Details of the Drug Combinations

General Information of This Drug (ID: DMGFPU2)

Drug Name

Linezolid DMGFPU2

Synonyms

Linezlid; ZLD; Zyvox; Zyvoxa; Zyvoxam; Zyvoxid; PNU 100766; U 100766; Linezolid & VRC3375; Linezolid [USAN:INN]; PNU-100766; U-100766; Zyvox (TN); Zyvoxam (TN); Zyvoxid (TN); NDA 21-130 Zyvox (linezolid tablets); NDA 21-131 Zyvox for injection (linezolid injection); NDA 21-132 Zyvox oral suspension (linzolid oral suspension); Linezolid (JAN/USAN/INN); PNU-100766, U-100766, Zyvoxid, Zyvoxam, Linezolid; N-((3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide; N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide; N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide; N-({5S)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide, N-[[(S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide; (S)-N-[[3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide; 111GE017

Indication

Disease Entry	ICD 11	Status	REF
Bacteremia	1A73	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Staphylococcal pneumonia	N.A.	Approved	[1]
Staphylococcus aureus infection	N.A.	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
Skin infection	1F28-1G0Z	Investigative	[1]
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Therapeutic Class

Antibiotics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

21 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Linezolid + Aztreonam	DC7155H	Aztreonam	Bacterial Infection	[4]
Linezolid + Moxifloxacin	DCKZGIW	Moxifloxacin	Skin Diseases, Infectious	[5]
Linezolid + Vancomycin	DCL6AED	Vancomycin	Complicated Skin and Structure Infection	[6]
Linezolid + Vancomycin	DCAX3EB	Vancomycin	Hip Prosthetic Joint Infection	[7]
Linezolid + Bedaquiline	DCDV0TP	Bedaquiline	Multi-drug Resistant Tuberculosis	[8]
Linezolid + Bedaquiline	DCLF1FC	Bedaquiline	Multi-drug Resistant Tuberculosis	[8]
Linezolid + Pyrazinamide	DCMOGRU	Pyrazinamide	Tuberculosis, Multidrug-Resistant	[9]
Linezolid + Bedaquiline	DCX979N	Bedaquiline	Tuberculosis, Multidrug-Resistant	[10]
Linezolid + Pyrazinamide	DCXMY9S	Pyrazinamide	Tuberculous Meningitis	[11]
Linezolid + Bedaquiline	DCYP39B	Bedaquiline	Tuberculosis, Multidrug-Resistant	[10]
Linezolid + Bedaquiline	DC7VMU1	Bedaquiline	Tuberculosis, Multidrug-Resistant	[10]
Linezolid + Bedaquiline	DCMV1JA	Bedaquiline	Multi-drug Resistant Tuberculosis	[8]
Linezolid + Cilastatin	DC5EN94	Cilastatin	Bacterial Pneumonia	[12]
Linezolid + Bedaquiline	DCCPSGD	Bedaquiline	Tuberculosis, Multidrug-Resistant	[13]
Linezolid + Pyrazinamide	DCG8UGE	Pyrazinamide	Tuberculosis Multi Drug Resistant Active	[14]
Linezolid + Bedaquiline	DCSYM2Q	Bedaquiline	Pulmonary Tuberculosis	[15]
Linezolid + Tazobactam	DCZ9CJN	Tazobactam	Bacterial Pneumonia	[12]
Linezolid + Cefiderocol	DC1IN8D	Cefiderocol	Healthcare-associated Pneumonia (HCAP)	[16]
Linezolid + Meropenem	DC1XM77	Meropenem	Healthcare-associated Pneumonia (HCAP)	[16]
Linezolid + Moxifloxacin	DCBUPAP	Moxifloxacin	Community Acquired Pneumonia	[17]
Linezolid + Daptomycin	DC6263U	Daptomycin	Health Care Associated Pneumonia	[18]
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References

1	Linezolid FDA Label
2	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 200222.
3	Therapeutic and Triage Strategies for 2019 Novel Coronavirus Disease in Fever Clinics. Lancet Respir Med. 2020 Mar;8(3):e11-e12.
4	ClinicalTrials.gov (NCT00633152) Efficacy and Safety of Ceftaroline Versus Linezolid in Subjects With Complicated Skin and Skin Structure Infections
5	ClinicalTrials.gov (NCT00865280) Study the Safety and Efficacy of PTK 0796 in Patients With Complicated Skin and Skin Structure Infection (CSSSI). U.S. National Institutes of Health.
6	ClinicalTrials.gov (NCT01363271) Cost Study of Linezolid Versus Vancomycin Among Previously Hospitalized Patients
7	ClinicalTrials.gov (NCT01757236) Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection
8	ClinicalTrials.gov (NCT04207112) Economic Evaluation of New MDR TB Regimens
9	ClinicalTrials.gov (NCT02619994) Treatment Shortening of MDR-TB Using Existing and New Drugs
10	ClinicalTrials.gov (NCT02589782) Pragmatic Clinical Trial for a More Effective Concise and Less Toxic MDR-TB Treatment Regimen(s)
11	ClinicalTrials.gov (NCT05383742) Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
12	ClinicalTrials.gov (NCT02493764) Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014)
13	ClinicalTrials.gov (NCT02754765) Evaluating Newly Approved Drugs for Multidrug-resistant TB
14	ClinicalTrials.gov (NCT02975570) Efficacy and Tolerability of Delamanid, Linezolid, Pyrazinamide and Levofloxacin
15	ClinicalTrials.gov (NCT02333799) A Phase 3 Study Assessing the Safety and Efficacy of Bedaquiline Plus PA-824 Plus Linezolid in Subjects With Drug Resistant Pulmonary Tuberculosis
16	ClinicalTrials.gov (NCT03032380) Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogens
17	ClinicalTrials.gov (NCT02559310) Study to Compare Lefamulin to Moxifloxacin (With or Without Linezolid) for the Treatment of Adults With Pneumonia
18	ClinicalTrials.gov (NCT01734694) Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patients