Details of the Drug Combinations

General Information of This Drug (ID: DMC5Q8X)

Drug Name
Berberine   DMC5Q8X
Synonyms
berberine; 2086-83-1; Berberin; Umbellatine; UNII-0I8Y3P32UF; 0I8Y3P32UF; CHEBI:16118; EINECS 218-229-1; Berberal; BRN 3570374; ST055798; 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Berbamine sulphate acid; CHEMBL12089; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium; BERBINIUM, 7,8,13,13a-TETRAHYDRO-9,10-DIMETHOXY-2,3-(METHYLE
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

13 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Berberine + Clindamycin DCJ05KV Clindamycin DD2 (Cell Line: DD2) [1]
Berberine + Proguanil DCDUYTG Proguanil DD2 (Cell Line: DD2) [1]
Berberine + Naltrexone DCR154A Naltrexone DD2 (Cell Line: DD2) [1]
Berberine + Piperaquine DC7S6PH Piperaquine DD2 (Cell Line: DD2) [1]
Berberine + Pyronaridine DCYXMYG Pyronaridine DD2 (Cell Line: DD2) [1]
Berberine + Atovaquone DCO0NXC Atovaquone DD2 (Cell Line: DD2) [1]
Berberine + Clindamycin DCEIT2X Clindamycin Hepatoblastoma (Cell Line: HB3) [2]
Berberine + Lumefantrine DCVOQR2 Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
Berberine + Proguanil DCV3LXT Proguanil Hepatoblastoma (Cell Line: HB3) [2]
Berberine + Naltrexone DC51WQC Naltrexone Hepatoblastoma (Cell Line: HB3) [2]
Berberine + Atovaquone DCEL2D9 Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
Emetine + Berberine DCEC27D Emetine DD2 (Cell Line: DD2) [1]
Tranylcypromine + Berberine DCOVEHQ Tranylcypromine DD2 (Cell Line: DD2) [1]
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⏷ Show the Full List of 13 DrugCom(s)
3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Berberine + Carvedilol DCRIRHD Carvedilol Cirrhosis Due to Hepatitis B [3]
Berberine + Rabeprazole DCMO25P Rabeprazole Dyspepsia [4]
Berberine + Vonoprazan DCY9GMT Vonoprazan Helicobacter Pylori Infection [5]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 ClinicalTrials.gov (NCT04543643) Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis
4 ClinicalTrials.gov (NCT04697186) Helicobacter Pylori Eradication With Berberine Plus Amoxicillin Triple Therapy Versus Bismuth-containing Quadruple Therapy
5 ClinicalTrials.gov (NCT05014334) Study on The Efficacy and Safety of Berberine-containing Triple Therapy in Helicobacter Pylori First-Line Eradication