Details of the Drug Combinations

General Information of This Drug (ID: DMG58FX)

Drug Name
WAY-100635   DMG58FX
Synonyms
N-[2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide; 162760-96-5; Way 100635; UNII-71IH826FEG; CHEMBL31354; 71IH826FEG; N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylcyclohexanecarboxamide; WAY100635; Rec 0/0277; [3H]WAY100635; WAY 100,635; WAY-100,635; Lopac-W-108; AC1L1KWK; GTPL80; AC1Q5IB0; SCHEMBL84178; Lopac0_001229; WAY-100635 maleate salt/; GTPL3251; BDBM86708; DTXSID20167467; CHEBI:125619; EX-A1053; ZINC52541473; 2799AH; PDSP2_001699; PDSP1_001716; ABP000343; AKOS027313833; SB19513; NSC_104911; CS-0418; CCG-205303
Indication
Disease Entry ICD 11 Status REF
Eating disorder 6B82 Terminated [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

79 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + WAY-100635 DCIIN49 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + WAY-100635 DC5591P Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + WAY-100635 DCYIBBK BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bosentan + WAY-100635 DC4VTNF Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + WAY-100635 DCY05AN Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + WAY-100635 DC3UBZL Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cinacalcet + WAY-100635 DCQG7WE Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + WAY-100635 DCEQS77 Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Citalopram + WAY-100635 DC6TGK3 Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Colchicine + WAY-100635 DCXM98I Colchicine Lymphoid neoplasm (Cell Line: Mak) [2]
Cytarabine + WAY-100635 DCZXL7U Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dantrolene + WAY-100635 DCPJEQ1 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxorubicin + WAY-100635 DC84HE2 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Eptifibatide + WAY-100635 DC13XUG Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Gefitinib + WAY-100635 DCB4FFJ Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Iloprost + WAY-100635 DCWPJS5 Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
L-165041 + WAY-100635 DC4S7K5 L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + WAY-100635 DCY5VJS Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebutamate + WAY-100635 DCNMSNF Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + WAY-100635 DCX9LDU Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metaxalone + WAY-100635 DCPQJ49 Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nabilone + WAY-100635 DCTA9I1 Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + WAY-100635 DC2PAQE Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxyphenbutazone + WAY-100635 DC9D90Z Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pentamidine + WAY-100635 DCU1BZX Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + WAY-100635 DCYDEO9 PHA-739358 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Piperacetazine + WAY-100635 DCHV2GX Piperacetazine Hepatocellular carcinoma (Cell Line: Huh-7) [2]
Piperacetazine + WAY-100635 DCZLKZJ Piperacetazine Lymphoid neoplasm (Cell Line: Mak) [2]
Probenecid + WAY-100635 DC5AY8V Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + WAY-100635 DCTLHAN Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Sitagliptin + WAY-100635 DC54H71 Sitagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + WAY-100635 DC8AKX5 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolazoline + WAY-100635 DCXJTCC Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triflupromazine + WAY-100635 DCL6UAF Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + WAY-100635 DCSZY8L Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Aprepitant DC7RCAD Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Ribavirin-TP DCIEIAZ Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Pentostatin DCXG0QX Pentostatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Baclofen DC9N8SE Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Primidone DCGX0RA Primidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Diethylcarbamazine DCN7PO4 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Lumefantrine DCHBDFV Lumefantrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Imipramine DCXQQSZ Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Epinephrine DCB7NOS Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Miglustat DCBY9TU Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Vinblastine DC0QM15 Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Ramelteon DCGHWIF Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + 10-hydroxycamptothecin DC3J8S1 10-hydroxycamptothecin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + IT-141 DCKBZYY IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Methylergonovine DC1P2KG Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Palonosetron DC1XBY0 Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Metyrosine DCQXWOG Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Emetine DC5SILO Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Doxapram DCNBFZG Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Chlorzoxazone DC2UC1W Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Docetaxel DCD2CJU Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Phenprocoumon DCPSAY9 Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Marizomib DC54XLK Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
WAY-100635 + Galantamine DCG2Z4N Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Sulfinpyrazone DCQL3ZB Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + VR-776 DCWBNBI VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Sulfapyridine DCVFQO3 Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Niclosamide DCS8O14 Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Lubiprostone DCDQ0RM Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Isoproterenol DCZWTHU Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Fenoprofen DCJW3J6 Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Pargyline DCO67DG Pargyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Imatinib DC54DP6 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Darunavir DC5627T Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Maprotiline DCT5QUE Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Leflunomide DC168JB Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Brincidofovir DCFIZN5 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Mycophenolic acid DCCWMUN Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Pizotyline DC079OF Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Zileuton DC2WMB0 Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Cerivastatin DCV1LD7 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Busulfan DC1JVKW Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Enoxacin DC8ZXO7 Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
WAY-100635 + Ruxolitinib DCXDNJK Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 79 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 80).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.