General Information of This Drug (ID: DMGL19D)

Drug Name
Enzalutamide   DMGL19D
Synonyms MDV3100; Enzalutamide (AR inhibitor)
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

42 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
CORT-125134 + Enzalutamide DCQKVR2 CORT-125134 Prostate Cancer [2]
Crizotinib + Enzalutamide DCU75S9 Crizotinib Castration-resistant Prostate Cancer [3]
Docetaxel + Enzalutamide DCJ5U1O Docetaxel Metastatic Castration Resistant Prostate Cancer [4]
Enzalutamide + Anastrozole DCWQ4LW Anastrozole Breast Cancer [5]
Enzalutamide + Niclosamide DC3RWU5 Niclosamide Metastatic Prostate Carcinoma [6]
Enzalutamide + Tazemetostat DC4IVPN Tazemetostat Metastatic Prostate Cancer [7]
Enzalutamide + MK-4827 DC5F66S MK-4827 Metastatic Prostate Cancer [8]
Enzalutamide + GDC-0032 DCAIW4U GDC-0032 Estrogen Receptor Negative [9]
Enzalutamide + LEE011 DCHW86C LEE011 Castration-Resistant Prostate Carcinoma [10]
Enzalutamide + Niclosamide DCJ1HEN Niclosamide Castration Levels of Testosterone [11]
Enzalutamide + Indomethacin DCZ64FA Indomethacin Metastatic Prostate Carcinoma [12]
Enzalutamide + Mifepristone DCZUV4T Mifepristone Hormone-resistant Prostate Cancer [13]
Everolimus + Enzalutamide DCL9TE9 Everolimus Prostate Cancer [14]
Exemestane + Enzalutamide DC6X13Z Exemestane Breast Cancer [5]
Fulvestrant + Enzalutamide DCW7X3C Fulvestrant Breast Cancer [5]
Rifampicin + Enzalutamide DCIRHWQ Rifampicin Drug-Drug Interaction (DDI) [15]
Venetoclax + Enzalutamide DCS9N1Z Venetoclax Castration Levels of Testosterone [16]
ABIRATERONE + Enzalutamide DC4OUBQ ABIRATERONE Castration-Resistant Prostate Carcinoma [17]
ABIRATERONE + Enzalutamide DCH6TA6 ABIRATERONE Prostate Cancer Metastatic [18]
ABIRATERONE + Enzalutamide DCH6TE3 ABIRATERONE Prostatic Neoplasms, Castration-Resistant [19]
ABIRATERONE + Enzalutamide DCYXMPV ABIRATERONE Metastatic Castration-Resistant Prostatic Cancer [20]
AZD5363 + Enzalutamide DC50P11 AZD5363 Adenocarcinoma of the Prostate [21]
CORT-125134 + Enzalutamide DC9B3HT CORT-125134 Prostate Cancer [22]
Degarelix + Enzalutamide DC5WV96 Degarelix Prostate Cancer [23]
Degarelix + Enzalutamide DCY0KBT Degarelix Prostate Cancer [23]
Docetaxel + Enzalutamide DCMSCEH Docetaxel Metastatic Castration-Resistant Prostate Cancer (mCRPC) [24]
Enzalutamide + Tivozanib DC5MYIG Tivozanib Prostate Cancer [25]
Enzalutamide + Zoledronate DC756M4 Zoledronate Prostate Cancer [26]
Enzalutamide + LY2157299 DCCOML3 LY2157299 Prostate Cancer [27]
Enzalutamide + Metaiodobenzylguanidine I-131 DCE8HWE Metaiodobenzylguanidine I-131 Metastatic Prostate Cancer [28]
Fulvestrant + Enzalutamide DCG8LKC Fulvestrant Breast Cancer [29]
Goserelin + Enzalutamide DCXP3ZY Goserelin Prostate Cancer [30]
Leuprolide + Enzalutamide DCZAT12 Leuprolide Prostate Cancer [31]
Leuprolide + Enzalutamide DCNIJI0 Leuprolide Prostate Cancer [32]
Talazoparib + Enzalutamide DCS7RT7 Talazoparib Metastatic Prostate Cancer [33]
ABIRATERONE + Enzalutamide DCOODJK ABIRATERONE Metastatic Castration-resistant Prostate Cancer (mCRPC) [34]
Docetaxel + Enzalutamide DCFMABY Docetaxel Metastatic Castration Resistant Prostate Cancer [35]
Enzalutamide + Arn-509 DCGO6BD Arn-509 Prostate Cancer [36]
Gonadorelin + Enzalutamide DCXMZ7S Gonadorelin Prostatic Neoplasms [37]
Leuprolide + Enzalutamide DCPV5K3 Leuprolide Hormone Sensitive Prostate Cancer [38]
ABIRATERONE + Enzalutamide DC51IJ4 ABIRATERONE Prostate Cancer [39]
Enzalutamide + Flutamide DC9S8XC Flutamide Prostate Cancer [40]
------------------------------------------------------------------------------------
⏷ Show the Full List of 42 DrugCom(s)

