Details of the Drug Combinations

General Information of This Drug (ID: DM96SE0)

Drug Name

Haloperidol DM96SE0

Synonyms

Aldo; Aloperidin; Aloperidol; Aloperidolo; Aloperidon; Bioperidolo; Brotopon; Dozic; Dozix; Eukystol; Fortunan; Galoperidol; Haldol; Halidol; Halojust; Halol; Halopal; Haloperido; Haloperidolum; Halopidol; Halopoidol; Halosten; Keselan; Linton; Mixidol; Pekuces; Peluces; Peridol; Pernox; Serenace; Serenase; Serenelfi; Sernas; Sernel; Sigaperidol; Ulcolind; Uliolind; Vesalium; Aloperidolo [DCIT]; Aloperidolo [Italian]; Einalon S; Haldol La; Haldol Solutab; Lealgin compositum; Pms Haloperidol; H 1512; R 1625; Aloperidin (TN); Apo-Haloperidol; Bioperidolo (TN); Brotopon (TN); Dozic (TN); Duraperidol (TN); Einalon S (TN); Eukystol (TN); Haldol (TN); Haloperidolum [INN-Latin]; Halosten (TN); Keselan (TN); Linton (TN);Novo-Peridol; Peluces (TN); R-1625; Serenace (TN); Serenase (TN); Sigaperidol (TN); Haloperidol (JP15/USP); McN-JR-1625; Haloperidol (JP15/USP/INN); Haloperidol [USAN:INN:BAN:JAN]

Indication

Disease Entry	ICD 11	Status	REF
Delirium	N.A.	Approved	[1]
Nausea	MD90	Approved	[1]
Psychotic disorder	6A20-6A25	Approved	[1]
Schizophrenia	6A20	Approved	[2]
Vomiting	MD90	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
Tourette syndrome	8A05.00	Investigative	[1]
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Therapeutic Class

Antipsychotic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Haloperidol + Idarubicin	DCN2J0H	Idarubicin	Glioblastoma? (Cell Line: T98G)	[4]
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14 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Flupentixol + Haloperidol	DCU1CLW	Flupentixol	Schizophrenia	[5]
Haloperidol + Zuclopenthixol	DCH1A8H	Zuclopenthixol	Bipolar Disorder	[6]
Haloperidol + SCH 420814	DCQ8G66	SCH 420814	Akathisia, Drug-Induced	[7]
Haloperidol + Olanzapine	DCTOVHA	Olanzapine	Insulin Resistance	[8]
Sertraline + Haloperidol	DCSWTMN	Sertraline	Affective Disorders	[9]
Chlorpromazine + Haloperidol	DCLEL4V	Chlorpromazine	Advanced Malignant Neoplasm	[10]
Haloperidol + Temozolomide	DCLP3LM	Temozolomide	Glioblastoma Multiforme	[11]
Lorazepam + Haloperidol	DC173WM	Lorazepam	Methamphetamine Intoxication (Disorder)	[12]
Lorazepam + Haloperidol	DCHQKZL	Lorazepam	Delirium	[13]
Lorazepam + Haloperidol	DCNZ4I9	Lorazepam	Advanced Cancers	[14]
Haloperidol + Perphenazine	DCRB956	Perphenazine	Schizophrenia	[15]
Haloperidol + Diphenhydramine	DC3WH2F	Diphenhydramine	Migraine Headaches	[16]
Haloperidol + Diphenhydramine	DC6R690	Diphenhydramine	Headache, Migraine	[17]
Haloperidol + Valproic Acid	DCEM9L5	Valproic Acid	Hyperactive Delirium	[18]
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References

1	Haloperidol FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 86).
3	Sigma-1Rs are upregulated via PERK/eIF2/ATF4 pathway and execute protective function in ER stress. Biochem Biophys Res Commun. 2011 Nov 25;415(3):519-25.
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	ClinicalTrials.gov (NCT01164059) Clinical Effectiveness of Newer Antipsychotics in Comparison With Conventional Antipsychotics in Schizophrenia
6	ClinicalTrials.gov (NCT00767715) A Study in the Treatment of Acute Mania
7	ClinicalTrials.gov (NCT00693472) Study of Preladenant for the Treatment of Neuroleptic Induced Akathisia (Study P05145)
8	ClinicalTrials.gov (NCT00625170) Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Antipsychotic Drugs in Healthy Humans
9	ClinicalTrials.gov (NCT00340379) Ziprasidone vs. Sertraline/Haloperidol in Psychotic Depression
10	ClinicalTrials.gov (NCT03021486) Haloperidol With or Without Chlorpromazine in Treating Delirium in Patients With Advanced, Metastatic, or Recurrent Cancer
11	ClinicalTrials.gov (NCT06218524) The Effectiveness of HP and TMZ Synergism on Adult Recurrence GBM
12	ClinicalTrials.gov (NCT04715230) Meth-OD: A Study of IXT-m200 in Patients With Toxicity From Methamphetamine Overdose (Meth-OD). U.S. National Institutes of Health.
13	ClinicalTrials.gov (NCT03743649) Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care
14	ClinicalTrials.gov (NCT01949662) Haloperidol and Lorazepam for Delirium in Patients With Advanced Cancer
15	ClinicalTrials.gov (NCT02199743) Lurasidone Effects on Tissue Glutamate in Schizophrenia
16	ClinicalTrials.gov (NCT02098499) Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial
17	ClinicalTrials.gov (NCT02972502) Efficacy of Haloperidol vs. Metoclopramide for Treatment of Acute Headaches and Migraines in the Emergency Department
18	ClinicalTrials.gov (NCT02343575) Valproic Acid for Treatment of Hyperactive or Mixed Delirium in ICU