Details of the Drug Combinations

General Information of This Drug (ID: DM9ZOMD)

Drug Name
CUDC-101   DM9ZOMD
Synonyms
CUDC-101; 1012054-59-9; CUDC 101; CUDC101; 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide; UNII-1A7Y9MP123; CHEMBL598797; 1A7Y9MP123; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide; AK174946; 7-((4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; 7-({4-[(3-ethynylphenyl)amino]-7-methoxyquinazolin-6-yl}oxy)-N-hydroxyheptanamide; 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; PubChem19149
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

26 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
BMS-754807 + CUDC-101 DC8T02F BMS-754807 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Carfilzomib + CUDC-101 DC1RT7D Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + Ruxolitinib DCSR29K Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
CUDC-101 + Ruxolitinib DCB96FK Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [2]
CUDC-101 + PD-0325901 DCXFTMV PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + PD-0325901 DCRCRD6 PD-0325901 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
CUDC-101 + Ym155 DC99F03 Ym155 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + THAPSIGARGIN DCENVKB THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + THAPSIGARGIN DCNE1B3 THAPSIGARGIN Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
CUDC-101 + Marizomib DCX77LV Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CUDC-101 + GDC-0980/RG7422 DCNDBWB GDC-0980/RG7422 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + Mitomycin DCLLSV2 Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
CUDC-101 + AS602868 DC3D2OI AS602868 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + Tamoxifen DC2ARVG Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + Idarubicin DCB28DP Idarubicin Glioblastoma? (Cell Line: T98G) [2]
CUDC-101 + Ciclopirox DC7U616 Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + IMD-0354 DC3JJ7K IMD-0354 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + BIIB-021 DCFCHTQ BIIB-021 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + PF-562271 DCE9EZD PF-562271 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
CUDC-101 + Ibrutinib DCPQDCM Ibrutinib Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Dorsomorphin + CUDC-101 DCY6SUZ Dorsomorphin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Dorsomorphin + CUDC-101 DCOAHLU Dorsomorphin Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PD-0325901 + CUDC-101 DCO2LUW PD-0325901 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
RTB101 + CUDC-101 DCP87VX RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
RTB101 + CUDC-101 DC1DRHZ RTB101 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Trametinib + CUDC-101 DCHAQEW Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
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⏷ Show the Full List of 26 DrugCom(s)

References

1 A Phase I Study of CUDC-101, a Multitarget Inhibitor of HDACs, EGFR, and HER2, in Combination with Chemoradiation in Patients with Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2015 Apr 1;21(7):1566-73.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.