Details of the Drug Combinations

General Information of This Drug (ID: DMGYWIK)

• Drug Name: RG6046 (DMGYWIK)

Indication

Breast cancer; ICD 11: 2C60-2C65; Status: Investigative [1]

List of Combinatorial Drugs (CBD) Containing This Drug

9 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Apilimod + RG6046	DC95734	Apilimod	Lymphoid neoplasm (Cell Line: Mak)	[2]
Clomiphene citrate + RG6046	DCHR3XK	Clomiphene citrate	Lymphoid neoplasm (Cell Line: Mak)	[2]
Colchicine + RG6046	DCHGP32	Colchicine	Lymphoid neoplasm (Cell Line: Mak)	[2]
Mizoribine + RG6046	DCS9IXJ	Mizoribine	Lymphoid neoplasm (Cell Line: Mak)	[2]
Omacetaxine mepesuccinate + RG6046	DCDWOWR	Omacetaxine mepesuccinate	Lymphoid neoplasm (Cell Line: Mak)	[2]
Ospemifene + RG6046	DC5RZV3	Ospemifene	Lymphoid neoplasm (Cell Line: Mak)	[2]
RG6046 + DZNep	DC4IWM4	DZNep	Lymphoid neoplasm (Cell Line: Mak)	[2]
RG6046 + Apilimod	DC3NGLV	Apilimod	Lymphoid neoplasm (Cell Line: Mak)	[2]
Sunitinib malate + RG6046	DC1ZLN7	Sunitinib malate	Lymphoid neoplasm (Cell Line: Mak)	[2]

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Pravastatin + RG6046	DCB04DR	Pravastatin	Breast Cancer	[3]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] ClinicalTrials.gov (NCT02621957) Effect of GDC-0810 on the Pharmacokinetics of Pravastatin in Healthy Female Subjects of Non-Childbearing Potential