DOT Name |
DOT ID |
UniProt ID |
Mode of Action |
REF |
Cytochrome P450 2D6 (CYP2D6)
|
OTZJC802
|
CP2D6_HUMAN
|
Affects Response To Substance
|
[17] |
ATP-dependent translocase ABCB1 (ABCB1)
|
OTEJROBO
|
MDR1_HUMAN
|
Decreases Expression
|
[18] |
D(1A) dopamine receptor (DRD1)
|
OTLZPBT7
|
DRD1_HUMAN
|
Affects Activity
|
[19] |
D(4) dopamine receptor (DRD4)
|
OTAJTO7N
|
DRD4_HUMAN
|
Affects Activity
|
[19] |
Brain-derived neurotrophic factor (BDNF)
|
OTLGH7EW
|
BDNF_HUMAN
|
Increases Expression
|
[20] |
D(3) dopamine receptor (DRD3)
|
OT0OFFKB
|
DRD3_HUMAN
|
Affects Binding
|
[21] |
Superoxide dismutase (SOD1)
|
OT39TA1L
|
SODC_HUMAN
|
Increases ADR
|
[22] |
Catalase (CAT)
|
OTHEBX9R
|
CATA_HUMAN
|
Increases ADR
|
[22] |
G protein-activated inward rectifier potassium channel 1 (KCNJ3)
|
OTHQG16J
|
KCNJ3_HUMAN
|
Increases ADR
|
[22] |
Glutathione S-transferase P (GSTP1)
|
OTLP0A0Y
|
GSTP1_HUMAN
|
Decreases Expression
|
[18] |
Multidrug resistance-associated protein 1 (ABCC1)
|
OTGUN89S
|
MRP1_HUMAN
|
Decreases Expression
|
[18] |
Stearoyl-CoA desaturase (SCD)
|
OTB1073G
|
SCD_HUMAN
|
Increases Expression
|
[23] |
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)
|
OTRT3F3U
|
HMDH_HUMAN
|
Increases Expression
|
[23] |
Fatty acid synthase (FASN)
|
OTFII9KG
|
FAS_HUMAN
|
Increases Expression
|
[23] |
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
|
OTCO26FV
|
HMCS1_HUMAN
|
Increases Expression
|
[23] |
Lathosterol oxidase (SC5D)
|
OT41KMW4
|
SC5D_HUMAN
|
Increases Expression
|
[24] |
Low-density lipoprotein receptor (LDLR)
|
OTH559LU
|
LDLR_HUMAN
|
Increases Expression
|
[24] |
Nuclear protein 1 (NUPR1)
|
OT4FU8C0
|
NUPR1_HUMAN
|
Increases Expression
|
[6] |
Alpha-1-antichymotrypsin (SERPINA3)
|
OT9BP2S0
|
AACT_HUMAN
|
Increases Expression
|
[6] |
Asparagine synthetase (ASNS)
|
OT8R922G
|
ASNS_HUMAN
|
Decreases Expression
|
[6] |
Inhibin beta E chain (INHBE)
|
OTOI2NYG
|
INHBE_HUMAN
|
Increases Expression
|
[6] |
Transgelin (TAGLN)
|
OTAEZ0KP
|
TAGL_HUMAN
|
Decreases Expression
|
[6] |
Nuclear receptor subfamily 0 group B member 2 (NR0B2)
|
OT7UVICX
|
NR0B2_HUMAN
|
Increases Expression
|
[6] |
Lysophospholipase D GDPD3 (GDPD3)
|
OTOHM9QM
|
GDPD3_HUMAN
|
Increases Expression
|
[6] |
Fibronectin type III domain-containing protein 4 (FNDC4)
|
OTOQK0WK
|
FNDC4_HUMAN
|
Increases Expression
|
[6] |
Protein DEPP1 (DEPP1)
|
OTB36PHJ
|
DEPP1_HUMAN
|
Increases Expression
|
[6] |
AP-3 complex subunit beta-1 (AP3B1)
|
OTYTIH5Q
|
AP3B1_HUMAN
|
