Details of the Drug Combinations

General Information of This Drug (ID: DMBAWDG)

Drug Name
Thiolactomycin   DMBAWDG
Synonyms
Antibiotic 2-200; 82079-32-1; (R)-(+)-Thiolactomycin; (+)-Thiolactomycin; BRN 4423670; 4-HYDROXY-3,5-DIMETHYL-5-(2-METHYL-BUTA-1,3-DIENYL)-5H-THIOPHEN-2-ONE; 2(5H)-Thiophenone, 3,5-dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-, (R-(E))-; (R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone; TLM; 2(5H)-Thiophenone, 4-hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-, (S-(E))-; (2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dienyl]thiophen-3-one; (5R)-Thiolactomycin; 2vb8
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Investigative [1]
Urinary tract infection GC08 Investigative [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

31 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Dihydroergotamine + Thiolactomycin DCYVO5F Dihydroergotamine Hepatoblastoma (Cell Line: HB3) [3]
Ivermectin + Thiolactomycin DCNFEBC Ivermectin DD2 (Cell Line: DD2) [3]
JTC-801 + Thiolactomycin DCRAHAH JTC-801 DD2 (Cell Line: DD2) [3]
Miconazole + Thiolactomycin DCS62J0 Miconazole DD2 (Cell Line: DD2) [3]
Miconazole + Thiolactomycin DC1CO7J Miconazole Hepatoblastoma (Cell Line: HB3) [4]
MK-4815 + Thiolactomycin DCGMEL0 MK-4815 DD2 (Cell Line: DD2) [3]
Omacetaxine mepesuccinate + Thiolactomycin DCDN5OX Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [4]
Proguanil + Thiolactomycin DCB049H Proguanil DD2 (Cell Line: DD2) [3]
Ritonavir + Thiolactomycin DCTWCLT Ritonavir DD2 (Cell Line: DD2) [3]
Ritonavir + Thiolactomycin DCSYDMF Ritonavir Hepatoblastoma (Cell Line: HB3) [3]
Sarpogrelate + Thiolactomycin DCO72CW Sarpogrelate DD2 (Cell Line: DD2) [3]
SB 228357 + Thiolactomycin DCQZ8OU SB 228357 DD2 (Cell Line: DD2) [3]
SB 228357 + Thiolactomycin DCP5KZ6 SB 228357 Hepatoblastoma (Cell Line: HB3) [4]
Sorafenib + Thiolactomycin DC4D1D1 Sorafenib Hepatoblastoma (Cell Line: HB3) [3]
Thiolactomycin + Artemether DCB4P02 Artemether DD2 (Cell Line: DD2) [3]
Thiolactomycin + Diltiazem DCR535G Diltiazem DD2 (Cell Line: DD2) [3]
Thiolactomycin + NITD609 DCAV25K NITD609 DD2 (Cell Line: DD2) [3]
Thiolactomycin + MK-4815 DCU30NQ MK-4815 DD2 (Cell Line: DD2) [3]
Thiolactomycin + Pyronaridine DCO2XXP Pyronaridine DD2 (Cell Line: DD2) [3]
Thiolactomycin + Mefloquine DC4AC75 Mefloquine DD2 (Cell Line: DD2) [3]
Thiolactomycin + Atovaquone DCFAATL Atovaquone DD2 (Cell Line: DD2) [3]
Thiolactomycin + Lumefantrine DC3RA4Y Lumefantrine Hepatoblastoma (Cell Line: HB3) [4]
Thiolactomycin + Diltiazem DCQE7W0 Diltiazem Hepatoblastoma (Cell Line: HB3) [4]
Thiolactomycin + Epothilone B DCWMNUU Epothilone B Hepatoblastoma (Cell Line: HB3) [4]
Thiolactomycin + Miconazole DC6SGNP Miconazole Hepatoblastoma (Cell Line: HB3) [4]
Thiolactomycin + Omacetaxine mepesuccinate DCMR8M5 Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [4]
Thiolactomycin + NITD609 DCHSP0I NITD609 Hepatoblastoma (Cell Line: HB3) [4]
Thiolactomycin + Mefloquine DCKKKQ0 Mefloquine Hepatoblastoma (Cell Line: HB3) [4]
Vorinostat + Thiolactomycin DCUYNMH Vorinostat Hepatoblastoma (Cell Line: HB3) [3]
ZM-447439 + Thiolactomycin DCYY8PA ZM-447439 DD2 (Cell Line: DD2) [3]
ZM-447439 + Thiolactomycin DCY6LK5 ZM-447439 Hepatoblastoma (Cell Line: HB3) [4]
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⏷ Show the Full List of 31 DrugCom(s)

References

1 Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
2 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.