Details of the Drug Combinations

General Information of This Drug (ID: DM8XP26)

Drug Name

Rolapitant DM8XP26

Synonyms

Rolapitant; 552292-08-7; Sch 619734; Varubi; UNII-NLE429IZUC; SCH-619734; NLE429IZUC; 914462-92-3; (5S,8S)-8-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one; (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one; Rolapitant [USAN:INN]; Varuby; Varubi (TN); Rolapitant (USAN/INN); Rolapitant(sch619734); SCHEMBL354305; GTPL5749; CHEMBL3707331; CHEBI:90908; DTXSID90203740; MolPort-035-942-975; EX-A1288; BCP09609; ZINC3816514

Indication

Disease Entry	ICD 11	Status	REF
Chemotherapy-induced nausea	MD90	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Rolapitant + Sulfasalazine	DCLJ519	Sulfasalazine	Chemotherapy-induced Nausea and Vomiting	[2]
Rolapitant + Digoxin	DCNETTW	Digoxin	Chemotherapy-induced Nausea and Vomiting	[2]
Dexamethasone + Rolapitant	DCDCGY8	Dexamethasone	Germ Cell Tumor	[3]
Rolapitant + Ondansetron	DC0QWMO	Ondansetron	Chemo-radiation Induced Nausea and Vomiting	[4]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5749).
2	ClinicalTrials.gov (NCT02434861) An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects
3	ClinicalTrials.gov (NCT03960151) Rolapitant Plus Olanzapine in Multiday Cisplatin Chemotherapy
4	ClinicalTrials.gov (NCT02991456) Rolapitant as an Antiemetic in Malignant Glioma Patients Receiving Radiotherapy and Temozolomide