Increases Expression
|
[7] |
Importin subunit alpha-3 (KPNA4)
|
OTP0EX18
|
IMA3_HUMAN
|
Increases Expression
|
[7] |
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2)
|
OT8L6EGI
|
BCAT2_HUMAN
|
Decreases Expression
|
[7] |
Transmembrane protease serine 2 (TMPRSS2)
|
OTN44YQ5
|
TMPS2_HUMAN
|
Increases Expression
|
[25] |
Period circadian protein homolog 1 (PER1)
|
OTVQF3WX
|
PER1_HUMAN
|
Increases Expression
|
[26] |
Kinesin heavy chain isoform 5C (KIF5C)
|
OT35570Y
|
KIF5C_HUMAN
|
Decreases Expression
|
[7] |
Copine-3 (CPNE3)
|
OTCR3WG2
|
CPNE3_HUMAN
|
Decreases Expression
|
[7] |
CCR4-NOT transcription complex subunit 3 (CNOT3)
|
OT4D5Z9L
|
CNOT3_HUMAN
|
Decreases Expression
|
[7] |
Pyridoxal phosphate homeostasis protein (PLPBP)
|
OT9DZ8P6
|
PLPHP_HUMAN
|
Increases Expression
|
[7] |
Prolactin (PRL)
|
OTWFQGX7
|
PRL_HUMAN
|
Increases Expression
|
[27] |
Fatty acid-binding protein, heart (FABP3)
|
OT562DA1
|
FABPH_HUMAN
|
Increases Expression
|
[7] |
Prothymosin alpha (PTMA)
|
OT2W4T1M
|
PTMA_HUMAN
|
Increases Expression
|
[7] |
Corticoliberin (CRH)
|
OT2MOC4T
|
CRF_HUMAN
|
Decreases Expression
|
[28] |
Profilin-1 (PFN1)
|
OTHTGA1H
|
PROF1_HUMAN
|
Increases Expression
|
[7] |
Signal recognition particle receptor subunit alpha (SRPRA)
|
OT5NMYTY
|
SRPRA_HUMAN
|
Decreases Expression
|
[7] |
Stromelysin-2 (MMP10)
|
OTJDWW8Q
|
MMP10_HUMAN
|
Decreases Expression
|
[7] |
Glycogen phosphorylase, muscle form (PYGM)
|
OTWLVWTV
|
PYGM_HUMAN
|
Decreases Expression
|
[7] |
Histidine--tRNA ligase, cytoplasmic (HARS1)
|
OTHOEOTS
|
HARS1_HUMAN
|
Increases Expression
|
[7] |
Plastin-3 (PLS3)
|
OTYBM4PK
|
PLST_HUMAN
|
Decreases Expression
|
[7] |
Glial fibrillary acidic protein (GFAP)
|
OTQ01ZAS
|
GFAP_HUMAN
|
Decreases Expression
|
[7] |
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)
|
OTJZG0LD
|
GLUT4_HUMAN
|
Increases Expression
|
[29] |
Ezrin (EZR)
|
OTHBPF1Z
|
EZRI_HUMAN
|
Decreases Expression
|
[7] |
V-type proton ATPase subunit B, kidney isoform (ATP6V1B1)
|
OT8FQ7MN
|
VATB1_HUMAN
|
Decreases Expression
|
[7] |
Probable ATP-dependent RNA helicase DDX5 (DDX5)
|
OTLS124U
|
DDX5_HUMAN
|
Decreases Expression
|
[7] |
Vascular endothelial growth factor receptor 1 (FLT1)
|
OTT0OGYS
|
VGFR1_HUMAN
|
Decreases Expression
|
[7] |
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)
|
OTGYVSGU
|
PIMT_HUMAN
|
Decreases Expression
|
[7] |
Cofilin-1 (CFL1)
|
OTT6D5MH
|
COF1_HUMAN
|
Increases Expression
|
[7] |
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)
