Details of the Drug Combinations

General Information of This Drug (ID: DMD1B8Z)

Drug Name

Dobutamine DMD1B8Z

Synonyms

Dobutamina; Dobutaminum; Dobutamine Hcl; Dobutamine [USAN]; Dobutamine hydrobromide; LY 81929; Lilly 81929; DL-dobutamine; Dobutamina [INN-Spanish]; Dobutamine Hcl in Dextrose 5%; Dobutamine(usp); Dobutaminum [INN-Latin]; Rac-dobutamine; Racemic-Dobutamine; Dobutamine (USP/INN); Dobutamine [USAN:BAN:INN]; Dobutamine Tartrate (1:1), (S-(R*,R*))-Isomer; (+-)-4-(2-((3-(p-Hydroxyphenyl)-1-methylpropyl)amino)ethyl)pyrocatechol; 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine; 4-(2-{[3-(4-hydroxyphenyl)-1-methylpropyl]amino}ethyl)benzene-1,2-diol; 4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol; 4-[2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]benzene-1,2-diol

Indication

Disease Entry	ICD 11	Status	REF
Heart failure	BD10-BD13	Approved	[1]
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Therapeutic Class

Cardiotonic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amlodipine + Dobutamine	DC4R3BG	Amlodipine	Heart Failure With Preserved Ejection Fraction	[2]
Dobutamine + Norepinephrine	DC26UOZ	Norepinephrine	Optimal Tissue Perfusion	[3]
Dobutamine + Allopurinol	DC3BOJN	Allopurinol	Cardiovascular Diseases	[4]
Regadenoson + Dobutamine	DCD4AES	Regadenoson	Coronary Artery Disease	[5]
Epinephrine + Dobutamine	DC4YI3F	Epinephrine	Oral Cancer	[6]
Milrinone + Dobutamine	DC00C8V	Milrinone	Shock, Cardiogenic	[7]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 535).
2	ClinicalTrials.gov (NCT01354613) Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF)
3	ClinicalTrials.gov (NCT03288051) Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps
4	ClinicalTrials.gov (NCT00281255) Intravenous Allopurinol to Improve Heart Function in Individuals With Dilated Cardiomyopathy
5	ClinicalTrials.gov (NCT00763035) Comparison of Dobutamine and Regadenoson Stress Cardiac Magnetic Resonance (MR)
6	ClinicalTrials.gov (NCT01418118) Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery
7	ClinicalTrials.gov (NCT05267886) CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock