Details of the Drug Combinations

General Information of This Drug (ID: DMC520D)

Drug Name
Cycloguanil   DMC520D
Synonyms
Cycloguanil; Cycloguanyl; Cycloguanilum; 516-21-2; Chlorcycloguanil; Chlorguanide triazine; UNII-26RM326WVN; BN2410; WR 5473; BN-24-10; CHEMBL747; BRN 0229760; 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine; 26RM326WVN; QMNFFXRFOJIOKZ-UHFFFAOYSA-N; 1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine; 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine; 1-p-Chlorophenyl-1,2-dihydro-2,2-dimethyl-4,6-diamino-s-triazine
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

32 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Chlorzoxazone + Cycloguanil DC63ZOQ Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Ribavirin-TP DCPIKKB Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Mebutamate DCSO2UD Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Baclofen DCAS6MP Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Primidone DCU3DLE Primidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Dantrolene DCZMLNZ Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Diethylcarbamazine DC0JHHP Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Dactinomycin DCH8GTW Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Vinblastine DCM7APB Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Metyrosine DCPXAD0 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Terameprocol DCUGQSN Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Cilastatin DC6RUA8 Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Diphenidol DCQ9F5V Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Bosentan DCPGAAL Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + BIO-300 DCJC4BX BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Niclosamide DCXAHKA Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Isoproterenol DC83MOF Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Tiagabine DC5DUUI Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Diazoxide DCD7SPH Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Fenoprofen DCYO5CP Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Imatinib DC1RPO1 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Methylene blue DCKYO08 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Oxyphenbutazone DCUQG2U Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Leflunomide DC4DI4G Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Brincidofovir DCXE57Z Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Quinine DCC9PRL Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Iloprost DCQL1PB Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Estramustine DCGI2NX Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + Cerivastatin DCJK9ZX Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cycloguanil + AS-1949490 DCOTM8H AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lithium Citrate + Cycloguanil DCDVLC9 Lithium Citrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + Cycloguanil DC5XKRQ Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 32 DrugCom(s)

References

1 Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.