Details of the Drug Combinations

General Information of This Drug (ID: DMBL79I)

Drug Name

Proguanil DMBL79I

Synonyms

Bigumal; Chlorguanid; Chlorguanide; Chloriguane; Chloroguanide; Paludrin; Proguanile; Proguanilum; Proguanile [DCIT]; Diguanyl (hydrochloride); Drinupal (hydrochloride); Paludrine (TN); Paludrine (hydrochloride); Palusil (hydrochloride); Proguanil [INN:BAN]; Proguanilum [INN-Latin]; RP-3359; Tirian (hydrochloride); M-4888 (hydrochloride); SN-12837 (hydrochloride); N1-p-Chlorophenyl-N5-isopropylbiguanide; N-(4-Chlorophenyl)-N'-(1-methylethyl)imidodicarbonimidic diamide; N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide; N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide; (1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine; 1-(p-Chlorophenyl)-5-isopropylbiguanide; 1-Isopropyl-5-(4-chlorophenyl)biguanide

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Approved	[1]
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Therapeutic Class

Antimalarials

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

33 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Atovaquone + Proguanil	DC3AZ8F	Atovaquone	DD2 (Cell Line: DD2)	[2]
Berberine + Proguanil	DCDUYTG	Berberine	DD2 (Cell Line: DD2)	[2]
Berberine + Proguanil	DCV3LXT	Berberine	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Proguanil	DCRLPBR	Dihydroergotamine	Hepatoblastoma (Cell Line: HB3)	[2]
Gentian violet + Proguanil	DCIU2DZ	Gentian violet	Hepatoblastoma (Cell Line: HB3)	[3]
Proguanil + Otilonium bromide	DCMCVN5	Otilonium bromide	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Zonisamide	DC65AF2	Zonisamide	DD2 (Cell Line: DD2)	[2]
Proguanil + Clindamycin	DCA2T8C	Clindamycin	DD2 (Cell Line: DD2)	[2]
Proguanil + Clindamycin	DC2QJW9	Clindamycin	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + OZ277	DC5JNRC	OZ277	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Lumefantrine	DCJTE22	Lumefantrine	DD2 (Cell Line: DD2)	[2]
Proguanil + Lumefantrine	DC27E4Y	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Nisoldipine	DCTH8GH	Nisoldipine	DD2 (Cell Line: DD2)	[2]
Proguanil + Nisoldipine	DC30I48	Nisoldipine	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Verapamil	DCFVO5D	Verapamil	DD2 (Cell Line: DD2)	[2]
Proguanil + Gentian violet	DCEWLQ2	Gentian violet	DD2 (Cell Line: DD2)	[2]
Proguanil + Thiolactomycin	DCB049H	Thiolactomycin	DD2 (Cell Line: DD2)	[2]
Proguanil + Nicardipine	DCOPULB	Nicardipine	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Elesclomol	DCS4LSK	Elesclomol	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + SB 228357	DCOIDN5	SB 228357	DD2 (Cell Line: DD2)	[2]
Proguanil + SB 228357	DCMSJ0C	SB 228357	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Epothilone B	DC7JAQW	Epothilone B	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Clomiphene citrate	DC3XMY7	Clomiphene citrate	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Naltrexone	DCUD1L2	Naltrexone	DD2 (Cell Line: DD2)	[2]
Proguanil + Naltrexone	DCIZMO8	Naltrexone	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Piperaquine	DCBBIX5	Piperaquine	DD2 (Cell Line: DD2)	[2]
Proguanil + MK-4815	DC0016S	MK-4815	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + NVP-AUY922	DCOXPYX	NVP-AUY922	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Primaquine	DC5X97G	Primaquine	Hepatoblastoma (Cell Line: HB3)	[2]
Proguanil + Atovaquone	DCGGLYU	Atovaquone	DD2 (Cell Line: DD2)	[2]
Proguanil + Atovaquone	DC359JS	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[2]
SB 228357 + Proguanil	DC7IGTU	SB 228357	DD2 (Cell Line: DD2)	[2]
SB 228357 + Proguanil	DCIUDJ1	SB 228357	Hepatoblastoma (Cell Line: HB3)	[3]
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⏷ Show the Full List of 33 DrugCom(s)

References

1	Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.