amodiaquine + Acitretin DCKJ24X Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Acitretin DCXO6QN Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Atenolol + Acitretin DCNIUZL Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Azatadine + Acitretin DC83KRJ Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Acitretin DCCGGLT Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Acitretin DCWLTH8 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + Acitretin DCWXTGY Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cinacalcet + Acitretin DCGXF2M Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clindamycin + Acitretin DCZ2C99 Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clopidogrel + Acitretin DC3HPPH Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dichlorphenamide + Acitretin DCQEBSK Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diethylcarbamazine + Acitretin DCLO9O3 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxapram + Acitretin DCZKNSX Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Efavirenz + Acitretin DCBCNJH Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Eflornithine + Acitretin DCO3IJL Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + Acitretin DCL7YCX Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Estramustine + Acitretin DCMB0QF Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Everolimus + Acitretin DCNBZ6F Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ezetimibe + Acitretin DC56CPB Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + Acitretin DC8DJYE Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ginsenoside Rb1 + Acitretin DCDI0VM Ginsenoside Rb1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hyodeoxycholic acid + Acitretin DC2SPO3 Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Acitretin DCPVQK2 Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + Acitretin DCRVSRK Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebutamate + Acitretin DC67THK Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mecamylamine + Acitretin DCL38XO Mecamylamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + Acitretin DCJSQ00 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Acitretin DCRP1UG Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nabilone + Acitretin DCIUBY6 Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Niclosamide + Acitretin DCQANWT Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Olmesartan medoxomil + Acitretin DC4LQ2X Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pazopanib + Acitretin DCSC8U0 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pentamidine + Acitretin DCID040 Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Acitretin DCJ2PEZ PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Acitretin DC99MFK Procarbazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ribavirin-TP + Acitretin DCUAKXC Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sertraline + Acitretin DCHYKIR Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sumatriptan + Acitretin DCGUA00 Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrine + Acitretin DCEGV2B Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolazoline + Acitretin DCFA5M5 Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + Acitretin DC09UEV Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triamterene + Acitretin DC5559W Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Acitretin DC3TUPZ Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 91 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Vemurafenib + Acitretin DC1JEAH Vemurafenib Malignant Melanoma [4]
Methotrexate + Acitretin DCJN91L Methotrexate Plaque Psoriasis [5]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7598).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT02050321) A Phase II Study of Vemurafenib Combined With Acitretin in Patients With Advanced Melanoma
5 ClinicalTrials.gov (NCT04239859) Outcomes With Treatment and Withdraw of Secukinumab in Patients With Plaque Psoriasis