Details of the Drug Combinations

General Information of This Drug (ID: DMGFV3Z)

• Drug Name: Nizatidine (DMGFV3Z)
• Synonyms: Acinon; Antizid; Axid; Calmaxid; Cronizat; Distaxid; Galitidin; Gastrax; Naxidine; Niatidine; Nizatidina; Nizatidinum; Nizax; Nizaxid; Panaxid; Tazac; Ulcosol; Ulxid; Zanizal; Zinga; Axid Ar; Nizatidina [Spanish]; Nizatidinum [Latin]; Splendil ER; LY 139037; Acinon (TN); Axid (TN); LY-139037; Tazac (TN); ZE-101; ZL-101; Nizatidine (JAN/USP/INN); Nizatidine [USAN:BAN:INN:JAN]; N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine; N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamin; (E)-1-N'-[2-[[2-(dimethylaminomethyl)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine; (E)-N-[2-[[2-(dimethylaminomethyl)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-N'-methyl-2-nitroethene-1,1-diamine; (E)-N-{2-[({2-[(dimethylamino)methyl]-1,3-thiazol-4-yl}methyl)thio]ethyl}-N'-methyl-2-nitroethene-1,1-diamine

Indication

Acid-reflux disorder; ICD 11: DA22; Status: Approved [1]; Gastric ulcer; ICD 11: DA60; Status: Approved [2]; Peptic esophagitis; ICD 11: N.A.; Status: Approved [2]; Peptic ulcer; ICD 11: DA61; Status: Approved [2]

• Therapeutic Class: Antiulcer Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

50 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Nizatidine	DCVOBBB	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aciclovir + Nizatidine	DCBHW4Y	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bepridil + Nizatidine	DC7D3AQ	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Nizatidine	DCNY1A3	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Nizatidine	DCVZQKV	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorzoxazone + Nizatidine	DC70OG2	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Nizatidine	DCLYXY1	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Nizatidine	DCY1IYV	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Estramustine + Nizatidine	DCQPZO7	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Etomidate + Nizatidine	DC0TBIQ	Etomidate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Nizatidine	DC6GQV9	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
JZL195 + Nizatidine	DCGAHSM	JZL195	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Nizatidine	DC936QZ	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methylene blue + Nizatidine	DCU2E1G	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Nizatidine	DCGYYZ4	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Naringenin + Nizatidine	DCY0CMK	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Meclofenamic acid	DCBNT7A	Meclofenamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Triiodothyronine	DCOB1R7	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Diethylcarbamazine	DC3CCQT	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Fomepizole	DCVZPSN	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Ramelteon	DCVZLX5	Ramelteon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Everolimus	DC6TT6K	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Dronedarone	DCVM2O5	Dronedarone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Metyrosine	DCYCRX5	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Dichlorphenamide	DC72JHB	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Pentamidine	DCL5NL6	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Arfolitixorin	DCZ3C0K	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + BIO-300	DC65TTQ	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Lubiprostone	DC1JDIO	Lubiprostone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Allopurinol	DCVYFQY	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Imatinib	DCIXXFJ	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Bortezomib	DCPTV0L	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Topotecan	DC6B29U	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Dopamine	DC3G73E	Dopamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Maprotiline	DC1CS2P	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Quinine	DCOTFQX	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Mefloquine	DCLK2GV	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Doxorubicin	DCBVITL	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nizatidine + Metaxalone	DC7W6BH	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olmesartan medoxomil + Nizatidine	DCGYA4F	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PFK-158 + Nizatidine	DCTWZUZ	PFK-158	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Nizatidine	DCXGG3H	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Nizatidine	DC8748I	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Nizatidine	DCJOQ8H	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sulfinpyrazone + Nizatidine	DCL8XQL	Sulfinpyrazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tacrine + Nizatidine	DC10V1C	Tacrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Terameprocol + Nizatidine	DCGF1W9	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triapine + Nizatidine	DCU7TMP	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Valproic Acid + Nizatidine	DCEJCHF	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vinblastine + Nizatidine	DCK8IUV	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Lisinopril + Nizatidine	DCVMJ9I	Lisinopril	Gastroparesis	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7248).
• [2] Nizatidine FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT02232308) Modulation of Heme Oxygenase 1 by Nizatidine and Lisinopril in Healthy Subjects