Details of the Drug Combinations

General Information of This Drug (ID: DM93L4X)

• Drug Name: Dexmedetomidine (DM93L4X)
• Synonyms: Dexmedetomidina; Dexmedetomidinum; MPV 1440; MPV-1440; Precedex (TN); Dexmedetomidine (USAN/INN); (+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole; 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole; 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole

Indication

Irritability; ICD 11: MB24; Status: Approved [1]; Obstructive sleep apnea; ICD 11: 7A41; Status: Approved [2]; Traumatic brain injury; ICD 11: NA07.Z; Status: Approved [2]; Respiratory failure; ICD 11: CB41; Status: Investigative [2]

• Therapeutic Class: Hypnotics and Sedatives
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

56 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
10-hydroxycamptothecin + Dexmedetomidine	DCAZF4G	10-hydroxycamptothecin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acitretin + Dexmedetomidine	DCTRKWK	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amantadine + Dexmedetomidine	DCKFLYZ	Amantadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Arfolitixorin + Dexmedetomidine	DCQ37CQ	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
AS-1949490 + Dexmedetomidine	DCTQLWP	AS-1949490	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Dexmedetomidine	DCHAQBQ	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Dexmedetomidine	DC8S14Z	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Meclofenamic acid	DC8BWUQ	Meclofenamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Diethylcarbamazine	DCM3YLT	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Citalopram	DCRBERM	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Terazosin	DCUQMFY	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + PMID28460551-Compound-2	DCHP03K	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Vinblastine	DC34LG7	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Mephenytoin	DCI2GH0	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + IT-141	DC4R6TN	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Isosorbide dinitrate	DC61778	Isosorbide dinitrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Docetaxel	DCATO2P	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Sulfinpyrazone	DCYFGMG	Sulfinpyrazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Phensuximide	DCSO5IW	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Armodafinil	DCR3XDU	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + BIO-300	DC5ZPG4	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + PF-02545920	DCC01XF	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Tiagabine	DCMHQB1	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Oseltamivir	DCPNAUV	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Probenecid	DCSWNOP	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Trimethobenzamide	DCEE5UB	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Enalaprilat	DCC5670	Enalaprilat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Maprotiline	DCAZENE	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Leflunomide	DCUBSFB	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Acarbose	DCNLIFF	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Brincidofovir	DCIHRCD	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Mycophenolic acid	DCF9QL4	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Oxandrolone	DCXJC1G	Oxandrolone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Iloprost	DC0JZXN	Iloprost	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Nabilone	DC7GKHT	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Vorinostat	DCWEFBD	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Cerivastatin	DC1TOJ0	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Enoxacin	DCY4D2N	Enoxacin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Albendazole	DCK6IVT	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Dexmedetomidine	DCSONOI	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + Dexmedetomidine	DCV6V56	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ethinyl estradiol + Dexmedetomidine	DCP8XDA	Ethinyl estradiol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Dexmedetomidine	DC5BS1L	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
GINKGOLIDE A + Dexmedetomidine	DC85VBP	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Dexmedetomidine	DCNQ8ID	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Dexmedetomidine	DCCMG3O	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mecamylamine + Dexmedetomidine	DCY9BK0	Mecamylamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + Dexmedetomidine	DC92EKF	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + Dexmedetomidine	DCLF9IQ	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methylene blue + Dexmedetomidine	DCWCPMT	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Dexmedetomidine	DCR51VM	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Dexmedetomidine	DCA3U1N	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pentamidine + Dexmedetomidine	DCR8A2Y	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Quinine + Dexmedetomidine	DCU4J0Z	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
SCH 727965 + Dexmedetomidine	DCF59TD	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triapine + Dexmedetomidine	DCCJZNV	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Epinephrine + Dexmedetomidine	DCWUBUH	Epinephrine	Hemodynamic Instability	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 521).
• [2] Dexmedetomidine FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT02464722) Comparision Between Hemodynamic Response of Dexmedetomidine and Remifentanil on Anesthesia in Endoscopic Sinus Surgery