|
OTJC60Q7
|
THIL_HUMAN
|
Decreases Expression
|
[7] |
5-hydroxytryptamine receptor 2A (HTR2A)
|
OTWXJX0M
|
5HT2A_HUMAN
|
Affects Binding
|
[30] |
General transcription factor IIE subunit 1 (GTF2E1)
|
OTAG9V0I
|
T2EA_HUMAN
|
Decreases Expression
|
[7] |
Stress-induced-phosphoprotein 1 (STIP1)
|
OT7TXLOX
|
STIP1_HUMAN
|
Decreases Expression
|
[7] |
Catenin alpha-1 (CTNNA1)
|
OTFC725Z
|
CTNA1_HUMAN
|
Decreases Expression
|
[7] |
Radixin (RDX)
|
OTNSYUN6
|
RADI_HUMAN
|
Decreases Expression
|
[7] |
Vascular endothelial growth factor receptor 2 (KDR)
|
OT15797V
|
VGFR2_HUMAN
|
Increases Expression
|
[7] |
Transgelin-2 (TAGLN2)
|
OTUXZGDQ
|
TAGL2_HUMAN
|
Decreases Expression
|
[7] |
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)
|
OTIOLNHE
|
LICH_HUMAN
|
Increases Expression
|
[7] |
Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1)
|
OTNBHULA
|
PACR_HUMAN
|
Affects Expression
|
[8] |
Small ribosomal subunit protein eS27 (RPS27)
|
OTFXKY7P
|
RS27_HUMAN
|
Increases Expression
|
[7] |
Cell surface glycoprotein MUC18 (MCAM)
|
OTT8XKGE
|
MUC18_HUMAN
|
Increases Expression
|
[7] |
Vesicle-fusing ATPase (NSF)
|
OTKRJ2ZT
|
NSF_HUMAN
|
Decreases Expression
|
[7] |
Serine--tRNA ligase, cytoplasmic (SARS1)
|
OTFKXQ1O
|
SYSC_HUMAN
|
Decreases Expression
|
[7] |
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)
|
OT50L4XB
|
ACADV_HUMAN
|
Decreases Expression
|
[7] |
Peroxisomal multifunctional enzyme type 2 (HSD17B4)
|
OT8733D7
|
DHB4_HUMAN
|
Decreases Expression
|
[7] |
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)
|
OT6W40XU
|
P5CS_HUMAN
|
Decreases Expression
|
[7] |
Heterogeneous nuclear ribonucleoprotein K (HNRNPK)
|
OTNPRM8U
|
HNRPK_HUMAN
|
Decreases Expression
|
[7] |
Small ribosomal subunit protein uS9 (RPS16)
|
OTVGZOB5
|
RS16_HUMAN
|
Decreases Expression
|
[7] |
Large ribosomal subunit protein eL30 (RPL30)
|
OTLQVY1Z
|
RL30_HUMAN
|
Increases Expression
|
[7] |
Microtubule-associated protein 1A (MAP1A)
|
OTHO8K43
|
MAP1A_HUMAN
|
Decreases Expression
|
[7] |
Large ribosomal subunit protein eL19 (RPL19)
|
OT33LM66
|
RL19_HUMAN
|
Decreases Expression
|
[7] |
Transcriptional activator protein Pur-alpha (PURA)
|
OT975ELW
|
PURA_HUMAN
|
Increases Expression
|
[7] |
Protein Dr1 (DR1)
|
OTR081M4
|
NC2B_HUMAN
|
Decreases Expression
|
[7] |
Synaptic vesicular amine transporter (SLC18A2)
|
OTUOMMM6
|
VMAT2_HUMAN
|
Affects Binding
|
[31] |
Mitochondrial-processing peptidase subunit alpha (PMPCA)
|
OT5X1G9Q
|
MPPA_HUMAN
|
