General Information of This Drug (ID: DMBI4JG)

Drug Name
Isosorbide Dinitrate   DMBI4JG
Synonyms
Angidil; Astridine; BiDil; Cardis; Carvanil; Carvasin; Cedocard; Claodical; Cornilat; Coronex; Corosorbide; Corovliss; Difutrat; Dignionitrat; Dilatrate; Diniket; Dinitroisosorbide; Dinitrosorbide; Disorlon; Emoper; EureCor; Flindix; Frandol; Harrical; ISD; ISDN; IsoBid; Isochron; Isodinit; Isoket; Isorbid; Isordil; Isostat; Isotrate; Korodil; Langoran; Laserdil; Lomilan; Maycor; Myorexon; Nitrosorbid; Nitrosorbide; Nitrosorbon; Nosim; Resoidan; Rigedal; Sorbangil; Sorbide; Sorbidilat; Sorbidinitrate; Sorbidnitrate; Sorbislo; Sorbitrate; Sorbonit; Sorquad; Sorquat; Tinidil; Titradose; Vascardin; Vasodilat; Vasorbate; Xanyl; Cedocard Retard; Dilatrate SR; Dinitrato de isosorbida; Iso Bid; Isomak R; Isordil Tembids; Isosorbide dinitrato; Isosorbide dinitrato [DCIT]; Isosorbidi dinitras; Isosorbidi nitras; Rifloc Retard; Sorbide nitrate; Sorbidi nitras; Cardio 10; Cardonit 40; IBD 20; Isoket Retard 120; Isoket Retard120; Isoket retard 40; TYB 3215; Cedocard (TN); D-Isosorbide dinitrate; Dilatrate-SR; Dinitrate d'isosorbide; Dinitrate, Isosorbide; Dinitrato de isosorbida [INN-Spanish]; Iso-Bid; Iso-Mack; Iso-Puren; Isoket Retard-120; Isordil (TN); Isosorbidi dinitras [INN-Latin]; SDM No. 40; SDM No. 50; SST-101; Sorate-10; Sorate-5; Sorbide, dinitrate; Sorbitrate (TN); D-Isosorbide dinitrate-Lactose mixture; Dianhydrosorbitol 2,5-dinitrate; Dilatrate-sr (TN); Dinitrate d'isosorbide [INN-French]; Isosorbide 2,5-dinitrate; Sorbide T.D.; Glucitol, 1,4:3; Isosorbide dinitrate (JP15/USP/INN); Isosorbide dinitrate [USAN:INN:BAN:JAN]; Isosorbide dinitrate mixture with not <60% lactose, mannose, starch or calcium hydrogen phosphate [UN2907] [Flammable solid]; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; D-Glucitol, 1,4:3,6-dianhydro-, 2,5-dinitrate; [(3S,3aS,6R,6aS)-3-nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate; 1,4:3, 6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydrosorbitol 2, 5-dinitrate; 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate; 1,4:3,6-dianhydro-2,5-di-O-nitro-D-glucitol
Indication
Disease Entry ICD 11 Status REF
Anal fissure DB50.0 Approved [1]
Angina pectoris BA40 Approved [1]
Chronic heart failure BD1Z Approved [2]
Therapeutic Class
Vasodilator Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

53 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Aciclovir + Isosorbide dinitrate DCGTSAB Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acitretin + Isosorbide dinitrate DCK8JRV Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bepridil + Isosorbide dinitrate DC69LEJ Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BIO-300 + Isosorbide dinitrate DCX49I2 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bortezomib + Isosorbide dinitrate DC1Y5Y7 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Brincidofovir + Isosorbide dinitrate DCKE0WJ Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Cerivastatin + Isosorbide dinitrate DCCRQAE Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Citalopram + Isosorbide dinitrate DC3E66H Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dexmedetomidine + Isosorbide dinitrate DC61778 Dexmedetomidine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Doxapram + Isosorbide dinitrate DCOZBC7 Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Endoxifen + Isosorbide dinitrate DCGGXLZ Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Epinephrine + Isosorbide dinitrate DCO1QDI Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fomepizole + Isosorbide dinitrate DCJXJXE Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hydralazine + Isosorbide dinitrate DCONH4P Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Hyodeoxycholic acid + Isosorbide dinitrate DC6VK0I Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Primidone DC5HPSP Primidone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Gefitinib DC6ILB9 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + PMID28460551-Compound-2 DCCDUHB PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Vinblastine DCMO2E8 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Carglumic acid DCVGSOY Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Chlorzoxazone DCI4Q5J Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Docetaxel DCTEBCA Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Fluspirilene DC36TNV Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Arfolitixorin DCI7UT4 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Idarubicin DCBDOGB Idarubicin Glioblastoma? (Cell Line: T98G) [3]
Isosorbide dinitrate + Imatinib DCWVORD Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Methylene blue DCQXT65 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Mesalazine DCUZXG5 Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Topotecan DCJWL8D Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Trimethobenzamide DC6ZLEO Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Brincidofovir DC6LYLS Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Desoxycorticosterone pivalate DCOQ5NA Desoxycorticosterone pivalate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Cisatracurium DCQKE96 Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Mefloquine DCC3Q0F Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Doxorubicin DCB453Z Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Vorinostat DCC2RPK Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Cerivastatin DC0QBT5 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Isosorbide dinitrate + Cytarabine DCESTOH Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
IT-141 + Isosorbide dinitrate DCMLK16 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Itraconazole + Isosorbide dinitrate DCUHLZH Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Leflunomide + Isosorbide dinitrate DCJ9XUU Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maprotiline + Isosorbide dinitrate DCEHBCM Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Methotrexate + Isosorbide dinitrate DCMOIPZ Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Metyrosine + Isosorbide dinitrate DCD45RX Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mycophenolic acid + Isosorbide dinitrate DC0QXSZ Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pamidronate + Isosorbide dinitrate DC25RWD Pamidronate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
PF-02545920 + Isosorbide dinitrate DC9OWVN PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pyrazinamide + Isosorbide dinitrate DCEMW7B Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Repaglinide + Isosorbide dinitrate DCZ3YQL Repaglinide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ribavirin-TP + Isosorbide dinitrate DC8W5YX Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triapine + Isosorbide dinitrate DCE9Y13 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [4]
Triflupromazine + Isosorbide dinitrate DCE0UOA Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Zileuton + Isosorbide dinitrate DCD3WX3 Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 53 DrugCom(s)
1 Approved Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Isosorbide dinitrate + MC-1101 DCR8S4P MC-1101 Heart failure [5]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7051).
2 Isosorbide dinitrate FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015