Details of the Drug Combinations

General Information of This Drug (ID: DMBS632)

• Drug Name: Buspirone (DMBS632)
• Synonyms: Ansial; Ansiced; Anxiron; Axoren; Bespar; Buspirona; Buspironum; Buspisal; Ansial (TN); Ansiced (TN); Anxiron (TN); Axoren (TN); Bespar (TN); BuSpar (TN); Buspimen (TN); Buspinol (TN); Buspiron (TN); Buspirona [INN-Spanish]; Buspirone (INN); Buspirone [INN:BAN]; Buspirone-MDTS; Buspironum [INN-Latin]; Buspisal (TN); Gen-Buspirone; Narol (TN); Sorbon (TN); Spamilan (TN); Spitomin (TN); Gen-Buspirone (TN); MJ-9022-1; N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide; 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione; 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione; 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione; 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione

Indication

Anxiety disorder; ICD 11: 6B00-6B0Z; Status: Approved [1]

• Therapeutic Class: Antianxiety Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

53 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Abacavir + Buspirone	DCLB91U	Abacavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Artemisinin + Buspirone	DCL8GI4	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Asenapine + Buspirone	DCEIIZY	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
BIO-300 + Buspirone	DCR2ZIK	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Bortezomib + Buspirone	DCH055K	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Brincidofovir + Buspirone	DCWVJ9L	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Mebutamate	DC140CO	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Triiodothyronine	DC02MA5	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Diethylcarbamazine	DCKUIE7	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Triamterene	DC49OO4	Triamterene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Terazosin	DCGDT5U	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Methotrexate	DCBFSVS	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Sivelestat	DCCRCF5	Sivelestat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Everolimus	DCTVNME	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Pepstatin	DCMCWI4	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + IT-141	DCD8DV8	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Palonosetron	DC90U5Y	Palonosetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Naringenin	DCOME5K	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Sulfapyridine	DCVIAOW	Sulfapyridine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + PF-02545920	DCPDPZM	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Tiagabine	DCQH5TQ	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Diazoxide	DCCQRKJ	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Methylene blue	DC6A5RN	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Maprotiline	DCBPD5V	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Sorafenib	DCOHOA8	Sorafenib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Asenapine	DCFB7E1	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Mycophenolic acid	DCM0MIP	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Mefloquine	DCT77RM	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Auranofin	DCURMO6	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + Vorinostat	DCWIH7O	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Buspirone + AS-1949490	DCX5GO8	AS-1949490	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Diethylcarbamazine + Buspirone	DCJK459	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Docetaxel + Buspirone	DCLBOPK	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Doxorubicin + Buspirone	DC48HOS	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Fenoprofen + Buspirone	DCEXQZZ	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Flavonoid derivative 1 + Buspirone	DCQRFSK	Flavonoid derivative 1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Idarubicin + Buspirone	DCABQHO	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Imatinib + Buspirone	DCPDEH8	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Leflunomide + Buspirone	DCSYKFZ	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Lumefantrine + Buspirone	DC5SPHZ	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mebutamate + Buspirone	DC2WNKD	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Metyrosine + Buspirone	DC3JOGI	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mycophenolic acid + Buspirone	DCUAOYV	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Nitisinone + Buspirone	DCN4E6L	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Oxandrolone + Buspirone	DC5ZKMJ	Oxandrolone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pentamidine + Buspirone	DC0F1Q1	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Phensuximide + Buspirone	DCA7VO9	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pyrazinamide + Buspirone	DCXMBAX	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Tacrolimus + Buspirone	DC0PDRF	Tacrolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Topotecan + Buspirone	DC3FM9S	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triapine + Buspirone	DCH1W00	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Buspirone	DCZBZX0	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Zaleplon + Buspirone	DC9587B	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acetazolamide + Buspirone	DC4VF9L	Acetazolamide	Central Apnea	[4]
Testosterone + Buspirone	DCG1LI0	Testosterone	Hypoactive Sexual Desire Disorder	[5]
Buspirone + Meperidine	DC72YHX	Meperidine	Acute Ischemic Stroke	[6]
Paroxetine + Buspirone	DCC96C6	Paroxetine	Major Depression Disorder	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 36).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] ClinicalTrials.gov (NCT00746954) Buspirone as a Potential Treatment for Recurrent Central Apnea
• [5] ClinicalTrials.gov (NCT01743235) Lybridos in Pre- and Postmenopausal Women With Hypoactive Sexual Desire Disorder Due to Maladaptive Activation of Sexual Inhibitory Systems
• [6] ClinicalTrials.gov (NCT01833312) Cooling Plus Best Medical Treatment Versus Best Medical Treatment Alone for Acute Ischaemic Stroke
• [7] ClinicalTrials.gov (NCT02273154) RandomizedControlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder