Details of the Drug Combinations

General Information of This Drug (ID: DMCMDVR)

Drug Name

Triptolide DMCMDVR

Synonyms

triptolide; 38748-32-2; Triptolid; PG490; UNII-19ALD1S53J; NSC 163062; CHEMBL463763; CHEBI:9747; 19ALD1S53J; C20H24O6; PG-490; CPD000466307; Triptolide, Tripterygium wilfordii; (-)-Triptolide; PG 490; Trisoxireno(4b,5:6,7:8a,9)phenanthro(1,2-c)furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-; SMR000466307; NSC163062; Triptolide, 1; Triptolide(PG490)/; AC1Q6AXN; BSPBio_001595; KBioGR_000315; KBioSS_000315

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Phase 3	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Doxorubicin + Triptolide	DCQZUZZ	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Everolimus + Triptolide	DCL1KKW	Everolimus	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Plinabulin + Triptolide	DCWCZTG	Plinabulin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Triptolide + Carfilzomib	DCIXBUT	Carfilzomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Triptolide + Mitomycin	DCLQ120	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[3]
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1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Triptolide + Osimertinib	DCU2QJA	Osimertinib	Advanced Lung Non-Small Cell Carcinoma	[4]
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References

1	ClinicalTrials.gov (NCT02115659) Triptolide-Containing Formulation as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD). U.S. National Institutes of Health.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4	ClinicalTrials.gov (NCT05166616) Minnelide and Osimertinib for the Treatment of Advanced EGFR Mutated Non-Small Cell Lung Cancer