General Information of This Drug (ID: DMF28YC)

Drug Name
Atorvastatin   DMF28YC
Synonyms
Atogal; Atorlip; Atorpic; Atorvastatina; Atorvastatine; Atorvastatinium; Atrovastin; Cardyl; Faboxim; Lipotropic; Lipovastatinklonal; Liprimar; Lowden; Sincol; Sortis; Sotis; Torvacard; Torvast; Totalip; Tozalip; Tulip; Vastina; Xanator; Xarator; Xavator; Zurinel; Atorvastatin (INN); Atorvastatin [INN:BAN]; Lipitor (TN); Lipitor(TM); Sortis (TN); (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid; (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid; (R-(R*,R*))-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1H-pyrrole-1-heptanoic acid; (betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoic acid; 7-[2-(4-FLUORO-PHENYL)-5-ISOPROPYL-3-PHENYL-4-PHENYLCARBAMOYL-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID
Indication
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [1]
Angina pectoris BA40 Approved [1]
Arteriosclerosis BD40 Approved [1]
Cardiovascular disease BA00-BE2Z Approved [2]
Coronary atherosclerosis N.A. Approved [1]
Hypercholesterolaemia 5C80.0 Approved [1]
Hyperlipidemia 5C80.Z Approved [3]
Hyperlipidemia, familial combined, LPL related N.A. Approved [1]
Hypertriglyceridemia 5C80.1 Approved [1]
Inflammation 1A00-CA43.1 Approved [1]
Non-insulin dependent diabetes 5A11 Approved [1]
Psoriasis EA90 Approved [1]
Type-1/2 diabetes 5A10-5A11 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
Stroke 8B20 Investigative [1]
Venous thromboembolism BD72 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticholesteremic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Discontinued Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Atorvastatin + Sitagliptin DCJVFYJ Sitagliptin Cardiovascular disease [5]
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58 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Atorvastatin + Phenytoin DC19NQO Phenytoin Epilepsy [6]
Atorvastatin + MBX-8025 DC3YA9Y MBX-8025 Hyperlipidemia [7]
Atorvastatin + Rosuvastatin DC4DJ66 Rosuvastatin Hypercholesterolemia [8]
Atorvastatin + SB-649868 DC6WQLH SB-649868 Sleep Disorders [9]
Atorvastatin + Levacecarnine HCL DC7VG6A Levacecarnine HCL Non-alcoholic Steatohepatitis [10]
Atorvastatin + Zoledronate DCBINCJ Zoledronate Kidney Cancer [11]
Atorvastatin + Fenofibrate DCC9O0C Fenofibrate Mixed Dyslipidemia [12]
Atorvastatin + Pitavastatin DCG1B0D Pitavastatin Hypercholesterolemia [8]
Atorvastatin + Anacetrapib DCGM4MO Anacetrapib Dyslipidemia [13]
Atorvastatin + Isavuconazole DCK4EO1 Isavuconazole Pharmacokinetics of Isavuconazole [14]
Atorvastatin + Rosuvastatin DCLHRM0 Rosuvastatin Type IIa and IIb Hypercholesterolaemia [15]
Atorvastatin + Fenofibrate DCLQLI4 Fenofibrate Diabetes Mellitus [16]
Atorvastatin + Tofacitinib DCPFZ2X Tofacitinib Rheumatoid Arthritis [17]
Atorvastatin + Aspirin DC6H6B8 Aspirin Hypertension [18]
Atorvastatin + Danazol DCVVTEI Danazol Immune Thrombocytopenia [19]
Atorvastatin + BMS-201038 DC1GW85 BMS-201038 Effect of Atorvastatin on the Pharmacokinetics of Lomitapide [20]
Atorvastatin + Telmisartan DC9KH1T Telmisartan Essential Hypertension [21]
Atorvastatin + Relugolix DCBMFOS Relugolix Prostate Cancer [22]
Atorvastatin + Gemcabene DCGXBJT Gemcabene Hypercholesteremia [23]
Atorvastatin + Misoprostol DCLR367 Misoprostol Abortion Early [24]
Atorvastatin + Metformin DCWW4CM Metformin Breast Cancer [25]
