Details of the Drug Combinations

General Information of This Drug (ID: DMFQWNI)

Drug Name
VR-776   DMFQWNI
Synonyms Premature ejaculation therapy (inhaled, PowerHale), Vectura
Indication
Disease Entry ICD 11 Status REF
Premature ejaculation HA03.0Z Discontinued in Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

62 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Amodiaquine + VR-776 DC8XYX9 Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + VR-776 DC8D5ED Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Artemisinin + VR-776 DCA2JZ1 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + VR-776 DCKJB7P BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + VR-776 DCSKO89 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + VR-776 DCIJMZ6 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxorubicin + VR-776 DCDZ9V8 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + VR-776 DCAT8BC Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + VR-776 DCM4XNX Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Eptifibatide + VR-776 DCIFXMF Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + VR-776 DC6J8O4 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hyodeoxycholic acid + VR-776 DCITPZK Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
JZL195 + VR-776 DCHQ61J JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + VR-776 DCZ0BR3 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maraviroc + VR-776 DCENQ5M Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Meclofenamic acid + VR-776 DCTSVE6 Meclofenamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metaxalone + VR-776 DCIM3KL Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + VR-776 DCNDME4 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + VR-776 DC5G4VK Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
NITD609 + VR-776 DCH6L28 NITD609 Hepatoblastoma (Cell Line: HB3) [3]
Pepstatin + VR-776 DCNCIGP Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + VR-776 DCJD0B6 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + VR-776 DCCMWB2 Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + VR-776 DC7JCY2 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Teriflunomide + VR-776 DCX2MIO Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + VR-776 DCI9VDL Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolazoline + VR-776 DC3KXBV Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Topotecan + VR-776 DCR7V6R Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Vinblastine + VR-776 DCR4WMV Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + VR-776 DC92EGU Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Ribavirin-TP DCCSX33 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Sertraline DC2C3GU Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Triiodothyronine DC3VWSL Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Lumefantrine DC2E2JK Lumefantrine DD2 (Cell Line: DD2) [2]
VR-776 + Triapine DC1X5Y5 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Emetine DCLTJMU Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Chlorzoxazone DC7JUDH Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Galantamine DC18EWA Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Pazopanib DCJB0ZS Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Daidzin DCNL4LC Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Zaleplon DCGJFJ2 Zaleplon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Diphenidol DCL0QF4 Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Sulfapyridine DCWCVP7 Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Trazodone DCT1OI7 Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Isoproterenol DC5LGD1 Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Oseltamivir DCZIT6V Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Fenoprofen DCYP5HZ Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Idarubicin DC06MY1 Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Imatinib DCOMCNM Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Mesalazine DCX9CQ6 Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Clascoterone DCBECY6 Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Trimethobenzamide DCFIHK8 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Maprotiline DC1IC2W Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Leflunomide DCHA9A2 Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Theophylline DCEW4F8 Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Acarbose DCUJ7XI Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Mycophenolic acid DCQO04P Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Hydralazine DCAGL6X Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Pyronaridine DCFYHFL Pyronaridine DD2 (Cell Line: DD2) [2]
VR-776 + Cytarabine DC1E0G9 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Ruxolitinib DCQ3XA7 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
WAY-100635 + VR-776 DCWBNBI WAY-100635 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 62 DrugCom(s)

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022099)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.