Details of the Drug Combination

General Information of Drug Combination (ID: DCHR3XK)

• Drug Combination Name: Clomiphene Citrate + RG6046
• Indication: Lymphoid neoplasm; Status: Investigative [1]
• Component Drugs:
  Clomiphene Citrate (DMS51VC): Small molecular drug
  RG6046 (DMGYWIK): N.A.
• High-throughput Screening Result:
  Testing Cell Line: Mak
  Zero Interaction Potency (ZIP) Score: 8.112
  Bliss Independence Score: 8.776
  Loewe Additivity Score: 4.909
  LHighest Single Agent (HSA) Score: 11.542

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Clomiphene Citrate

Disease Entry	ICD 11	Status	REF
Female infertility	GA31.Z	Approved	[2]

Clomiphene Citrate Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Modulator	[3]

Clomiphene Citrate Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[4]

Indication(s) of RG6046

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Investigative	[2]

RG6046 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Modulator	[2]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.