Atorvastatin + Telmisartan DCYM3GU Telmisartan Diseases of the Circulatory System [26]
Calcium Acetate + Atorvastatin DCMA6X7 Calcium Acetate Calcinosis [27]
Dexamethasone + Atorvastatin DCMIO5Q Dexamethasone Immune Reconstitution Inflammatory Syndrome [28]
Ezetimibe + Atorvastatin DC8HX53 Ezetimibe Hypercholesterolemia [29]
Ezetimibe + Atorvastatin DCXTST5 Ezetimibe Hypercholesterolaemia [30]
Ezetimibe + Atorvastatin DCD5329 Ezetimibe Pharmacokinetics [31]
Ibuprofen + Atorvastatin DC0U7CU Ibuprofen Osteoarthritis [32]
Imiglitazar + Atorvastatin DCWXBQI Imiglitazar T2DM [33]
Lamotrigine + Atorvastatin DC7P73C Lamotrigine Epilepsy [6]
MCI-186 + Atorvastatin DCNYNIH MCI-186 Stroke [34]
Pravastatin + Atorvastatin DC2YZPU Pravastatin Rheumatoid Arthritis [35]
Semaglutide + Atorvastatin DCTNXZH Semaglutide Diabetes [36]
Simvastatin + Atorvastatin DCFE6EK Simvastatin Hypercholesterolemia [37]
Simvastatin + Atorvastatin DCYILLX Simvastatin Diabetes Mellitus, Type 2 [38]
Simvastatin + Atorvastatin DCJPS75 Simvastatin Atherosclerosis [39]
Atorvastatin + Aspirin DCWEH63 Aspirin Acute Stroke [40]
Atorvastatin + Methylprednisolone DC2QMO2 Methylprednisolone Thyroid Associated Ophthalmopathy [41]
Atorvastatin + Colchicine DC5ROEX Colchicine Non ST Segment Elevation Acute Coronary Syndrome [42]
Atorvastatin + Fluoxetine DC8VBYF Fluoxetine Depressive Disorder [43]
Atorvastatin + Apabetalone DC9O47U Apabetalone Dyslipidemia [44]
Atorvastatin + Pentoxifylline DC9X00C Pentoxifylline Male Erectile Disorder [45]
Atorvastatin + Mesalazine DCG0980 Mesalazine Inflammatory Bowel Diseases [46]
Atorvastatin + Aspirin DCMIK6V Aspirin Human Immunodeficiency Virus [47]
Atorvastatin + Sodium bicarbonate DCWBNDP Sodium bicarbonate Autosomal Dominant Polycystic Kidney Disease [48]
Atorvastatin + Temozolomide DCYRO34 Temozolomide Glioblastoma Multiforme [49]
Bempedoic acid + Atorvastatin DCWNO57 Bempedoic acid Hyperlipidemia [50]
Methotrexate + Atorvastatin DC838W5 Methotrexate Acute Myelogenous Leukemia [51]
Obeticholic acid + Atorvastatin DC1ZVYZ Obeticholic acid Nonalcoholic Steatohepatitis [52]
Atorvastatin + Apabetalone DC6TP5I Apabetalone Diabetes Mellitus, Type 2 [53]
Atorvastatin + Evacetrapib DCZ5EEE Evacetrapib Hypercholesterolemia [54]
Atorvastatin + Aspirin DCZQG4U Aspirin Prostate Cancer [55]
Glimepiride + Atorvastatin DCNMR1W Glimepiride Type 2 Diabetes Mellitus [56]
Methotrexate + Atorvastatin DCA69PQ Methotrexate Acute Myeloid Leukemia [57]
Simvastatin + Atorvastatin DC6TWJR Simvastatin Hypercholesterolemia [58]
Atorvastatin + Raltegravir DCNKSDC Raltegravir Aging-related Inflammation in HIV-infected Patients [59]
Atorvastatin + Acetylcysteine DCT7W2J Acetylcysteine Coronary Artery Disease [60]
Brilinta + Atorvastatin DCWFSDG Brilinta Ischemia [61]
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⏷ Show the Full List of 58 DrugCom(s)

References

1 Atorvastatin FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 205945.
4 ClinicalTrials.gov (NCT04380402) Atorvastatin in COVID-19. U.S. National Institutes of Health.
5 Clinical pipeline report, company report or official report of Merck.
6 ClinicalTrials.gov (NCT00627575) AED/Statin Interaction Study
7 ClinicalTrials.gov (NCT00701883) Safety and Benefit of MBX-8025 With and Without Commonly Used Statins in Moderately Overweight Patients With High Cholesterol. U. S. National Institute of Health. 2008.
