Details of the Drug Combinations

General Information of This Drug (ID: DMD4OK0)

Drug Name
K-134   DMD4OK0
Synonyms
SULBACTAM; 68373-14-8; sulbactam acid; Sulbactamum; Betamaze; Penicillanic Acid Sulfone; (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide; penicillanic acid 1,1-dioxide; UNII-S4TF6I2330; CP 45899; CHEMBL403; CHEBI:9321; S4TF6I2330; Sulbactam;Penicillanic acid sulfone; (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 4,4-dioxide; Sulbactam [INN:BAN]; CP-45,899; Sulbactamum [INN-Latin]; DSSTox_CID_3605; DSSTox_RID_77104
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

60 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Albendazole + K-134 DCFEV9R Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Allopurinol + K-134 DC9EFA6 Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amiloride + K-134 DCY4B92 Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amodiaquine + K-134 DCD4BPK Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + K-134 DCMGRSW Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Baclofen + K-134 DC93QVH Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + K-134 DCLMCKU Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + K-134 DC0GIJ5 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + K-134 DCH4FCI Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clascoterone + K-134 DC2OEJC Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Emetine + K-134 DCIE0RK Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + K-134 DCQTK91 Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Everolimus + K-134 DCFDVK9 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + K-134 DCW5ILO Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + K-134 DCAW5MC Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hydralazine + K-134 DCHQOZ7 Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + K-134 DCVNPC9 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Aprepitant DCTV8G1 Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Diethylcarbamazine DC28BZU Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Miglustat DC8CF53 Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Flavonoid derivative 1 DCY2OEN Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Memantine DC9V59H Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Docetaxel DC3MRAN Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Cilastatin DCQCKRU Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + JZL195 DCMZ0SU JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Pazopanib DCUX71P Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + PF-02545920 DCOVGLF PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Idarubicin DC1STNX Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Imatinib DCWFYED Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Bortezomib DCFJAYH Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Methylene blue DCUK7MS Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Dopamine DCU7KTV Dopamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Oxyphenbutazone DCI3GGG Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Leflunomide DCTWGBN Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Mycophenolic acid DCZ3ASX Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Cisatracurium DCHXD7G Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Mefloquine DCXANUR Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Doxorubicin DCLIND6 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Iloprost DC6IA9X Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Silver sulfadiazine DCKXI2R Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Testolactone DCAXIZ7 Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Sumatriptan DC9173E Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Auranofin DCVSGSP Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Vorinostat DC6HZYE Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Cerivastatin DC48USM Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + ML323 DCA8G0K ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Tetracycline DCUF24Y Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Loperamide + K-134 DCBEVRI Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + K-134 DCAI6FI Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mesalazine + K-134 DCQKPTB Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + K-134 DCAT5TX Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + K-134 DCS1CW0 Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Probenecid + K-134 DCJAANE Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + K-134 DCJ4SF5 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ribavirin-TP + K-134 DCRX5AL Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Rifampin + K-134 DCLDMQP Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfapyridine + K-134 DCHSKKU Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sulfinpyrazone + K-134 DCP4QK2 Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + K-134 DC9TFCJ Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triapine + K-134 DC9EO6I Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 60 DrugCom(s)

References

1 ClinicalTrials.gov (NCT00783081) Safety and Efficacy of K-134 for the Treatment of Intermittent Claudication. U.S. National Institutes of Health.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.