Details of the Drug Combination

General Information of Drug Combination (ID: DC8VBYF)

Drug Combination Name
Atorvastatin Fluoxetine
Indication
Disease Entry Status REF
Depressive Disorder Phase 2 [1]
Component Drugs Atorvastatin   DMF28YC Fluoxetine   DM3PD2C
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Atorvastatin
Disease Entry ICD 11 Status REF
Acute coronary syndrome BA41 Approved [2]
Angina pectoris BA40 Approved [2]
Arteriosclerosis BD40 Approved [2]
Cardiovascular disease BA00-BE2Z Approved [3]
Coronary atherosclerosis N.A. Approved [2]
Hypercholesterolaemia 5C80.0 Approved [2]
Hyperlipidemia 5C80.Z Approved [4]
Hyperlipidemia, familial combined, LPL related N.A. Approved [2]
Hypertriglyceridemia 5C80.1 Approved [2]
Inflammation 1A00-CA43.1 Approved [2]
Non-insulin dependent diabetes 5A11 Approved [2]
Psoriasis EA90 Approved [2]
Type-1/2 diabetes 5A10-5A11 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [5]
Stroke 8B20 Investigative [2]
Venous thromboembolism BD72 Investigative [2]
Atorvastatin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HMG-CoA reductase (HMGCR) TTPADOQ HMDH_HUMAN Inhibitor [12]
HUMAN MYD88NF-kappa-B proinflammatory pathway (MYD88-NFKB pathway) TTDJB68 N.A. Inhibitor [13]
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Atorvastatin Interacts with 7 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [14]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [15]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [16]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [17]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [18]
Monocarboxylate transporter 1 (SLC16A1) DT342ZG MOT1_HUMAN Substrate [19]
Monocarboxylate transporter 2 (SLC16A7) DTLT3UG MOT2_HUMAN Substrate [20]
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⏷ Show the Full List of 7 DTP(s)
Atorvastatin Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [21]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [22]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [23]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [24]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [25]
UDP-glucuronosyltransferase 1A3 (UGT1A3) DEF2WXN UD13_HUMAN Metabolism [26]
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⏷ Show the Full List of 6 DME(s)
Atorvastatin Interacts with 93 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases ADR [27]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Activity [28]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Decreases Expression [29]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [30]
Kinesin-like protein KIF6 (KIF6) OTDH3MR4 KIF6_HUMAN Increases Response To Substance [31]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Activity [32]
Serum paraoxonase/arylesterase 1 (PON1) OTD0Z2XO PON1_HUMAN Increases Expression [33]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Increases Expression [34]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [34]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [29]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Decreases Expression [29]
Angiopoietin-2 (ANGPT2) OTEQK65P ANGP2_HUMAN Increases Expression [9]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Decreases Expression [9]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Decreases Expression [9]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [9]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Increases Expression [9]
Catalase (CAT) OTHEBX9R CATA_HUMAN Increases Activity [35]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [36]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Expression [37]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Decreases Expression [37]
Hexokinase-4 (GCK) OTR3Q0NN HXK4_HUMAN Decreases Expression [37]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Increases Expression [38]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Increases Expression [38]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Activity [39]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [40]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [30]
Insulin (INS) OTZ85PDU INS_HUMAN Increases Expression [41]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [10]
Interleukin-2 receptor subunit alpha (IL2RA) OT0MWCHG IL2RA_HUMAN Affects Expression [38]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [42]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [43]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Affects Expression [38]
Osteocalcin (BGLAP) OTK1YLWQ OSTCN_HUMAN Increases Expression [42]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [44]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Affects Expression [45]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [40]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [46]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [47]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [48]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Increases Expression [10]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Increases Expression [49]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Decreases Localization [50]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Decreases Expression [51]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [52]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [47]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [52]
Integrin alpha-M (ITGAM) OTAG6HWU ITAM_HUMAN Decreases Expression [51]
Coagulation factor V (F5) OTDMZ3LT FA5_HUMAN Decreases Activity [39]
Bone morphogenetic protein 2 (BMP2) OT23T37S BMP2_HUMAN Increases Expression [42]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [47]
E-selectin (SELE) OT33RZWY LYAM2_HUMAN Increases Expression [10]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Decreases Expression [48]