References

1 Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
2 ClinicalTrials.gov (NCT03674814) Study of Drug 1 (Enzalutamide) Plus Drug 2 (Relacorilant) for Patients With Prostate Cancer
3 ClinicalTrials.gov (NCT02207504) Crizotinib in Combination With Enzalutamide in Metastatic Castration-resistant Prostate Cancer
4 ClinicalTrials.gov (NCT03328364) A Registry Based Study Evaluating Overall Survival and Treatment Length in mCRPC Patients Treated With Enzalutamide in Sweden
5 ClinicalTrials.gov (NCT01597193) Safety Study of Enzalutamide (MDV3100) in Patients With Incurable Breast Cancer
6 ClinicalTrials.gov (NCT03123978) Enzalutamide and Niclosamide in Treating Patients With Recurrent or Metastatic Castration-Resistant Prostate Cancer
7 ClinicalTrials.gov (NCT04179864) A Study of Tazemetostat With Enzalutamide or Abiraterone/Prednisone in Participants With Advanced Prostate Cancer
8 ClinicalTrials.gov (NCT02500901) Enzalutamide and Niraparib in the Treatment of Metastatic Castrate-Resistant Prostate Cancer (CRPC)
9 ClinicalTrials.gov (NCT02457910) Taselisib and Enzalutamide in Treating Patients With Androgen Receptor Positive Triple-Negative Metastatic Breast Cancer
10 ClinicalTrials.gov (NCT02555189) Enzalutamide With Ribociclib in Treating Patients With Metastatic Castrate-Resistant, Chemotherapy Naive Prostate Cancer That Retains Retinoblastoma Expression
11 ClinicalTrials.gov (NCT02532114) Niclosamide and Enzalutamide in Treating Patients With Castration-Resistant, Metastatic Prostate Cancer
12 ClinicalTrials.gov (NCT02935205) Enzalutamide and Indomethacin in Treating Patients With Recurrent or Metastatic Hormone-Resistant Prostate Cancer
13 ClinicalTrials.gov (NCT02012296) Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer
14 ClinicalTrials.gov (NCT02125084) Enzalutamide Plus Everolimus in Men With Metastatic Castrate-Resistant Prostate Cancer
15 ClinicalTrials.gov (NCT02138799) A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men
16 ClinicalTrials.gov (NCT03751436) Enzalutamide With Venetoclax in Treating Patients With Metastatic Castration Resistant Prostate Cancer
17 ClinicalTrials.gov (NCT03999515) Erdafitinib and Abiraterone Acetate or Enzalutamide in Treating Patients With Double Negative Prostate Cancer
18 ClinicalTrials.gov (NCT03295565) Optimal Sequencing of Treatment Options for Poor Risk mCRPC Previously Treated With Docetaxel
19 ClinicalTrials.gov (NCT05393791) Phase II Randomised Controlled Trial of Patient-specific Adaptive vs. Continuous Abiraterone or eNZalutamide in mCRPC
20 ClinicalTrials.gov (NCT02254785) Cabazitaxel vs Abiraterone or Enzalutamide in Patients With Poor Prognosis Metastatic Castration-resistant Prostate Cancer
21 ClinicalTrials.gov (NCT02525068) A Study of Enzalutamide in Combination With AZD5363 in Patients With mCRPC
22 ClinicalTrials.gov (NCT05726292) A Study of Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients With High-risk Localized Prostate Cancer
23 ClinicalTrials.gov (NCT01990196) Neoadjuvant Phase 2 Study Comparing the Effects of AR Inhibition With/Without SRC or MEK Inhibition in Prostate Cancer
24 ClinicalTrials.gov (NCT04015622) PROstate Cancer TReatment Optimization Via Analysis of Circulating Tumour DNA
25 ClinicalTrials.gov (NCT01885949) Tivozanib + Enzalutamide in Adv Prostate Cancer
26 ClinicalTrials.gov (NCT03336983) Luteinizing Hormone-releasing Hormone Analogue and Enzalutamide +/- Zoledronic Acid in Prostate Cancer Patients
27 ClinicalTrials.gov (NCT02452008) Study of TGF- Receptor Inhibitor Galunisertib (LY2157299) and Enzalutamide in Metastatic Castration-resistant Prostate Cancer
28 ClinicalTrials.gov (NCT03939689) Study of I-131-1095 Radiotherapy in Combination With Enzalutamide in Patients With Metastatic Castration-resistant Prostate Cancer Who Are Chemotherapy Naive and Have Progressed on Abiraterone
29 ClinicalTrials.gov (NCT02955394) Preoperative Fulvestrant With or Without Enzalutamide in ER+/Her2- Breast Cancer
30 ClinicalTrials.gov (NCT02430480) Using Multiparametric MRI to Evaluate Intraprostatic Tumor Responses and Androgen Resistance Patterns in Newly Diagnosed Prostate Cancer
31 ClinicalTrials.gov (NCT01547299) Study of Enzalutamide (Formerly MDV3100) as a Neoadjuvant Therapy for Patients Undergoing Prostatectomy for Localized Prostate Cancer
32 ClinicalTrials.gov (NCT02064582) Enzalutamide and Hormone Therapy Before, During, and After Radiation for High Risk Localized Prostate Cancer
33 ClinicalTrials.gov (NCT04332744) Enzalutamide Plus Talazoparib for the Treatment of Hormone Sensitive Prostate Cancer (ZZ-First)
34 ClinicalTrials.gov (NCT06136650) A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
35 ClinicalTrials.gov (NCT02288247) A Study to Assess the Benefit of Treatment Beyond Progression With Enzalutamide in Men Who Are Starting Treatment With Docetaxel After Worsening of Their Prostate Cancer When Taking Enzalutamide Alone
36 ClinicalTrials.gov (NCT04409288) Patient Preference of Apalutamide Versus Enzalutamide in Patients With Recurrent or Metastatic Hormone-Sensitive Prostate Cancer
37 ClinicalTrials.gov (NCT02446444) Enzalutamide in Androgen Deprivation Therapy With Radiation Therapy for High Risk, Clinically Localised, Prostate Cancer
38 ClinicalTrials.gov (NCT02319837) Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
39 ClinicalTrials.gov (NCT01995513) Safety Study of Continued Enzalutamide Treatment In Prostate Cancer Patients
40 ClinicalTrials.gov (NCT02918968) Study on Enzalutamide and Flutamide in Patients With Castration Resistant Prostate Cancer