Increases Expression
|
[7] |
Aspartyl/asparaginyl beta-hydroxylase (ASPH)
|
OT3KGDEE
|
ASPH_HUMAN
|
Increases Expression
|
[7] |
Potassium voltage-gated channel subfamily H member 2 (KCNH2)
|
OTZX881H
|
KCNH2_HUMAN
|
Decreases Activity
|
[32] |
Translation initiation factor eIF2B subunit epsilon (EIF2B5)
|
OTV3R4RB
|
EI2BE_HUMAN
|
Increases Expression
|
[7] |
Transcription intermediary factor 1-beta (TRIM28)
|
OTE38OBF
|
TIF1B_HUMAN
|
Decreases Expression
|
[7] |
Condensin complex subunit 2 (NCAPH)
|
OTXOS97C
|
CND2_HUMAN
|
Decreases Expression
|
[7] |
Inorganic pyrophosphatase (PPA1)
|
OTHZK1QB
|
IPYR_HUMAN
|
Increases Expression
|
[7] |
Reticulocalbin-1 (RCN1)
|
OT3JBGAG
|
RCN1_HUMAN
|
Decreases Expression
|
[7] |
Splicing factor 3B subunit 4 (SF3B4)
|
OTGB9OR9
|
SF3B4_HUMAN
|
Decreases Expression
|
[7] |
Disks large homolog 2 (DLG2)
|
OTQ3BD8U
|
DLG2_HUMAN
|
Increases Expression
|
[7] |
Striated muscle preferentially expressed protein kinase (SPEG)
|
OTQXWJR4
|
SPEG_HUMAN
|
Increases Expression
|
[7] |
Cryptochrome-1 (CRY1)
|
OTTGAJT0
|
CRY1_HUMAN
|
Decreases Expression
|
[26] |
Histone H2A type 2-C (H2AC20)
|
OTEIVLM1
|
H2A2C_HUMAN
|
Increases Expression
|
[7] |
Tau-tubulin kinase 1 (TTBK1)
|
OTYW316L
|
TTBK1_HUMAN
|
Increases Expression
|
[7] |
Coiled-coil domain-containing protein 121 (CCDC121)
|
OTWZ4FTT
|
CC121_HUMAN
|
Increases Expression
|
[7] |
Nucleoporin p54 (NUP54)
|
OTHOIRMG
|
NUP54_HUMAN
|
Decreases Expression
|
[7] |
Retinol dehydrogenase 11 (RDH11)
|
OTIND43N
|
RDH11_HUMAN
|
Decreases Expression
|
[7] |
Dynein axonemal heavy chain 3 (DNAH3)
|
OTD2JOKM
|
DYH3_HUMAN
|
Increases Expression
|
[7] |
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38)
|
OTBVB3W5
|
PRP16_HUMAN
|
Decreases Expression
|
[7] |
Small ribosomal subunit protein mS31 (MRPS31)
|
OTB0OBWK
|
RT31_HUMAN
|
Increases Expression
|
[7] |
AP-2 complex subunit mu (AP2M1)
|
OTQCOSFN
|
AP2M1_HUMAN
|
Increases Expression
|
[7] |
Probable ATP-dependent RNA helicase DDX27 (DDX27)
|
OT64NCZ6
|
DDX27_HUMAN
|
Increases Expression
|
[7] |
PDZ and LIM domain protein 5 (PDLIM5)
|
OTLQVV22
|
PDLI5_HUMAN
|
Decreases Expression
|
[7] |
Kremen protein 1 (KREMEN1)
|
OTGJFSAC
|
KREM1_HUMAN
|
Increases Expression
|
[7] |
KH domain-containing RNA-binding protein QKI (QKI)
|
OTTAUGLB
|
QKI_HUMAN
|
Increases Expression
|
[33] |
Transcriptional regulator protein Pur-beta (PURB)
|
OTCDDKYB
|
PURB_HUMAN
|
Decreases Expression
|
[7] |
Melanin-concentrating hormone receptor 1 (MCHR1)
|
OTT57EOE