Integrin alpha-X (ITGAX) OTOGIMHE ITAX_HUMAN Decreases Expression [51]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [38]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [52]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [52]
Interleukin-12 subunit alpha (IL12A) OTDQT8GI IL12A_HUMAN Decreases Expression [53]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [54]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [46]
Nicotinamide N-methyltransferase (NNMT) OTFM38GU NNMT_HUMAN Increases Expression [55]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Decreases Expression [38]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Decreases Expression [40]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [52]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [52]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [56]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [57]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Affects Localization [58]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [30]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [59]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Decreases Activity [52]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [50]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [45]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [40]
CD83 antigen (CD83) OT1V4WQF CD83_HUMAN Decreases Expression [38]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [60]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [52]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Decreases Expression [61]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Increases Localization [57]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Activity [55]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [59]
Serum paraoxonase/arylesterase 2 (PON2) OT55NCTD PON2_HUMAN Increases Expression [62]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Decreases Expression [41]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Decreases Expression [45]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [60]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Increases Phosphorylation [55]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Response To Substance [46]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [63]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases ADR [27]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Transport [64]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Increases Uptake [65]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Decreases Transport [66]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Increases Uptake [65]
Sister chromatid cohesion protein DCC1 (DSCC1) OTPUVLZT DCC1_HUMAN Affects Response To Substance [67]
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⏷ Show the Full List of 93 DOT(s)
Indication(s) of Fluoxetine
Disease Entry ICD 11 Status REF
Bipolar depression N.A. Approved [6]
Bulimia nervosa 6B81 Approved [6]
Depression 6A70-6A7Z Approved [7]
Intracerebral hemorrhage N.A. Approved [6]
Major depressive disorder 6A70.3 Approved [6]
Obsessive compulsive disorder 6B20 Approved [6]
Panic disorder 6B01 Approved [6]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [8]
Fluoxetine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Modulator [71]
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Fluoxetine Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [72]
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Fluoxetine Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [73]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [74]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [75]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [75]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [76]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [77]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [78]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [79]
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⏷ Show the Full List of 8 DME(s)
Fluoxetine Interacts with 99 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Sodium-dependent serotonin transporter (SLC6A4) OT6FGDLW SC6A4_HUMAN Decreases Response To Substance [80]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Activity [81]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [68]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Increases Expression [68]
Serine protease hepsin (HPN) OT7QNA61 HEPS_HUMAN Increases Expression [68]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Increases Expression [68]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [68]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Decreases Expression [68]
Lanosterol synthase (LSS) OT9W2SFH LSS_HUMAN Increases Expression [68]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Increases Expression [68]
AP-1 complex subunit sigma-1A (AP1S1) OTQ2H8DN AP1S1_HUMAN Decreases Expression [68]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Decreases Expression [68]
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Increases Expression [68]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Increases Expression [68]
Fibronectin type III domain-containing protein 4 (FNDC4) OTOQK0WK FNDC4_HUMAN Increases Expression [68]
Protein DEPP1 (DEPP1) OTB36PHJ DEPP1_HUMAN Increases Expression [68]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Increases Expression [82]
5-hydroxytryptamine receptor 2C (HTR2C) OT6H8DE0 5HT2C_HUMAN Affects Binding [83]
Protein EVI2A (EVI2A) OTR8RUXQ EVI2A_HUMAN Increases Expression [69]
Inactive phospholipase C-like protein 1 (PLCL1) OTJL2C79 PLCL1_HUMAN Increases Expression [69]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [69]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [69]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [69]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Activity [84]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [85]