8 ClinicalTrials.gov (NCT01660191) A Study Comparing CoQ10 Levels While Taking 3 Different Statins. U.S. National Institutes of Health.
9 ClinicalTrials.gov (NCT01299597) A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers.
10 ClinicalTrials.gov (NCT01617772) Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis
11 ClinicalTrials.gov (NCT00490698) Zoledronate With Atorvastatin in Renal Cell Carcinoma
12 ClinicalTrials.gov (NCT00300469) Evaluate Safety and Efficacy of ABT-335 in Combination With Atorvastatin in Subjects With Multiple Abnormal Lipid Levels in the Blood
13 ClinicalTrials.gov (NCT00977288) A Study of Safety and Efficacy of MK0859 (Anacetrapib) in Japanese Patients With Dyslipidemia (0859-029)
14 ClinicalTrials.gov (NCT01635946) Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Atorvastatin
15 ClinicalTrials.gov (NCT00631189) Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients
16 ClinicalTrials.gov (NCT00491400) Effect of a Fibrate and a Statin on Endothelial Dysfunction
17 ClinicalTrials.gov (NCT01059864) Study Of The Effects Of Atorvastatin On Cholesterol Levels In Rheumatoid Arthritis Patients Taking CP-690,550
18 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
19 ClinicalTrials.gov (NCT03460808) The Combination of Atorvastatin, Acetylcysteine and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
20 ClinicalTrials.gov (NCT02080455) Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Lomitapide in Healthy Subjects.
21 ClinicalTrials.gov (NCT01842256) Study to Investigate the Effect of Telmisartan/S-amlodipine on the Pharmacokinetic Properties of Atorvastatin.
22 ClinicalTrials.gov (NCT02093390) A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects
23 ClinicalTrials.gov (NCT02587416) Effect of Gemcabene on the Pharmacokinetics of Atorvastatin in Healthy Volunteers
24 ClinicalTrials.gov (NCT05342974) Atorvastatin as a Potential Adjunct to Misoprostol for Termination of Pregnancy
25 ClinicalTrials.gov (NCT01980823) Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer
26 ClinicalTrials.gov (NCT02579356) To Evaluate the Drug-drug Interaction Between Telmisartan and Atorvastatin in Healthy Male Volunteers
27 ClinicalTrials.gov (NCT00211939) CARE-2 (Calcium Acetate [PhosLo]/Sevelamer[Renagel] Evaluation Study 2) for Heart Calcification in Dialysis Patients
28 ClinicalTrials.gov (NCT01442428) Paradoxical Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) Treatment Trial
29 ClinicalTrials.gov (NCT00276484) To Evaluate Ezetimibe Plus Atorvastatin Versus Atorvastatin in Patients With High Cholesterol Not Controlled on Atorvastatin 40 mg (0653-090)
30 Efficacy and safety of fenofibric acid in combination with atorvastatin and ezetimibe in patients with mixed dyslipidemia. Am Heart J. 2010 Oct;160(4):759-66.
31 ClinicalTrials.gov (NCT00681525) A Multiple-Dose Pharmacokinetic Interaction Study Between ABT-335, Atorvastatin and Ezetimibe
32 ClinicalTrials.gov (NCT00411190) Study To Determine The Effects Of Doses Of Relacatib On The Metabolism Of Acetaminophen, Ibuprofen And Atorvastatin
