Details of the Drug Combinations

General Information of This Drug (ID: DMEKAYI)

Drug Name

Netupitant DMEKAYI

Synonyms

R-1124; NK1 antagonist (emesis), Roche; Ro-67-3189

Indication

Disease Entry	ICD 11	Status	REF
Chemotherapy-induced nausea	MD90	Phase 3	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Palonosetron + Netupitant	DCN6O9G	Palonosetron	Chemotherapy-induced nausea	[2]
Palonosetron + Netupitant	DCUR6PZ	Palonosetron	Nausea Post Chemotherapy	[3]
Palonosetron + Netupitant	DCSPE9V	Palonosetron	Chemotherapy-induced Nausea and Vomiting (CINV)	[4]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5742).
2	A phase III study evaluating the safety and efficacy of NEPA, a fixed-dose combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting over repeated cycles of chemotherapy. Ann Oncol. 2014 Jul;25(7):1333-9.
3	ClinicalTrials.gov (NCT04669132) Efficacy of Olanzapine, Netupitant and Palonosetron in Controlling Nausea and Vomiting Associated With Highly Emetogenic Chemotherapy in Patients With Breast Cancer
4	ClinicalTrials.gov (NCT03204279) PK/PD Study of Netupitant and Palonosetron in Pediatric Patients for Prevention of Chemotherapy-induced Nausea and Vomiting