Details of the Drug Combinations

General Information of This Drug (ID: DMB19L8)

Drug Name
Trihexyphenidyl   DMB19L8
Synonyms
trihexyphenidyl; Benzhexol; Triphenidyl; Trihexyphenidyle; Parkinane retard; Benzhexolum; 144-11-6; Trihexyphenidylum; Sedrena (free base); Trihexifenidilo; Trihexyphenidyle [INN-French]; Trihexifenidilo [INN-Spanish]; Trihexyphenidylum [INN-Latin]; Artane; Trihexylphenizyl; Trihexylphenidyl; Trihexylphenidyle; Trihexyphenidyl [INN:BAN]; Trihexylphenedyl; HSDB 3196; EINECS 205-614-4; NSC 12268; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-; 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol; BRN 0088959; Benzhexol; Trihexane; Trihexy; Artane Sequels; PMS Trihexyphenidyl; Apo-Trihex; Artane (TN); Trihexyphenidyl (INN); Apo-Trihex (TN); Apo-trihex (TN); SWR-0342SA
Indication
Disease Entry ICD 11 Status REF
Dystonia 8A02 Approved [1]
Parkinson disease 8A00.0 Approved [1]
Parkinsonian disorder N.A. Approved [2]
Postencephalitic Parkinson disease N.A. Approved [2]
Obesity 5B81 Investigative [3]
Therapeutic Class
Antiparkinson Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

90 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Chlorzoxazone + Trihexyphenidyl DCSI01N Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Levamisole + Trihexyphenidyl DCHQPIL Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Miconazole + Trihexyphenidyl DCU37NH Miconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Ribavirin-TP DCT6ATD Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Sertraline DC10TN1 Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Mebutamate DCD6AJO Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Baclofen DCGMF2F Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Aliskiren DCXHFT8 Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Dantrolene DCVGBGL Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Diethylcarbamazine DC8FFI0 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Lumefantrine DCOM53W Lumefantrine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Kanamycin DCCICD6 Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Triamterene DCU7514 Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Crotamiton DCB9EA1 Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Dactinomycin DCEP8AN Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Tindamax DCM5YY5 Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Furazolidone DCM6GQ6 Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Chlorphenesin DC4C1ER Chlorphenesin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + PMID28460551-Compound-2 DC4SAE6 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Methotrexate DCQ4WRT Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Vinblastine DCVSJ8Y Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Mephenytoin DCT0NJK Mephenytoin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Ezetimibe DCAZJA9 Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Dronedarone DC9D5SW Dronedarone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Rifampin DCF692M Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + IT-141 DCU7BFZ IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + BHV-0223 DCOTMHC BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Metyrosine DC0FJCA Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Efavirenz DCOX1YK Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Terameprocol DC0WWKQ Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Flavonoid derivative 1 DCFBEO2 Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Emetine DCSWEM2 Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Ursodeoxycholic acid DC1UZMZ Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Metformin DC0LSD7 Metformin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Phenprocoumon DC8S19P Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Cilastatin DC8ZRBJ Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + LY03004 DCBPMHB LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Aminosalicylic acid DCGQVZA Aminosalicylic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Pazopanib DCTF764 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Daidzin DCVSIY7 Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Fibrates DCFPZ84 Fibrates Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Armodafinil DCO3YC3 Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Ciprofibrate DCRD5FD Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Mecamylamine DCA3H0X Mecamylamine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Diphenidol DC9ZEI2 Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Tolazoline DCFDRAW Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Bosentan DCB3GPZ Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Sulfapyridine DCXHLHY Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + BIO-300 DCM6ZLU BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Niclosamide DCRREWQ Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Trazodone DC7B9QS Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Etonogestrel DCZ6RG4 Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Trifluoperazine DCQP8D5 Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Oseltamivir DCTIQYI Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + GINKGOLIDE A DCUKMZM GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Fenoprofen DC5W56J Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + BRL-15572 DC4CFW6 BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Imatinib DCUTLVN Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Bortezomib DCOW4WO Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Methylene blue DCAWKLZ Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Mebendazole DCK30NH Mebendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Ethinyl estradiol DCIA5FG Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Mesalazine DCZ3Q2K Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Olanzapine DCN496W Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Enalaprilat DCD2HB7 Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Leflunomide DCIJIZV Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Theophylline DCGDANU Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Amiloride DC8ICTI Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Brincidofovir DCEZLP3 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Asenapine DC2188W Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Maraviroc DC4PQDC Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Chlormezanone DCLTSNN Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Pizotyline DCJ3BSR Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Fosfomycin DC0ET92 Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Lacosamide DC8FL4M Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Iloprost DC3F0AK Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Nabilone DCOF1K1 Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Olmesartan medoxomil DCNN3EH Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Rufinamide DCR83GC Rufinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + PMID28870136-Compound-43 DCWMUEA PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Estramustine DCMGKJE Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Cerivastatin DCPPW3O Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Hydroxychloroquine DCBCPTA Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Atovaquone DC3W1AZ Atovaquone Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + ML323 DCEY768 ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Albendazole DCO4NFE Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + GSK2194069 DCIWW9L GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Tacrolimus DC4SECJ Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Tetracycline DC17XBT Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Trihexyphenidyl + Etomidate DCAYM09 Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
------------------------------------------------------------------------------------
⏷ Show the Full List of 90 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7315).
2 Trihexyphenidyl FDA Label
3 Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.