33 ClinicalTrials.gov (NCT05681273) Drug-Drug Interaction Study of Chiglitazar in Healthy Subjects.
34 ClinicalTrials.gov (NCT01518231) Autologous Hematopoietic Stem Cell Transplantation in Ischemic Stroke
35 ClinicalTrials.gov (NCT04608344) Study to Evaluate Organic Anion Transporting Polypeptide (OATP) Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy Participants
36 ClinicalTrials.gov (NCT02243098) Investigating the Influence of Semaglutide on the Pharmacokinetics of Single Doses of Atorvastatin and Digoxin in Healthy Subjects
37 ClinicalTrials.gov (NCT02518516) High Potency Statins and Acute Kidney Injury
38 ClinicalTrials.gov (NCT02518503) High Potency Statins and the Risk of Diabetes
39 ClinicalTrials.gov (NCT00166530) EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)
40 ClinicalTrials.gov (NCT04824911) Statin and Dual Antiplatelet Therapy to Prevent Early Neurological Deterioration in Branch Atheromatous Disease
41 ClinicalTrials.gov (NCT03110848) Effects of Atorvastatin in Graves' Orbitopathy (GO)
42 ClinicalTrials.gov (NCT05250596) COLchicine On-admission to Reduce Inflammation in Acute Coronary Syndrome (COLOR-ACS)
43 ClinicalTrials.gov (NCT05792540) Clinical Study to Evaluate the Possible Efficacy of Dapagliflozin and Atorvastatin in Patients With Major Depressive Disorders
44 ClinicalTrials.gov (NCT01863225) Characterization of Multi-dose RVX000222 in Combination With Statin Treatment in Dyslipidemia
45 ClinicalTrials.gov (NCT03830164) Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer
46 ClinicalTrials.gov (NCT05567068) Atorvastatin Efficacy and Safety in Patients With Ulcerative Colitis
47 ClinicalTrials.gov (NCT02081638) Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study
48 ClinicalTrials.gov (NCT05870007) Atorvastatin and Alkali Therapy in Patients With Autosomal Dominant Polycystic Kidney Disease
49 ClinicalTrials.gov (NCT02029573) Efficacy and Safety of Atorvastatin in Combination With Radiotherapy and Temozolomide in Glioblastoma
50 ClinicalTrials.gov (NCT02659397) A Study Of Pharmacokinetics, Pharmacodynamics And Safety Of Adding ETC-1002 To Atorvastatin 80 mg
51 ClinicalTrials.gov (NCT01491958) Safety & Efficacy of Atorvastatin for Prophylaxis of Acute Graft Versus Host Disease in Patients With Hematological Malignancies HLA- Donor Hematopoietic Stem Cell Transplantation
52 ClinicalTrials.gov (NCT02633956) Combination Obeticholic Acid (OCA) and Statins for Monitoring of Lipids (CONTROL)
53 ClinicalTrials.gov (NCT02586155) Effect of RVX000222 on Time to Major Adverse Cardiovascular Events in High-Risk T2DM Subjects With CAD
54 ClinicalTrials.gov (NCT02260648) A Study of Evacetrapib (LY2484595) in Combination With Atorvastatin in Japanese Participants With Primary Hypercholesterolemia
55 ClinicalTrials.gov (NCT03819101) Trial of Acetylsalicylic Acid and Atorvastatin in Patients With Castrate-resistant Prostate Cancer
56 ClinicalTrials.gov (NCT01477853) A Study of the Co-administration of Sitagliptin and Atorvastatin in Inadequately Controlled Type 2 Diabetes Mellitus (MK-0431E-211). U.S. National Institutes of Health.
57 ClinicalTrials.gov (NCT03066466) Randomized Study: Standard of Care With or Without Atorvastatin for Prevention of GVHD for Matched Unrelated Donor BMT
58 ClinicalTrials.gov (NCT00664469) INdians Followed for INtensive Lipid Lowering Treatment and Its safetY
59 ClinicalTrials.gov (NCT02577042) Study of the Effect of Atorvastatin for Reducing Aging-related Complication in HIV-infected Patients Older Than 45 Years Receiving a Protease Inhibitor-based Regimen Versus a Raltegravir-based Regimen
60 ClinicalTrials.gov (NCT06139952) Ameliorating Contrast Induced Nephropathy After Coronary Angiography
61 ClinicalTrials.gov (NCT02910778) The Effect of Ticagrelor With or Without Atorvastatin on Endothelial Function in Healthy Males