Ras-related protein Rab-7L1 (RAB29) OTDZT6LP RAB7L_HUMAN Increases Expression [70]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [70]
Long-chain-fatty-acid--CoA ligase 4 (ACSL4) OTI71MUJ ACSL4_HUMAN Increases Expression [70]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Increases Expression [70]
Membrane protein BRI3 (BRI3) OT1RWIH7 BRI3_HUMAN Increases Expression [70]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [70]
Fatty acid CoA ligase Acsl3 (ACSL3) OT3MWER1 ACSL3_HUMAN Increases Expression [70]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Increases Expression [70]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [86]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Phosphorylation [86]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Expression [87]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Activity [88]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [70]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [86]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Expression [86]
Fatty acid-binding protein, heart (FABP3) OT562DA1 FABPH_HUMAN Increases Expression [70]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Increases Expression [70]
Sphingomyelin phosphodiesterase (SMPD1) OTZSMA54 ASM_HUMAN Decreases Activity [89]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Affects Expression [90]
Transcobalamin-2 (TCN2) OT41D0L3 TCO2_HUMAN Increases Expression [70]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [91]
Potassium voltage-gated channel subfamily A member 3 (KCNA3) OTXSP3AA KCNA3_HUMAN Decreases Activity [92]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [86]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Affects Expression [91]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [86]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [86]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Decreases Expression [93]
Squalene synthase (FDFT1) OTGDISIT FDFT_HUMAN Increases Expression [70]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [86]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Increases Expression [70]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [94]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Affects Expression [91]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [94]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Increases Expression [70]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Decreases Expression [91]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [85]
Mevalonate kinase (MVK) OTHJCUKT KIME_HUMAN Increases Expression [70]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [95]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Increases Expression [70]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Increases Expression [96]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Increases Expression [70]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Increases Expression [70]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) OTSMGKXQ EBP_HUMAN Increases Expression [70]
Mitochondrial fission regulator 1 (MTFR1) OTLB1VFT MTFR1_HUMAN Increases Expression [70]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Increases Expression [70]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) OTK3EJFD NSDHL_HUMAN Increases Expression [70]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Increases Expression [70]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [70]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Decreases Activity [97]
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) OT0S9MFX LONF1_HUMAN Increases Expression [70]
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) OT991XS0 PP4P1_HUMAN Increases Expression [70]
Osteopetrosis-associated transmembrane protein 1 (OSTM1) OTKNJDH7 OSTM1_HUMAN Increases Expression [70]
Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11) OTANT9E6 GLT11_HUMAN Increases Expression [70]
RCC1 and BTB domain-containing protein 1 (RCBTB1) OTAYELI8 RCBT1_HUMAN Increases Expression [70]
Folliculin (FLCN) OTVM78XM FLCN_HUMAN Increases Expression [70]
Folliculin-interacting protein 1 (FNIP1) OTB1CC41 FNIP1_HUMAN Increases Expression [70]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [70]
StAR-related lipid transfer protein 4 (STARD4) OTPQ0BFY STAR4_HUMAN Increases Expression [70]
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) OTALABSK S38A2_HUMAN Increases Expression [70]
Ethanolamine-phosphate cytidylyltransferase (PCYT2) OTT8TAEA PCY2_HUMAN Increases Expression [70]
Sialidase-1 (NEU1) OTH9BY8Y NEUR1_HUMAN Increases Expression [70]
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) OT0ETO72 DHB14_HUMAN Increases Expression [70]
Ethanolaminephosphotransferase 1 (SELENOI) OTX2A47A EPT1_HUMAN Increases Expression [70]
Pantothenate kinase 3 (PANK3) OT77CFJ6 PANK3_HUMAN Increases Expression [70]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) OTB1FZJU ACSA_HUMAN Increases Expression [70]
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) OTR4990X PLPL3_HUMAN Increases Expression [70]
Maspardin (SPG21) OTMKJSYS SPG21_HUMAN Increases Expression [70]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Increases Expression [70]
Potassium voltage-gated channel subfamily D member 3 (KCND3) OTRPIH7J KCND3_HUMAN Decreases Activity [98]
Ergosterol biosynthetic protein 28 homolog (ERG28) OT2KAOBA ERG28_HUMAN Increases Expression [70]
5-hydroxytryptamine receptor 1A (HTR1A) OT38K9MK 5HT1A_HUMAN Increases Response To Substance [99]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Response To Substance [100]
Tryptophan 5-hydroxylase 2 (TPH2) OTKL5S1B TPH2_HUMAN Affects Response To Substance [101]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Increases Response To Substance [102]
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