Details of the Drug Combinations

General Information of This Drug (ID: DM8SXYG)

• Drug Name: Lamotrigine (DM8SXYG)
• Synonyms: Crisomet; Labileno; Lamictal; Lamictin; Lamiktal; Lamitor; Lamotrigina; Lamotriginum; Desitin Brand of Lamotrigine; Faes Brand of Lamotrigine; Glaxo Wellcome Brand of Lamotrigine; GlaxoSmithKline Brand of Lamotrigine; Juste Brand of Lamotrigine; Lamictal Cd; Lamictal ODT; Lamictal XR; Lamotrigina [Spanish]; Lamotriginum [Latin]; BW 430C; GI 267119X; GW 273293; L 3791; BW-430C; EUR-1048; Lamictal (TN); Lamictin (TN); Lamotrigine [USAN:INN:BAN]; Lamotrigine (JAN/USAN/INN); 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; 3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine; 3,5-diamino-6-(2,3-dichlorophenyl)-as-triazine; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine; 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diyldiamine; 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

Indication

Bipolar disorder; ICD 11: 6A60; Status: Approved [1]; Epilepsy; ICD 11: 8A60-8A68; Status: Approved [1]

• Therapeutic Class: Anticonvulsants
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ketamine + Lamotrigine	DCU67YY	Ketamine	Major Depression	[2]
Ketamine + Lamotrigine	DCQZTVE	Ketamine	Mental Disorders	[3]
Lamotrigine + Lithium Carbonate	DC1VUOM	Lithium Carbonate	Bipolar Disorder	[4]
Lamotrigine + Raltegravir	DC47DV7	Raltegravir	HIV Infection	[5]
Lamotrigine + Atorvastatin	DC7P73C	Atorvastatin	Epilepsy	[6]
Lamotrigine + Levetiracetam	DCFERNX	Levetiracetam	Epilepsy	[7]
Lamotrigine + Eslicarbazepine acetate	DCLA480	Eslicarbazepine acetate	Epilepsy	[8]
Paroxetine + Lamotrigine	DCVGW2X	Paroxetine	Unipolar Depression	[9]
Zonisamide + Lamotrigine	DCKOFPV	Zonisamide	Epilepsy	[10]
Oxcarbazepine + Lamotrigine	DCJXIS7	Oxcarbazepine	Drug Resistant Epilepsy	[11]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2622).
• [2] ClinicalTrials.gov (NCT00419003) Research Study for Major Depressive Disorder: Investigation of Glutamate Medications
• [3] ClinicalTrials.gov (NCT02708849) The Sustained Effects of Ketamine
• [4] ClinicalTrials.gov (NCT00221975) Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling
• [5] ClinicalTrials.gov (NCT00618241) Pharmacokinetic Study on Raltegravir and Lamotrigine
• [6] ClinicalTrials.gov (NCT00627575) AED/Statin Interaction Study
• [7] ClinicalTrials.gov (NCT05450822) Precision Medicine in the Treatment of Epilepsy
• [8] ClinicalTrials.gov (NCT02283801) Open-label Drug Interaction Study Between Eslicarbazepine Acetate and Lamotrigine.
• [9] ClinicalTrials.gov (NCT00901407) Lamotrigine Augmentation in Resistant Depression
• [10] ClinicalTrials.gov (NCT04939675) Modification of Epilepsy Screen Questionnaire and Treatment Feasibility Evaluation
• [11] ClinicalTrials.gov (NCT05697614) The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children