|
MCHR1_HUMAN
|
Affects Binding
|
[34] |
Transmembrane 9 superfamily member 2 (TM9SF2)
|
OTA0C202
|
TM9S2_HUMAN
|
Decreases Expression
|
[7] |
COP9 signalosome complex subunit 4 (COPS4)
|
OTNK2KS1
|
CSN4_HUMAN
|
Decreases Expression
|
[7] |
Histone H2A.J (H2AJ)
|
OTVA4XTW
|
H2AJ_HUMAN
|
Increases Expression
|
[7] |
MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK)
|
OT20GHN3
|
MK67I_HUMAN
|
Decreases Expression
|
[7] |
ATP-dependent DNA/RNA helicase DHX36 (DHX36)
|
OT8IGL9Y
|
DHX36_HUMAN
|
Decreases Expression
|
[7] |
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13)
|
OT2H0MCE
|
TRM13_HUMAN
|
Decreases Expression
|
[7] |
Tropomodulin-3 (TMOD3)
|
OTQPNSTH
|
TMOD3_HUMAN
|
Decreases Expression
|
[7] |
Endoplasmic reticulum aminopeptidase 1 (ERAP1)
|
OT72S99B
|
ERAP1_HUMAN
|
Decreases Expression
|
[7] |
Ribosome-binding protein 1 (RRBP1)
|
OT4ZTPTM
|
RRBP1_HUMAN
|
Decreases Expression
|
[7] |
DnaJ homolog subfamily B member 11 (DNAJB11)
|
OTDDK2SY
|
DJB11_HUMAN
|
Increases Expression
|
[7] |
Translocation protein SEC63 homolog (SEC63)
|
OT1ICPMK
|
SEC63_HUMAN
|
Increases Expression
|
[7] |
Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)
|
OT3W6F1U
|
CHRD1_HUMAN
|
Increases Expression
|
[7] |
Unconventional myosin-Vb (MYO5B)
|
OTCKL3W3
|
MYO5B_HUMAN
|
Decreases Expression
|
[7] |
Pre-mRNA-processing factor 19 (PRPF19)
|
OTQ1STV3
|
PRP19_HUMAN
|
Increases Expression
|
[7] |
E3 ubiquitin-protein ligase PDZRN3 (PDZRN3)
|
OTQ891OS
|
PZRN3_HUMAN
|
Decreases Expression
|
[7] |
DNA-binding protein SATB2 (SATB2)
|
OT2W80XC
|
SATB2_HUMAN
|
Decreases Expression
|
[7] |
TRPM8 channel-associated factor 1 (TCAF1)
|
OTSQQ37P
|
TCAF1_HUMAN
|
Decreases Expression
|
[7] |
Talin-2 (TLN2)
|
OT10QQBC
|
TLN2_HUMAN
|
Decreases Expression
|
[7] |
Mitogen-activated protein kinase 14 (MAPK14)
|
OT5TCO3O
|
MK14_HUMAN
|
Increases ADR
|
[22] |
Sodium-dependent serotonin transporter (SLC6A4)
|
OT6FGDLW
|
SC6A4_HUMAN
|
Increases ADR
|
[22] |
Dysbindin (DTNBP1)
|
OT9UQT2S
|
DTBP1_HUMAN
|
Increases Response To Substance
|
[35] |
NADH-ubiquinone oxidoreductase chain 1 (ND1)
|
OTCLGIXV
|
NU1M_HUMAN
|
Increases ADR
|
[22] |
Mitogen-activated protein kinase 8 (MAPK8)
|
OTEREYS5
|
MK08_HUMAN
|
Increases ADR
|
[22] |
Synaptosomal-associated protein 25 (SNAP25)
|
OTUIQ81Q
|
SNP25_HUMAN
|
Affects Response To Substance
|
[36] |
------------------------------------------------------------------------------------ |
|
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