Details of the Drug Combinations

General Information of This Drug (ID: DM8RZ9H)

• Drug Name: Eszopiclone (DM8RZ9H)
• Synonyms: Esopiclone; Estorra; Lunesta; Lunivia; Estorra (TN); Eszopiclone [USAN:INN]; KS-1055; SEP-0227018; SEP-0227108; SEP-190; SEP-225441; Eszopiclone (JAN/USAN/INN); [(7S)-6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate; (+)-(5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate; (5S)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate; (5S)-6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate; (5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate; (S)-Zopiclone; (plus)-Zopiclone; 1-Piperazinecarboxylic acid, 4-methyl-, (5S)-6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester

Indication

Insomnia; ICD 11: 7A00-7A0Z; Status: Approved [1]

• Therapeutic Class: Hypnotics and Sedatives
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

3 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Eszopiclone + Piperaquine	DCBR1AO	Piperaquine	DD2 (Cell Line: DD2)	[2]
Eszopiclone + Lumefantrine	DCDZ18S	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Eszopiclone + Piperaquine	DC009XW	Piperaquine	Hepatoblastoma (Cell Line: HB3)	[3]

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bupropion + Eszopiclone	DCDKOQP	Bupropion	Insomnia	[4]
Eszopiclone + Escitalopram	DC6ZDAA	Escitalopram	Insomnia	[5]
Eszopiclone + Venlafaxine	DCH0JYQ	Venlafaxine	Major Depressive Disorder	[6]
Eszopiclone + Fluoxetine	DCPCT7O	Fluoxetine	Sleep Initiation and Maintenance Disorders	[7]
Ramelteon + Eszopiclone	DC7LCRZ	Ramelteon	Marijuana Dependence	[8]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7429).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] ClinicalTrials.gov (NCT00511134) Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
• [5] ClinicalTrials.gov (NCT00813735) Eszopiclone Co-Administered With Escitalopram for Insomnia in Elderly Adults With Major Depressive Disorder
• [6] ClinicalTrials.gov (NCT00435279) A Study of Eszopiclone Co-administered With Venlafaxine in Subjects With Major Depressive Disorder and Insomnia
• [7] ClinicalTrials.gov (NCT00247624) Improving Sleep and Psychological Functioning in People With Depression and Insomnia
• [8] ClinicalTrials.gov (NCT00893269) The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep